Generated Code
The following is c_ida code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 35 entries in the algebraic variable array.
There are a total of 18 entries in each of the rate and state variable arrays.
There are a total of 37 entries in the constant variable array.
*/
/*
* CONSTANTS[0] is kappa_R_12 in component BG_parameters (fmol_per_sec).
* CONSTANTS[1] is kappa_R_34 in component BG_parameters (fmol_per_sec).
* CONSTANTS[2] is kappa_R_56 in component BG_parameters (fmol_per_sec).
* CONSTANTS[3] is kappa_R_78 in component BG_parameters (fmol_per_sec).
* CONSTANTS[4] is kappa_R_1a_cGMP in component BG_parameters (fmol_per_sec).
* CONSTANTS[5] is kappa_R_1b_cGMP in component BG_parameters (fmol_per_sec).
* CONSTANTS[6] is kappa_R_2a_cGMP in component BG_parameters (fmol_per_sec).
* CONSTANTS[7] is kappa_R_2b_cGMP in component BG_parameters (fmol_per_sec).
* CONSTANTS[8] is kappa_R_1_sGC in component BG_parameters (fmol_per_sec).
* CONSTANTS[9] is kappa_R_2_sGC in component BG_parameters (fmol_per_sec).
* CONSTANTS[10] is kappa_R_3_sGC in component BG_parameters (fmol_per_sec).
* CONSTANTS[11] is kappa_R_4_sGC in component BG_parameters (fmol_per_sec).
* CONSTANTS[12] is kappa_R_DNO_sGC in component BG_parameters (fmol_per_sec).
* CONSTANTS[13] is K_A in component BG_parameters (per_fmol).
* CONSTANTS[14] is K_M in component BG_parameters (per_fmol).
* CONSTANTS[15] is K_Mp in component BG_parameters (per_fmol).
* CONSTANTS[16] is K_AM in component BG_parameters (per_fmol).
* CONSTANTS[17] is K_AMp in component BG_parameters (per_fmol).
* CONSTANTS[18] is K_Pi in component BG_parameters (per_fmol).
* CONSTANTS[19] is K_Ca_i in component BG_parameters (per_fmol).
* CONSTANTS[20] is K_cGMP in component BG_parameters (per_fmol).
* CONSTANTS[21] is K_GTP in component BG_parameters (per_fmol).
* CONSTANTS[22] is K_E5c in component BG_parameters (per_fmol).
* CONSTANTS[23] is K_PDE in component BG_parameters (per_fmol).
* CONSTANTS[24] is K_GTP_E5c in component BG_parameters (per_fmol).
* CONSTANTS[25] is K_cGMP_PDE in component BG_parameters (per_fmol).
* CONSTANTS[26] is K_GMP in component BG_parameters (per_fmol).
* CONSTANTS[27] is K_Eb in component BG_parameters (per_fmol).
* CONSTANTS[28] is K_NO in component BG_parameters (per_fmol).
* CONSTANTS[29] is K_E6c in component BG_parameters (per_fmol).
* CONSTANTS[30] is K_NO_product in component BG_parameters (per_fmol).
* VOI is t in component environment (second).
* CONSTANTS[31] is vol_myo in component environment (pL).
* STATES[0] is q_A in component environment (fmol).
* STATES[1] is q_M in component environment (fmol).
* STATES[2] is q_Mp in component environment (fmol).
* STATES[3] is q_AM in component environment (fmol).
* STATES[4] is q_AMp in component environment (fmol).
* STATES[5] is q_Pi in component environment (fmol).
* STATES[6] is q_Ca_i in component environment (fmol).
* STATES[7] is q_cGMP in component environment (fmol).
* STATES[8] is q_GTP in component environment (fmol).
* STATES[9] is q_E5c in component environment (fmol).
* STATES[10] is q_PDE in component environment (fmol).
* STATES[11] is q_GTP_E5c in component environment (fmol).
* STATES[12] is q_cGMP_PDE in component environment (fmol).
* STATES[13] is q_GMP in component environment (fmol).
* STATES[14] is q_Eb in component environment (fmol).
* STATES[15] is q_NO in component environment (fmol).
* STATES[16] is q_E6c in component environment (fmol).
* STATES[17] is q_NO_product in component environment (fmol).
* ALGEBRAIC[9] is v_R_12 in component HaiMurphy (fmol_per_sec).
* ALGEBRAIC[10] is v_R_34 in component HaiMurphy (fmol_per_sec).
* ALGEBRAIC[11] is v_R_56 in component HaiMurphy (fmol_per_sec).
* ALGEBRAIC[12] is v_R_78 in component HaiMurphy (fmol_per_sec).
* CONSTANTS[32] is n_Cai_SM in component environment (dimensionless).
* ALGEBRAIC[20] is v_R_1a_cGMP in component cGMP (fmol_per_sec).
* ALGEBRAIC[21] is v_R_1b_cGMP in component cGMP (fmol_per_sec).
* ALGEBRAIC[22] is v_R_2a_cGMP in component cGMP (fmol_per_sec).
* ALGEBRAIC[23] is v_R_2b_cGMP in component cGMP (fmol_per_sec).
* ALGEBRAIC[30] is v_R_1_sGC in component sGC (fmol_per_sec).
* ALGEBRAIC[31] is v_R_2_sGC in component sGC (fmol_per_sec).
* ALGEBRAIC[32] is v_R_3_sGC in component sGC (fmol_per_sec).
* ALGEBRAIC[33] is v_R_4_sGC in component sGC (fmol_per_sec).
* ALGEBRAIC[34] is v_R_DNO_sGC in component sGC (fmol_per_sec).
* CONSTANTS[33] is v_NO_generation in component environment (fmol_per_sec).
* ALGEBRAIC[0] is stress in component environment (dimensionless).
* CONSTANTS[34] is R in component constants (J_per_K_per_mol).
* CONSTANTS[35] is T in component constants (kelvin).
* CONSTANTS[36] is F in component constants (C_per_mol).
* ALGEBRAIC[1] is mu_A in component HaiMurphy (J_per_mol).
* ALGEBRAIC[2] is mu_M in component HaiMurphy (J_per_mol).
* ALGEBRAIC[3] is mu_Mp in component HaiMurphy (J_per_mol).
* ALGEBRAIC[4] is mu_AM in component HaiMurphy (J_per_mol).
* ALGEBRAIC[5] is mu_AMp in component HaiMurphy (J_per_mol).
* ALGEBRAIC[6] is mu_Pi in component HaiMurphy (J_per_mol).
* ALGEBRAIC[7] is mu_Ca_i in component HaiMurphy (J_per_mol).
* ALGEBRAIC[8] is mu_cGMP in component HaiMurphy (J_per_mol).
* ALGEBRAIC[13] is mu_GTP in component cGMP (J_per_mol).
* ALGEBRAIC[14] is mu_E5c in component cGMP (J_per_mol).
* ALGEBRAIC[15] is mu_cGMP in component cGMP (J_per_mol).
* ALGEBRAIC[16] is mu_PDE in component cGMP (J_per_mol).
* ALGEBRAIC[17] is mu_GTP_E5c in component cGMP (J_per_mol).
* ALGEBRAIC[18] is mu_cGMP_PDE in component cGMP (J_per_mol).
* ALGEBRAIC[19] is mu_GMP in component cGMP (J_per_mol).
* ALGEBRAIC[24] is mu_Eb in component sGC (J_per_mol).
* ALGEBRAIC[25] is mu_NO in component sGC (J_per_mol).
* ALGEBRAIC[26] is mu_E6c in component sGC (J_per_mol).
* ALGEBRAIC[27] is mu_E5c in component sGC (J_per_mol).
* ALGEBRAIC[28] is mu_cGMP in component sGC (J_per_mol).
* ALGEBRAIC[29] is mu_NO_product in component sGC (J_per_mol).
* RATES[0] is d/dt q_A in component environment (fmol).
* RATES[1] is d/dt q_M in component environment (fmol).
* RATES[2] is d/dt q_Mp in component environment (fmol).
* RATES[3] is d/dt q_AM in component environment (fmol).
* RATES[4] is d/dt q_AMp in component environment (fmol).
* RATES[5] is d/dt q_Pi in component environment (fmol).
* RATES[6] is d/dt q_Ca_i in component environment (fmol).
* RATES[7] is d/dt q_cGMP in component environment (fmol).
* RATES[8] is d/dt q_GTP in component environment (fmol).
* RATES[9] is d/dt q_E5c in component environment (fmol).
* RATES[10] is d/dt q_PDE in component environment (fmol).
* RATES[11] is d/dt q_GTP_E5c in component environment (fmol).
* RATES[12] is d/dt q_cGMP_PDE in component environment (fmol).
* RATES[13] is d/dt q_GMP in component environment (fmol).
* RATES[14] is d/dt q_Eb in component environment (fmol).
* RATES[15] is d/dt q_NO in component environment (fmol).
* RATES[16] is d/dt q_E6c in component environment (fmol).
* RATES[17] is d/dt q_NO_product in component environment (fmol).
* There are a total of 0 condition variables.
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
CONSTANTS[0] = 0.0628586;
CONSTANTS[1] = 10.3507;
CONSTANTS[2] = 1.13145;
CONSTANTS[3] = 0.031236;
CONSTANTS[4] = 192.663;
CONSTANTS[5] = 0.00328297;
CONSTANTS[6] = 56591.2;
CONSTANTS[7] = 0.0110353;
CONSTANTS[8] = 3.61127e+06;
CONSTANTS[9] = 0.00328297;
CONSTANTS[10] = 4.92446;
CONSTANTS[11] = 0.0361127;
CONSTANTS[12] = 0.01;
CONSTANTS[13] = 1.65213;
CONSTANTS[14] = 15.6959;
CONSTANTS[15] = 0.105259;
CONSTANTS[16] = 1.44065;
CONSTANTS[17] = 0.00966114;
CONSTANTS[18] = 723.915;
CONSTANTS[19] = 1;
CONSTANTS[20] = 1;
CONSTANTS[21] = 17040;
CONSTANTS[22] = 0.304602;
CONSTANTS[23] = 17.6706;
CONSTANTS[24] = 5190.42;
CONSTANTS[25] = 35.3412;
CONSTANTS[26] = 0.0051282;
CONSTANTS[27] = 0.0276911;
CONSTANTS[28] = 1;
CONSTANTS[29] = 30.4602;
CONSTANTS[30] = 0.1;
CONSTANTS[31] = 1;
STATES[0] = 1e-6;
STATES[1] = 1e-6;
STATES[2] = 0;
STATES[3] = 0;
STATES[4] = 0;
STATES[5] = 15;
STATES[6] = 1e-3;
STATES[7] = 1e-6;
STATES[8] = 0.0005;
STATES[9] = 1e-16;
STATES[10] = 1e-10;
STATES[11] = 1e-16;
STATES[12] = 1e-16;
STATES[13] = 1e-16;
STATES[14] = 1e-6;
STATES[15] = 0.00836;
STATES[16] = 1e-16;
STATES[17] = 1e-16;
CONSTANTS[32] = 1.66;
CONSTANTS[33] = 0.000114;
CONSTANTS[34] = 8.31;
CONSTANTS[35] = 310;
CONSTANTS[36] = 96485;
RATES[0] = 0.1001;
RATES[1] = 0.1001;
RATES[2] = 0.1001;
RATES[3] = 0.1001;
RATES[4] = 0.1001;
RATES[5] = 0.1001;
RATES[6] = 0.1001;
RATES[7] = 0.1001;
RATES[8] = 0.1001;
RATES[9] = 0.1001;
RATES[10] = 0.1001;
RATES[11] = 0.1001;
RATES[12] = 0.1001;
RATES[13] = 0.1001;
RATES[14] = 0.1001;
RATES[15] = 0.1001;
RATES[16] = 0.1001;
RATES[17] = 0.1001;
}
void
computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES,
double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS)
{
resid[0] = RATES[0] - - ALGEBRAIC[10]+ALGEBRAIC[12];
resid[1] = RATES[1] - - ALGEBRAIC[9]+ALGEBRAIC[12];
resid[2] = RATES[2] - ALGEBRAIC[9] - ALGEBRAIC[10];
resid[3] = RATES[3] - ALGEBRAIC[11] - ALGEBRAIC[12];
resid[4] = RATES[4] - ALGEBRAIC[10] - ALGEBRAIC[11];
resid[5] = RATES[5] - - ALGEBRAIC[9]+ALGEBRAIC[11];
resid[6] = RATES[6] - CONSTANTS[32]*(- ALGEBRAIC[9] - ALGEBRAIC[11]);
resid[7] = RATES[7] - (((ALGEBRAIC[9]+ALGEBRAIC[11]+ALGEBRAIC[21]) - ALGEBRAIC[22]) - ALGEBRAIC[23]) - 2.00000*ALGEBRAIC[33];
resid[8] = RATES[8] - - ALGEBRAIC[20];
resid[9] = RATES[9] - (- ALGEBRAIC[20]+ALGEBRAIC[21]+ALGEBRAIC[31]+ALGEBRAIC[32]) - ALGEBRAIC[33];
resid[10] = RATES[10] - - ALGEBRAIC[22]+ALGEBRAIC[23];
resid[11] = RATES[11] - ALGEBRAIC[20] - ALGEBRAIC[21];
resid[12] = RATES[12] - ALGEBRAIC[22] - ALGEBRAIC[23];
resid[13] = RATES[13] - ALGEBRAIC[23];
resid[14] = RATES[14] - - ALGEBRAIC[30]+ALGEBRAIC[33];
resid[15] = RATES[15] - ((- ALGEBRAIC[30]+ALGEBRAIC[33]) - ALGEBRAIC[34])+CONSTANTS[33];
resid[16] = RATES[16] - (ALGEBRAIC[30] - ALGEBRAIC[31]) - ALGEBRAIC[32];
resid[17] = RATES[17] - ALGEBRAIC[34];
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[0] = (STATES[3]+STATES[4])/1.00000;
}
void
computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[2] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[14]*STATES[1]);
ALGEBRAIC[3] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[15]*STATES[2]);
ALGEBRAIC[6] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[18]*STATES[5]);
ALGEBRAIC[7] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[19]*STATES[6]);
ALGEBRAIC[8] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[20]*STATES[7]);
ALGEBRAIC[9] = CONSTANTS[0]*(exp((ALGEBRAIC[2]+ALGEBRAIC[6]+ CONSTANTS[32]*ALGEBRAIC[7])/( CONSTANTS[34]*CONSTANTS[35])) - exp((ALGEBRAIC[3]+ALGEBRAIC[8])/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[1] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[13]*STATES[0]);
ALGEBRAIC[5] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[17]*STATES[4]);
ALGEBRAIC[10] = CONSTANTS[1]*(exp((ALGEBRAIC[1]+ALGEBRAIC[3])/( CONSTANTS[34]*CONSTANTS[35])) - exp(ALGEBRAIC[5]/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[4] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[16]*STATES[3]);
ALGEBRAIC[11] = CONSTANTS[2]*(exp((ALGEBRAIC[5]+ CONSTANTS[32]*ALGEBRAIC[7])/( CONSTANTS[34]*CONSTANTS[35])) - exp((ALGEBRAIC[4]+ALGEBRAIC[6]+ALGEBRAIC[8])/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[12] = CONSTANTS[3]*(exp(ALGEBRAIC[4]/( CONSTANTS[34]*CONSTANTS[35])) - exp((ALGEBRAIC[1]+ALGEBRAIC[2])/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[13] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[21]*STATES[8]);
ALGEBRAIC[14] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[22]*STATES[9]);
ALGEBRAIC[17] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[24]*STATES[11]);
ALGEBRAIC[20] = CONSTANTS[4]*(exp((ALGEBRAIC[13]+ALGEBRAIC[14])/( CONSTANTS[34]*CONSTANTS[35])) - exp(ALGEBRAIC[17]/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[15] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[20]*STATES[7]);
ALGEBRAIC[21] = CONSTANTS[5]*(exp(ALGEBRAIC[17]/( CONSTANTS[34]*CONSTANTS[35])) - exp((ALGEBRAIC[15]+ALGEBRAIC[14])/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[16] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[23]*STATES[10]);
ALGEBRAIC[18] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[25]*STATES[12]);
ALGEBRAIC[22] = CONSTANTS[6]*(exp((ALGEBRAIC[15]+ALGEBRAIC[16])/( CONSTANTS[34]*CONSTANTS[35])) - exp(ALGEBRAIC[18]/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[19] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[26]*STATES[13]);
ALGEBRAIC[23] = CONSTANTS[7]*(exp((ALGEBRAIC[18]+ALGEBRAIC[15])/( CONSTANTS[34]*CONSTANTS[35])) - exp((ALGEBRAIC[19]+ALGEBRAIC[16])/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[24] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[27]*STATES[14]);
ALGEBRAIC[25] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[28]*STATES[15]);
ALGEBRAIC[26] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[29]*STATES[16]);
ALGEBRAIC[30] = CONSTANTS[8]*(exp((ALGEBRAIC[24]+ALGEBRAIC[25])/( CONSTANTS[34]*CONSTANTS[35])) - exp(ALGEBRAIC[26]/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[27] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[22]*STATES[9]);
ALGEBRAIC[31] = CONSTANTS[9]*(exp(ALGEBRAIC[26]/( CONSTANTS[34]*CONSTANTS[35])) - exp(ALGEBRAIC[27]/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[32] = CONSTANTS[10]*(exp((ALGEBRAIC[26]+ALGEBRAIC[25])/( CONSTANTS[34]*CONSTANTS[35])) - exp((ALGEBRAIC[27]+ALGEBRAIC[25])/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[28] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[20]*STATES[7]);
ALGEBRAIC[33] = CONSTANTS[11]*(exp((ALGEBRAIC[27]+ ALGEBRAIC[28]*2.00000)/( CONSTANTS[34]*CONSTANTS[35])) - exp((ALGEBRAIC[24]+ALGEBRAIC[25])/( CONSTANTS[34]*CONSTANTS[35])));
ALGEBRAIC[29] = CONSTANTS[34]*CONSTANTS[35]*log( CONSTANTS[30]*STATES[17]);
ALGEBRAIC[34] = CONSTANTS[12]*(exp(ALGEBRAIC[25]/( CONSTANTS[34]*CONSTANTS[35])) - exp(ALGEBRAIC[29]/( CONSTANTS[34]*CONSTANTS[35])));
}
void
getStateInformation(double* SI)
{
SI[0] = 1.0;
SI[1] = 1.0;
SI[2] = 1.0;
SI[3] = 1.0;
SI[4] = 1.0;
SI[5] = 1.0;
SI[6] = 1.0;
SI[7] = 1.0;
SI[8] = 1.0;
SI[9] = 1.0;
SI[10] = 1.0;
SI[11] = 1.0;
SI[12] = 1.0;
SI[13] = 1.0;
SI[14] = 1.0;
SI[15] = 1.0;
SI[16] = 1.0;
SI[17] = 1.0;
}
void
computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES,
double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS)
{
}