About this model

Original publication:
 Kernik et al. (2019): "A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.

Figure 09

Inward rectifier potassium current (IK1) model optimization

The slow delayed rectifier potassium current was modeled here. experimental iPSC-CM data collected from Ma et al. (2011) , Kurokawa Lab (Li et al. (2017)), and the Jalife Lab (Herron et al. (2016)) in order to optimize data specific model.

Channels.cellml is the main CellML file which shows the I-V curves for different channels fitted to different experimental data from multiple laboratories. Its associated SED-ML file contains all the simulation settings. All the CellML files and SED-ML files need to be download in a same folder, as well as python script ( which can reproduce the I-V curve for IK1. In the python script, required SED-ML file is loaded into the script and by running the code following figure is reproduced. is used to generate the simulation and reproduces the graph shown in Figure 9 in the original study. In order to reproduce Figure 9, once all the files are downloaded to the same folder, execute the following script from the command line (command prompt):

cd [PathToThisFile]


I-V curve with dataset-specific model fits. Different colour represent experimental iPSC-CM data from multiple laboratories