Rendering of the source text

<?xml version="1.0"?>
<!--
This CellML file was generated on 10/10/2011 at 4:36:34 at PM using:

COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
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      <unit prefix="micro" units="mole"/>
   </units>
   <units name="micromolar">
      <unit units="micromole"/>
      <unit exponent="-1" units="litre"/>
   </units>
   <units name="per_micromolar">
      <unit exponent="-1" units="micromolar"/>
   </units>
   <units name="micromolar_per_second">
      <unit units="micromolar"/>
      <unit exponent="-1" units="second"/>
   </units>
   <units name="per_micromolar_per_second">
      <unit exponent="-1" units="micromolar"/>
      <unit exponent="-1" units="second"/>
   </units>
   <units name="per_second">
      <unit exponent="-1" units="second"/>
   </units>
   <component name="environment">
      <variable cmeta:id="environment_time" name="time" public_interface="out" units="second"/>
   </component>
   <component name="R_des">
      <variable cmeta:id="R_des_R_des" initial_value="0.1" name="R_des" public_interface="out" units="micromolar"/>
      <variable name="K_plus" public_interface="in" units="per_micromolar_per_second"/>
      <variable name="C_cyto" public_interface="in" units="micromolar"/>
      <variable name="n_i" public_interface="in" units="dimensionless"/>
      <variable name="K_act" public_interface="in" units="micromolar"/>
      <variable name="n_a" public_interface="in" units="dimensionless"/>
      <variable name="K_minus" public_interface="in" units="per_second"/>
      <variable name="time" public_interface="in" units="second"/>
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                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">1</cn>
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                              <power/>
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                                 <divide/>
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                                 <ci>K_act</ci>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
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               <apply>
                  <times/>
                  <ci>K_minus</ci>
                  <ci>R_des</ci>
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            </apply>
         </apply>
      </math>
   </component>
   <component name="C_cyto">
      <variable cmeta:id="C_cyto_C_cyto" initial_value="0.1" name="C_cyto" public_interface="out" units="micromolar"/>
      <variable name="K_1" public_interface="in" units="per_second"/>
      <variable name="b" public_interface="in" units="per_second"/>
      <variable name="n_i" public_interface="in" units="dimensionless"/>
      <variable name="I_ra" public_interface="in" units="micromolar"/>
      <variable name="Ca_tot" public_interface="in" units="micromolar"/>
      <variable name="alpha" public_interface="in" units="dimensionless"/>
      <variable name="V_MP" public_interface="in" units="micromolar_per_second"/>
      <variable name="n_p" public_interface="in" units="dimensionless"/>
      <variable name="K_p" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="second"/>
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                     <plus/>
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                        <times/>
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                        <times/>
                        <ci>I_ra</ci>
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                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>Ca_tot</ci>
                        <apply>
                           <times/>
                           <ci>C_cyto</ci>
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                              <plus/>
                              <ci>alpha</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           </apply>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
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                  <times/>
                  <ci>V_MP</ci>
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                     <times/>
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                        <divide/>
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                           <power/>
                           <ci>C_cyto</ci>
                           <ci>n_p</ci>
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                           <plus/>
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                              <power/>
                              <ci>K_p</ci>
                              <ci>n_p</ci>
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                           <apply>
                              <power/>
                              <ci>C_cyto</ci>
                              <ci>n_p</ci>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_micromolar">1</cn>
                  </apply>
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      <variable cmeta:id="I_ra_I_ra" name="I_ra" public_interface="out" units="micromolar"/>
      <variable name="I_rable" public_interface="in" units="micromolar"/>
      <variable name="K_act" public_interface="in" units="micromolar"/>
      <variable name="C_cyto" public_interface="in" units="micromolar"/>
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      <variable name="time" public_interface="in" units="second"/>
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                  <plus/>
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                     <power/>
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                        <divide/>
                        <ci>K_act</ci>
                        <ci>C_cyto</ci>
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                     <ci>n_a</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_rable">
      <variable cmeta:id="I_rable_I_rable" name="I_rable" public_interface="out" units="micromolar"/>
      <variable name="R_des" public_interface="in" units="micromolar"/>
      <variable name="IP3" public_interface="in" units="micromolar"/>
      <variable name="K_IP" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <eq/>
            <ci>I_rable</ci>
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               <divide/>
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                  <times/>
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                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">1</cn>
                     <ci>R_des</ci>
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                  <ci>IP3</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_IP</ci>
                  <ci>IP3</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="IP3">
      <variable cmeta:id="IP3_IP3" initial_value="0.1" name="IP3" public_interface="out" units="micromolar"/>
      <variable name="V_PLC" public_interface="in" units="micromolar"/>
      <variable name="V_3K" public_interface="in" units="micromolar"/>
      <variable name="V_5P" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
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               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>IP3</ci>
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            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <ci>V_PLC</ci>
                     <ci>V_3K</ci>
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                  <ci>V_5P</ci>
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               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component name="V_PLC">
      <variable cmeta:id="V_PLC_V_PLC" name="V_PLC" public_interface="out" units="micromolar"/>
      <variable name="V_plc" public_interface="in" units="micromolar_per_second"/>
      <variable name="gamma" public_interface="in" units="dimensionless"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_PLC</ci>
            <apply>
               <times/>
               <ci>gamma</ci>
               <ci>V_plc</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component name="V_3K">
      <variable cmeta:id="V_3K_V_3K" name="V_3K" public_interface="out" units="micromolar"/>
      <variable name="IP3" public_interface="in" units="micromolar"/>
      <variable name="V_k" public_interface="in" units="micromolar_per_second"/>
      <variable name="K_k" public_interface="in" units="micromolar"/>
      <variable name="C_cyto" public_interface="in" units="micromolar"/>
      <variable name="n_d" public_interface="in" units="dimensionless"/>
      <variable name="K_d" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
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                     <plus/>
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                     <ci>IP3</ci>
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                  <divide/>
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                     <power/>
                     <ci>C_cyto</ci>
                     <ci>n_d</ci>
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                  <apply>
                     <plus/>
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                        <power/>
                        <ci>K_d</ci>
                        <ci>n_d</ci>
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                        <power/>
                        <ci>C_cyto</ci>
                        <ci>n_d</ci>
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               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
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      </math>
   </component>
   <component name="V_5P">
      <variable cmeta:id="V_5P_V_5P" name="V_5P" public_interface="out" units="micromolar"/>
      <variable name="IP3" public_interface="in" units="micromolar"/>
      <variable name="IP4" public_interface="in" units="micromolar"/>
      <variable name="V_p1" public_interface="in" units="micromolar_per_second"/>
      <variable name="K_p1" public_interface="in" units="micromolar"/>
      <variable name="K_p2" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="second"/>
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                  <divide/>
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                     <plus/>
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                           <plus/>
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                           <apply>
                              <divide/>
                              <ci>IP4</ci>
                              <ci>K_p2</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>IP3</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="IP4">
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      <variable name="V_3K" public_interface="in" units="micromolar"/>
      <variable name="V_15P" public_interface="in" units="micromolar"/>
      <variable name="k" public_interface="in" units="per_second"/>
      <variable name="time" public_interface="in" units="second"/>
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         <apply>
            <eq/>
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                  <ci>time</ci>
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            <apply>
               <minus/>
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                  <times/>
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                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
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                  <ci>k</ci>
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   <component name="V_15P">
      <variable cmeta:id="V_15P_V_15P" name="V_15P" public_interface="out" units="micromolar"/>
      <variable name="IP3" public_interface="in" units="micromolar"/>
      <variable name="IP4" public_interface="in" units="micromolar"/>
      <variable name="V_p2" public_interface="in" units="micromolar_per_second"/>
      <variable name="K_p1" public_interface="in" units="micromolar"/>
      <variable name="K_p2" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <eq/>
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               <divide/>
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                  <times/>
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                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                  <ci>IP4</ci>
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               <apply>
                  <plus/>
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                     <times/>
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                        <plus/>
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                           <divide/>
                           <ci>IP3</ci>
                           <ci>K_p1</ci>
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                     </apply>
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                  <ci>IP4</ci>
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         </apply>
      </math>
   </component>
   <component name="model_parameters">
      <variable initial_value="1.3" name="V_plc" public_interface="out" units="micromolar_per_second"/>
      <variable initial_value="0.5" name="V_k" public_interface="out" units="micromolar_per_second"/>
      <variable initial_value="1" name="K_k" public_interface="out" units="micromolar"/>
      <variable initial_value="0.3" name="K_d" public_interface="out" units="micromolar"/>
      <variable initial_value="2" name="n_d" public_interface="out" units="dimensionless"/>
      <variable initial_value="5" name="V_p1" public_interface="out" units="micromolar_per_second"/>
      <variable initial_value="10" name="K_p1" public_interface="out" units="micromolar"/>
      <variable initial_value="0.2" name="V_p2" public_interface="out" units="micromolar_per_second"/>
      <variable initial_value="2" name="K_p2" public_interface="out" units="micromolar"/>
      <variable initial_value="0.01" name="k" public_interface="out" units="per_second"/>
      <variable initial_value="0.2" name="gamma" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.1" name="alpha" public_interface="out" units="dimensionless"/>
      <variable initial_value="80" name="Ca_tot" public_interface="out" units="micromolar"/>
      <variable initial_value="4" name="V_MP" public_interface="out" units="micromolar_per_second"/>
      <variable initial_value="0.35" name="K_p" public_interface="out" units="micromolar"/>
      <variable initial_value="2" name="n_p" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.56" name="K_act" public_interface="out" units="micromolar"/>
      <variable initial_value="0.15" name="K_inh" public_interface="out" units="micromolar"/>
      <variable initial_value="3" name="n_a" public_interface="out" units="dimensionless"/>
      <variable initial_value="4" name="n_i" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.5" name="K_minus" public_interface="out" units="per_second"/>
      <variable name="K_plus" public_interface="out" units="per_micromolar_per_second"/>
      <variable initial_value="7e-4" name="b" public_interface="out" units="per_second"/>
      <variable initial_value="2.57" name="K_1" public_interface="out" units="per_second"/>
      <variable initial_value="1" name="K_IP" public_interface="out" units="micromolar"/>
      <variable name="time" public_interface="in" units="second"/>
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               <divide/>
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                  <power/>
                  <ci>K_inh</ci>
                  <ci>n_i</ci>
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   <connection>
      <map_components component_1="environment" component_2="model_parameters"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="R_des"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="C_cyto"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="I_ra"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="I_rable"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="IP3"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="V_PLC"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="V_3K"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="V_5P"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="IP4"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="V_15P"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="R_des" component_2="model_parameters"/>
      <map_variables variable_1="K_plus" variable_2="K_plus"/>
      <map_variables variable_1="n_i" variable_2="n_i"/>
      <map_variables variable_1="K_act" variable_2="K_act"/>
      <map_variables variable_1="n_a" variable_2="n_a"/>
      <map_variables variable_1="K_minus" variable_2="K_minus"/>
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   <connection>
      <map_components component_1="C_cyto" component_2="model_parameters"/>
      <map_variables variable_1="K_1" variable_2="K_1"/>
      <map_variables variable_1="b" variable_2="b"/>
      <map_variables variable_1="Ca_tot" variable_2="Ca_tot"/>
      <map_variables variable_1="alpha" variable_2="alpha"/>
      <map_variables variable_1="V_MP" variable_2="V_MP"/>
      <map_variables variable_1="n_p" variable_2="n_p"/>
      <map_variables variable_1="K_p" variable_2="K_p"/>
      <map_variables variable_1="n_i" variable_2="n_i"/>
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   <connection>
      <map_components component_1="I_ra" component_2="model_parameters"/>
      <map_variables variable_1="n_a" variable_2="n_a"/>
      <map_variables variable_1="K_act" variable_2="K_act"/>
   </connection>
   <connection>
      <map_components component_1="I_rable" component_2="model_parameters"/>
      <map_variables variable_1="K_IP" variable_2="K_IP"/>
   </connection>
   <connection>
      <map_components component_1="V_PLC" component_2="model_parameters"/>
      <map_variables variable_1="gamma" variable_2="gamma"/>
      <map_variables variable_1="V_plc" variable_2="V_plc"/>
   </connection>
   <connection>
      <map_components component_1="V_3K" component_2="model_parameters"/>
      <map_variables variable_1="K_d" variable_2="K_d"/>
      <map_variables variable_1="K_k" variable_2="K_k"/>
      <map_variables variable_1="n_d" variable_2="n_d"/>
      <map_variables variable_1="V_k" variable_2="V_k"/>
   </connection>
   <connection>
      <map_components component_1="V_5P" component_2="model_parameters"/>
      <map_variables variable_1="V_p1" variable_2="V_p1"/>
      <map_variables variable_1="K_p1" variable_2="K_p1"/>
      <map_variables variable_1="K_p2" variable_2="K_p2"/>
   </connection>
   <connection>
      <map_components component_1="IP4" component_2="model_parameters"/>
      <map_variables variable_1="k" variable_2="k"/>
   </connection>
   <connection>
      <map_components component_1="V_15P" component_2="model_parameters"/>
      <map_variables variable_1="V_p2" variable_2="V_p2"/>
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   <connection>
      <map_components component_1="C_cyto" component_2="R_des"/>
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      <map_variables variable_1="I_ra" variable_2="I_ra"/>
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      <map_components component_1="C_cyto" component_2="V_3K"/>
      <map_variables variable_1="C_cyto" variable_2="C_cyto"/>
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   <connection>
      <map_components component_1="I_ra" component_2="I_rable"/>
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   <connection>
      <map_components component_1="IP3" component_2="I_rable"/>
      <map_variables variable_1="IP3" variable_2="IP3"/>
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   <connection>
      <map_components component_1="IP3" component_2="V_PLC"/>
      <map_variables variable_1="V_PLC" variable_2="V_PLC"/>
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   <connection>
      <map_components component_1="IP3" component_2="V_3K"/>
      <map_variables variable_1="IP3" variable_2="IP3"/>
      <map_variables variable_1="V_3K" variable_2="V_3K"/>
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   <connection>
      <map_components component_1="IP3" component_2="V_5P"/>
      <map_variables variable_1="IP3" variable_2="IP3"/>
      <map_variables variable_1="V_5P" variable_2="V_5P"/>
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   <connection>
      <map_components component_1="IP3" component_2="V_15P"/>
      <map_variables variable_1="IP3" variable_2="IP3"/>
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   <connection>
      <map_components component_1="IP4" component_2="V_5P"/>
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      <map_variables variable_1="V_15P" variable_2="V_15P"/>
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   <connection>
      <map_components component_1="IP4" component_2="V_3K"/>
      <map_variables variable_1="V_3K" variable_2="V_3K"/>
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          Simulations of the effects of inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities on Ca2+ oscillations
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