Model Mathematics

\frac{d}{d t} (PIP2) = \frac{(- CaPLCg) Vmax2 PIP2}{km2 + PIP2} - (\frac{CaPLCg_star Vmax6 PIP2}{km6 + PIP2}) \frac{d}{d t} (DAG) = \frac{CaPLCg Vmax2 PIP2}{km2 + PIP2} + \frac{CaPLCg_star Vmax6 PIP2}{km6 + PIP2} \frac{d}{d t} (IP3) = \frac{CaPLCg Vmax2 PIP2}{km2 + PIP2} + \frac{CaPLCg_star Vmax6 PIP2}{km6 + PIP2}

\frac{d}{d t} (PLCg) = (- Ca) PLCg kf1 + CaPLCg kb1 \frac{d}{d t} (CaPLCg) = (- ((- Ca) PLCg kf1 + CaPLCg kb1)) + kf3 CaPLCg_star - (\frac{Vmax4 EGF_EGFR CaPLCg}{km4 + CaPLCg}) \frac{d}{d t} (CaPLCg_star) = (- (kf3 CaPLCg_star - (\frac{Vmax4 EGF_EGFR CaPLCg}{km4 + CaPLCg}))) + Ca PLCg_star kf5 - (kb5 CaPLCg_star) \frac{d}{d t} (PLCg_star) = (- Ca) PLCg_star kf5 + kb5 CaPLCg_star \frac{d}{d t} (Ca) = (- Ca) PLCg kf1 + CaPLCg kb1 + kb5 CaPLCg_star - (Ca PLCg_star kf5)