You are here: Home / Exposures / Rice, Winslow, Hunter, 1999 / Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses (model 3)

Model Mathematics

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Component: environment

Component: T

T = 1.0 - TCa

Component: TCa

\frac{d}{d time} (TCa) = kon Ca T - (koff TCa)

Component: N0

N0 = 1.0 - (P0 + N1 + P1)

Component: N1

\frac{d}{d time} (N1) = k1_P1 - (g N1 + k1 N1)

Component: P0

\frac{d}{d time} (P0) = k1 N0 + g P1 - (k1_P0 + f P0)

Component: P1

\frac{d}{d time} (P1) = k1 N1 + f P0 - (k1_P1 + g P1)

Component: constants

k1 = k1_{(\frac{TCa}{K_1_2})}^{N} K_1_2 = \frac{1.0}{1.0 + \frac{K_Ca}{1.5 - (SL_norm 1.0)}} N = 7.0 + 3.0 SL_norm SL_norm = \frac{SL - 1.7}{2.3 - 1.7}

Component: force

F = \frac{alpha (P1 + N1)}{Fmax} Fmax = \frac{f}{f + g}

Source: Derived from workspace Rice, Winslow, Hunter, 1999 at changeset 1403ca54f018.

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License: This work is licensed under a Creative Commons Attribution 3.0 Unported License.

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