You are here: Home / Exposures / Rice, Winslow, Hunter, 1999 / Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses (model 2)

Model Mathematics

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Component: environment

Component: N0

N0 = 1.0 - (P0 + N1 + P1)

Component: N1

\frac{d}{d time} (N1) = koff P1 - (g N1 + kon Ca N1)

Component: P0

\frac{d}{d time} (P0) = kon Ca N0 + g P1 - (koff P0 + f P0)

Component: P1

\frac{d}{d time} (P1) = kon Ca N1 + f P0 - (koff P1 + g P1)

Component: constants

koff = \frac{kon}{Kapp} Kapp = 0.0174 + 0.173 F + 1.54 F^{2.0} + 0.282 F^{3.0}

Component: force

F = \frac{alpha (P1 + N1)}{Fmax} Fmax = \frac{f}{f + g}

Source: Derived from workspace Rice, Winslow, Hunter, 1999 at changeset 1403ca54f018.

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