<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 10.02.2012 at 13:45:07 using:
COR (0.9.31.1409)
Copyright 2002-2012 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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<section id="sec_status">
<title>Model Status</title>
<para>
This version has been curated and unit-checked by Penny Noble and is known to run in COR and PCEnv. This variant is the STRETCH model, which includes acetylcholine dependent modulation and the electromechanical processes simulated by Variant 02, and also includes simulation of stretch and fibroblasts. This model is parameterised the same as the BASIC model, with all additional variables set to zero. The values for these variables can be found in <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9487284&dopt=Abstract">Noble et al.'s 1998 paper.</ulink> This model is also associated with a PCEnv session file.
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<title>Model Structure</title>
<para>In their 1998 paper, Denis Noble, Anthony Varghese, Peter Kohl and Penny Noble extended the guinea-pig ventricular cell model (originally developed in 1991 by Noble <emphasis>et al</emphasis>) to include accumulation and depletion of calcium in a diadic space between the sarcolemma and the sarcoplasmic reticulum, where the majority of calcium-induced calcium release is triggered. The model also includes rapid (i_Kr) and slow (i_Ks) components of the delayed rectifier current, and length- and tension-dependent changes in mechanical and electrophysiological processes have been incorporated (see <xref linkend="fig_cell_diagram"/> below). Drug-receptor interactions have also started to be modeled using the sodium channel as an example. The drugs used have the effect of blocking the inactivation h-gate of the fast sodium channel.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.pulsus.com/CARDIOL/14_01/nobl_ed.htm">Improved guinea-pig ventricular cell model incorporating a diadic space, I<subscript>Kr</subscript> and I<subscript>Ks</subscript>, and length- and tension-dependent processes</ulink>, Denis Noble, Anthony Varghese, Peter Kohl and Penelope Noble, 1998, <ulink url="http://www.pulsus.com/CARDIOL/home.htm">
<emphasis>Can J Cardiol</emphasis>
</ulink>, 14, 123-134. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9487284&dopt=Abstract">PubMed ID: 9487284</ulink>
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The raw CellML description of the Noble'98 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>. For an example of a more complete documentation for an electrophysiological model, see <ulink url="${HTML_EXMPL_HHSA_INTRO}">The Hodgkin-Huxley Squid Axon Model, 1952</ulink>.
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<title>cell diagram of Noble'98 model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
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<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Noble'98 model.</caption>
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To simulate multiple action potentials with this model the following integrator parameters must be used: max step size must be 0.001 or less, max point density must be 10,000 or more.</rdf:value>
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<dc:title>Canadian Journal of Cardiology</dc:title>
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<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
</rdf:RDF> <units name="per_millimolar">
<unit units="millimolar" exponent="-1"/>
</units>
<units name="per_second2">
<unit units="second" exponent="-2"/>
</units>
<units name="micrometre_per_second">
<unit units="micrometre"/>
<unit units="per_second"/>
</units>
<units name="micrometre_per_second2">
<unit units="micrometre"/>
<unit units="per_second2"/>
</units>
<units name="second_per_micrometre">
<unit units="second"/>
<unit units="per_micrometre"/>
</units>
<units name="millinewton">
<unit units="newton" prefix="milli"/>
</units>
<units name="millinewton_per_second">
<unit units="millinewton"/>
<unit units="per_second"/>
</units>
<units name="millinewton_second_per_micrometre">
<unit units="millinewton"/>
<unit units="second_per_micrometre"/>
</units>
<units name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units name="per_micrometre">
<unit units="micrometre" exponent="-1"/>
</units>
<units name="per_second">
<unit units="second" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="per_millivolt_second">
<unit units="millivolt" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="microS">
<unit units="siemens" prefix="micro"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="nanoA">
<unit units="ampere" prefix="nano"/>
</units>
<units name="mA_nA">
<unit units="ampere" prefix="milli"/>
<unit units="nanoA" exponent="-1"/>
</units>
<units name="nanoA_per_millimolar">
<unit units="ampere" prefix="nano"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar4">
<unit units="millimolar" exponent="4"/>
</units>
<units name="millimolar_per_second">
<unit units="millimolar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_millimolar_second">
<unit units="millimolar" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit units="mole" prefix="kilo" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="micrometre3">
<unit units="metre" prefix="micro" exponent="3"/>
</units>
<units name="litre_micrometre3">
<unit units="litre"/>
<unit units="micrometre3" exponent="-1"/>
</units>
<component name="environment">
<variable name="time" units="second" public_interface="out"/>
</component>
<component name="parameters">
<variable name="isotonic" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="alpha_1" units="per_micrometre" initial_value="14.6" public_interface="out"/>
<variable name="beta_1" units="millinewton" initial_value="0.84" public_interface="out"/>
<variable name="alpha_2" units="per_micrometre" initial_value="14.6" public_interface="out"/>
<variable name="beta_2" units="millinewton" initial_value="0.0018" public_interface="out"/>
<variable name="alpha_3" units="per_micrometre" initial_value="48" public_interface="out"/>
<variable name="beta_3" units="millinewton" initial_value="0.015" public_interface="out"/>
<variable name="lambda" units="millinewton" initial_value="30" public_interface="out"/>
<variable name="mu" units="dimensionless" initial_value="3" public_interface="out"/>
<variable name="k_mu" units="dimensionless" initial_value="0.6" public_interface="out"/>
<variable name="kappa" units="dimensionless" initial_value="0.705" public_interface="out"/>
<variable name="kappa_0" units="dimensionless" initial_value="3" public_interface="out"/>
<variable name="m_0" units="dimensionless" initial_value="0.9" public_interface="out"/>
<variable name="v_max" units="micrometre_per_second" initial_value="5.5" public_interface="out"/>
<variable name="a" units="dimensionless" initial_value="0.25" public_interface="out"/>
<variable name="d_h" units="dimensionless" initial_value="0.5" public_interface="out"/>
<variable name="alpha_P" units="dimensionless" initial_value="4" public_interface="out"/>
</component>
<component name="isotonic">
<variable name="isotonic" units="dimensionless" public_interface="in"/>
<variable name="l" units="micrometre" public_interface="in"/>
<variable name="F_muscle" units="millinewton" public_interface="in"/>
<variable name="F_afterload" units="millinewton" initial_value="2"/>
<variable name="isotonic_mode" units="dimensionless" public_interface="out"/>
<variable name="l_0" units="micrometre" public_interface="in"/>
<variable name="stim_period" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>isotonic_mode</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1</cn>
<apply>
<and/>
<apply>
<eq/>
<ci>isotonic</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<gt/>
<ci>F_muscle</ci>
<ci>F_afterload</ci>
</apply>
<apply>
<leq/>
<ci>l</ci>
<apply>
<times/>
<ci>l_0</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<cn type="e-notation" cellml:units="dimensionless">1 <sep/>
-4</cn>
</apply>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="parameters_izakov_et_al_1991">
<variable name="S_0" units="micrometre" initial_value="1.14" public_interface="out"/>
<variable name="q_v" units="per_second" public_interface="out"/>
<variable name="q_1" units="per_second" initial_value="17.3"/>
<variable name="q_2" units="per_second" initial_value="259"/>
<variable name="q_3" units="per_second" initial_value="17.3"/>
<variable name="q_4" units="per_second" initial_value="15" public_interface="out"/>
<variable name="x_st" units="dimensionless" initial_value="0.964285"/>
<variable name="v_st" units="micrometre_per_second" public_interface="out"/>
<variable name="v_1" units="micrometre_per_second" public_interface="out"/>
<variable name="alpha_G" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="k_A" units="per_millimolar" initial_value="40" public_interface="out"/>
<variable name="v" units="micrometre_per_second" public_interface="in"/>
<variable name="v_max" units="micrometre_per_second" public_interface="in"/>
<variable name="alpha_Q" units="dimensionless" initial_value="10"/>
<variable name="beta_Q" units="dimensionless" initial_value="5"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v_st</ci>
<apply>
<times/>
<ci>x_st</ci>
<ci>v_max</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_v</ci>
<piecewise>
<piece>
<apply>
<minus/>
<ci>q_1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>q_2</ci>
<ci>v</ci>
</apply>
<ci>v_max</ci>
</apply>
</apply>
<apply>
<leq/>
<ci>v</ci>
<cn cellml:units="micrometre_per_second">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>q_4</ci>
<ci>q_3</ci>
</apply>
<ci>v</ci>
</apply>
<ci>v_st</ci>
</apply>
<ci>q_3</ci>
</apply>
<apply>
<and/>
<apply>
<leq/>
<ci>v</ci>
<ci>v_st</ci>
</apply>
<apply>
<lt/>
<cn cellml:units="micrometre_per_second">0</cn>
<ci>v</ci>
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</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>q_4</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_Q</ci>
<apply>
<minus/>
<ci>v</ci>
<ci>v_st</ci>
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</apply>
<ci>v_max</ci>
</apply>
</apply>
<ci>alpha_Q</ci>
</apply>
</apply>
</otherwise>
</piecewise>
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<apply>
<eq/>
<ci>v_1</ci>
<apply>
<divide/>
<ci>v_max</ci>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
</math>
</component>
<component name="force">
<variable name="F_CE" units="millinewton"/>
<variable name="F_muscle" units="millinewton" public_interface="out"/>
<variable name="F_XSE" units="millinewton"/>
<variable name="F_SE" units="millinewton"/>
<variable name="F_PE" units="millinewton"/>
<variable name="N" units="dimensionless" public_interface="in"/>
<variable name="k_P_vis" units="millinewton_second_per_micrometre" public_interface="in"/>
<variable name="k_S_vis" units="millinewton_second_per_micrometre" public_interface="in"/>
<variable name="w" units="micrometre_per_second" public_interface="in"/>
<variable name="v" units="micrometre_per_second" public_interface="in"/>
<variable name="l_1" units="micrometre" public_interface="in"/>
<variable name="l_2" units="micrometre" public_interface="in"/>
<variable name="l_3" units="micrometre" public_interface="in"/>
<variable name="p_v" units="dimensionless" public_interface="in"/>
<variable name="alpha_1" units="per_micrometre" public_interface="in"/>
<variable name="beta_1" units="millinewton" public_interface="in"/>
<variable name="alpha_2" units="per_micrometre" public_interface="in"/>
<variable name="beta_2" units="millinewton" public_interface="in"/>
<variable name="alpha_3" units="per_micrometre" public_interface="in"/>
<variable name="beta_3" units="millinewton" public_interface="in"/>
<variable name="lambda" units="millinewton" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>F_CE</ci>
<apply>
<times/>
<ci>lambda</ci>
<ci>p_v</ci>
<ci>N</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>F_muscle</ci>
<ci>F_XSE</ci>
</apply>
<apply>
<eq/>
<ci>F_SE</ci>
<apply>
<times/>
<ci>beta_1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>F_PE</ci>
<apply>
<times/>
<ci>beta_2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>l_2</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>F_XSE</ci>
<apply>
<times/>
<ci>beta_3</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>l_3</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="crossbridge_kinetics">
<variable name="N" units="dimensionless" initial_value="7.455e-8" public_interface="out"/>
<variable name="K_kappa" units="per_second" public_interface="out"/>
<variable name="M_A" units="dimensionless"/>
<variable name="n_1" units="dimensionless"/>
<variable name="L_oz" units="dimensionless" public_interface="out"/>
<variable name="k_p_v" units="per_second"/>
<variable name="k_m_v" units="per_second"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="A" units="millimolar" public_interface="in"/>
<variable name="l_1" units="micrometre" public_interface="in"/>
<variable name="A_tot" units="millimolar" public_interface="in"/>
<variable name="mu" units="dimensionless" public_interface="in"/>
<variable name="k_mu" units="dimensionless" public_interface="in"/>
<variable name="kappa" units="dimensionless" public_interface="in"/>
<variable name="kappa_0" units="dimensionless" public_interface="in"/>
<variable name="m_0" units="dimensionless" public_interface="in"/>
<variable name="S_0" units="micrometre" public_interface="in"/>
<variable name="q_v" units="per_second" public_interface="in"/>
<variable name="v" units="micrometre_per_second" public_interface="in"/>
<variable name="v_st" units="micrometre_per_second" public_interface="in"/>
<variable name="G_star" units="dimensionless" public_interface="in"/>
<variable name="P_star" units="dimensionless" public_interface="in"/>
<variable name="q_4" units="per_second" public_interface="in"/>
<variable name="g_1" units="per_micrometre" initial_value="0.6"/>
<variable name="g_2" units="dimensionless" initial_value="0.52"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>M_A</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>A</ci>
<ci>A_tot</ci>
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<ci>mu</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<ci>k_mu</ci>
<ci>mu</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<divide/>
<ci>A</ci>
<ci>A_tot</ci>
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<ci>mu</ci>
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<apply>
<power/>
<ci>k_mu</ci>
<ci>mu</ci>
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</apply>
</apply>
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<eq/>
<ci>n_1</ci>
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<piece>
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<lt/>
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<plus/>
<apply>
<times/>
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<ci>g_2</ci>
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<cn cellml:units="dimensionless">0</cn>
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<plus/>
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<times/>
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<ci>l_1</ci>
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<ci>g_2</ci>
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<apply>
<lt/>
<apply>
<plus/>
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<times/>
<ci>g_1</ci>
<ci>l_1</ci>
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<ci>g_2</ci>
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<apply>
<eq/>
<ci>L_oz</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<plus/>
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<ci>S_0</ci>
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<apply>
<plus/>
<cn cellml:units="micrometre">0.46</cn>
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<apply>
<gt/>
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<times/>
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<plus/>
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<cn cellml:units="per_micrometre">1</cn>
</apply>
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<apply>
<eq/>
<ci>k_p_v</ci>
<apply>
<times/>
<ci>kappa</ci>
<ci>kappa_0</ci>
<ci>q_v</ci>
<ci>m_0</ci>
<ci>G_star</ci>
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</apply>
<apply>
<eq/>
<ci>k_m_v</ci>
<apply>
<times/>
<ci>kappa_0</ci>
<ci>q_v</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>kappa</ci>
<ci>m_0</ci>
<ci>G_star</ci>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_kappa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_p_v</ci>
<ci>M_A</ci>
<ci>n_1</ci>
<ci>L_oz</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>N</ci>
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<apply>
<times/>
<ci>k_m_v</ci>
<ci>N</ci>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>N</ci>
</apply>
<ci>K_kappa</ci>
</apply>
</math>
</component>
<component name="length">
<variable name="dl_1_dt" units="micrometre_per_second" public_interface="out"/>
<variable name="l_1" units="micrometre" initial_value="0.436333342969918" public_interface="out"/>
<variable name="dl_2_dt" units="micrometre_per_second" public_interface="out"/>
<variable name="l_2" units="micrometre" initial_value="0.436333525334166" public_interface="out"/>
<variable name="dl_3_dt" units="micrometre_per_second"/>
<variable name="l_3" units="micrometre" initial_value="0.088805830771694" public_interface="out"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="isotonic_mode" units="dimensionless" public_interface="in"/>
<variable name="v" units="micrometre_per_second" public_interface="in"/>
<variable name="w" units="micrometre_per_second" public_interface="in"/>
<variable name="l" units="micrometre" public_interface="out"/>
<variable name="k_S_vis" units="millinewton_second_per_micrometre" public_interface="in"/>
<variable name="phi_chi_2" units="micrometre_per_second" public_interface="in"/>
<variable name="stim_start" units="second" public_interface="in"/>
<variable name="stim_end" units="second" public_interface="in"/>
<variable name="stim_period" units="second" public_interface="in"/>
<variable name="stim_duration" units="second" public_interface="in"/>
<variable name="stim_amplitude" units="nanoA" public_interface="in"/>
<variable name="l_0" units="micrometre" initial_value="0.525139356105856" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>l</ci>
<apply>
<plus/>
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<ci>l_3</ci>
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<apply>
<eq/>
<ci>dl_1_dt</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
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<ci>dl_1_dt</ci>
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<apply>
<eq/>
<ci>dl_2_dt</ci>
<piecewise>
<piece>
<ci>phi_chi_2</ci>
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<eq/>
<ci>k_S_vis</ci>
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<ci>w</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>l_2</ci>
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<ci>dl_2_dt</ci>
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<apply>
<eq/>
<ci>dl_3_dt</ci>
<piecewise>
<piece>
<cn cellml:units="micrometre_per_second">0</cn>
<apply>
<eq/>
<ci>isotonic_mode</ci>
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<piece>
<apply>
<minus/>
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<apply>
<and/>
<apply>
<eq/>
<ci>isotonic_mode</ci>
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<apply>
<eq/>
<ci>k_S_vis</ci>
<cn cellml:units="millinewton_second_per_micrometre">0</cn>
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</apply>
</piece>
<piece>
<apply>
<minus/>
<ci>w</ci>
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<apply>
<and/>
<apply>
<eq/>
<ci>isotonic_mode</ci>
<cn cellml:units="dimensionless">0</cn>
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<apply>
<neq/>
<ci>k_S_vis</ci>
<cn cellml:units="millinewton_second_per_micrometre">0</cn>
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</apply>
</piece>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>l_3</ci>
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<piecewise>
<piece>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>l_2</ci>
<ci>l_3</ci>
</apply>
<ci>l_0</ci>
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</apply>
<ci>stim_duration</ci>
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<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
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<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<ci>dl_3_dt</ci>
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</piecewise>
</apply>
</math>
</component>
<component name="CE_velocity">
<variable name="v" units="micrometre_per_second" initial_value="0" public_interface="out"/>
<variable name="phi_chi" units="micrometre_per_second2" public_interface="out"/>
<variable name="phi_chi_2" units="micrometre_per_second" public_interface="out"/>
<variable name="k_P_vis" units="millinewton_second_per_micrometre" public_interface="out"/>
<variable name="k_S_vis" units="millinewton_second_per_micrometre" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="w" units="micrometre_per_second" public_interface="in"/>
<variable name="K_kappa" units="per_second" public_interface="in"/>
<variable name="N" units="dimensionless" public_interface="in"/>
<variable name="l_1" units="micrometre" public_interface="in"/>
<variable name="dl_1_dt" units="micrometre_per_second" public_interface="in"/>
<variable name="l_2" units="micrometre" public_interface="in"/>
<variable name="l_3" units="micrometre" public_interface="in"/>
<variable name="alpha_1" units="per_micrometre" public_interface="in"/>
<variable name="beta_1" units="millinewton" public_interface="in"/>
<variable name="alpha_2" units="per_micrometre" public_interface="in"/>
<variable name="beta_2" units="millinewton" public_interface="in"/>
<variable name="alpha_3" units="per_micrometre" public_interface="in"/>
<variable name="beta_3" units="millinewton" public_interface="in"/>
<variable name="lambda" units="millinewton" public_interface="in"/>
<variable name="isotonic_mode" units="dimensionless" public_interface="in"/>
<variable name="p_v" units="dimensionless" public_interface="in"/>
<variable name="p_prime_v" units="second_per_micrometre" public_interface="in"/>
<variable name="alpha_P_lengthening" units="per_micrometre" initial_value="16"/>
<variable name="beta_P_lengthening" units="millinewton_second_per_micrometre" initial_value="0.0015"/>
<variable name="alpha_P_shortening" units="per_micrometre" initial_value="16"/>
<variable name="beta_P_shortening" units="millinewton_second_per_micrometre" initial_value="0.0015"/>
<variable name="alp_p" units="per_micrometre"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alp_p</ci>
<piecewise>
<piece>
<ci>alpha_P_lengthening</ci>
<apply>
<leq/>
<ci>v</ci>
<cn cellml:units="micrometre_per_second">0</cn>
</apply>
</piece>
<otherwise>
<ci>alpha_P_shortening</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>k_P_vis</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>beta_P_lengthening</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_P_lengthening</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
<apply>
<leq/>
<ci>v</ci>
<cn cellml:units="micrometre_per_second">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>beta_P_shortening</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_P_shortening</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>phi_chi</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>lambda</ci>
<ci>K_kappa</ci>
<ci>p_v</ci>
</apply>
<apply>
<times/>
<ci>alp_p</ci>
<ci>k_P_vis</ci>
<apply>
<power/>
<ci>v</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>beta_2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>l_2</ci>
</apply>
</apply>
<ci>w</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>lambda</ci>
<ci>N</ci>
<ci>p_prime_v</ci>
</apply>
<ci>k_P_vis</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>isotonic_mode</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>lambda</ci>
<ci>K_kappa</ci>
<ci>p_v</ci>
</apply>
<apply>
<times/>
<ci>alp_p</ci>
<ci>k_P_vis</ci>
<apply>
<power/>
<ci>v</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>beta_2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>l_2</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>beta_3</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>l_3</ci>
</apply>
</apply>
</apply>
</apply>
<ci>w</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>lambda</ci>
<ci>N</ci>
<ci>p_prime_v</ci>
</apply>
<ci>k_P_vis</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>phi_chi_2</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>beta_1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
<ci>v</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>beta_1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>beta_2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>l_2</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>isotonic_mode</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>beta_1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
<ci>v</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>beta_1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>beta_2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>l_2</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>beta_3</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>l_3</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>v</ci>
</apply>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>beta_1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>phi_chi_2</ci>
<ci>v</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>lambda</ci>
<ci>K_kappa</ci>
<ci>p_v</ci>
</apply>
<apply>
<times/>
<ci>alp_p</ci>
<ci>k_P_vis</ci>
<apply>
<power/>
<ci>v</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>lambda</ci>
<ci>N</ci>
<ci>p_prime_v</ci>
</apply>
<ci>k_P_vis</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_S_vis</ci>
<cn cellml:units="millinewton_second_per_micrometre">0</cn>
</apply>
</piece>
<otherwise>
<ci>phi_chi</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="PE_velocity">
<variable name="w" units="micrometre_per_second" initial_value="0" public_interface="out"/>
<variable name="k_S_vis" units="millinewton_second_per_micrometre" public_interface="out"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="v" units="micrometre_per_second" public_interface="in"/>
<variable name="phi_chi" units="micrometre_per_second2" public_interface="in"/>
<variable name="l_1" units="micrometre" public_interface="in"/>
<variable name="dl_1_dt" units="micrometre_per_second" public_interface="in"/>
<variable name="l_2" units="micrometre" public_interface="in"/>
<variable name="dl_2_dt" units="micrometre_per_second" public_interface="in"/>
<variable name="l_3" units="micrometre" public_interface="in"/>
<variable name="alpha_1" units="per_micrometre" public_interface="in"/>
<variable name="beta_1" units="millinewton" public_interface="in"/>
<variable name="alpha_2" units="per_micrometre" public_interface="in"/>
<variable name="beta_2" units="millinewton" public_interface="in"/>
<variable name="alpha_3" units="per_micrometre" public_interface="in"/>
<variable name="beta_3" units="millinewton" public_interface="in"/>
<variable name="lambda" units="millinewton" public_interface="in"/>
<variable name="isotonic_mode" units="dimensionless" public_interface="in"/>
<variable name="alpha_S_lengthening" units="per_micrometre" initial_value="46"/>
<variable name="beta_S_lengthening" units="millinewton_second_per_micrometre" initial_value="0"/>
<variable name="alpha_S_shortening" units="per_micrometre" initial_value="39"/>
<variable name="beta_S_shortening" units="millinewton_second_per_micrometre" initial_value="0"/>
<variable name="alp_s" units="per_micrometre"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alp_s</ci>
<piecewise>
<piece>
<ci>alpha_S_lengthening</ci>
<apply>
<leq/>
<ci>w</ci>
<ci>v</ci>
</apply>
</piece>
<otherwise>
<ci>alpha_S_shortening</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>k_S_vis</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>beta_S_lengthening</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_S_lengthening</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<leq/>
<ci>w</ci>
<ci>v</ci>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>beta_S_shortening</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_S_shortening</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>w</ci>
</apply>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_S_vis</ci>
<apply>
<minus/>
<ci>phi_chi</ci>
<apply>
<times/>
<ci>alp_s</ci>
<apply>
<power/>
<apply>
<minus/>
<ci>w</ci>
<ci>v</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>beta_1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>w</ci>
<ci>v</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>beta_2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>l_2</ci>
</apply>
</apply>
<ci>w</ci>
</apply>
</apply>
<ci>k_S_vis</ci>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>isotonic_mode</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>k_S_vis</ci>
<cn cellml:units="millinewton_second_per_micrometre">0</cn>
</apply>
</apply>
</piece>
<piece>
<apply>
<minus/>
<apply>
<minus/>
<ci>phi_chi</ci>
<apply>
<times/>
<ci>alp_s</ci>
<apply>
<power/>
<apply>
<minus/>
<ci>w</ci>
<ci>v</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>beta_1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_1</ci>
<apply>
<minus/>
<ci>l_2</ci>
<ci>l_1</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>w</ci>
<ci>v</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>beta_2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>l_2</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>beta_3</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>l_3</ci>
</apply>
</apply>
</apply>
</apply>
<ci>w</ci>
</apply>
</apply>
<ci>k_S_vis</ci>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>isotonic_mode</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<neq/>
<ci>k_S_vis</ci>
<cn cellml:units="millinewton_second_per_micrometre">0</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="micrometre_per_second2">0</cn>
<apply>
<eq/>
<ci>k_S_vis</ci>
<cn cellml:units="millinewton_second_per_micrometre">0</cn>
</apply>
</piece>
</piecewise>
</apply>
</math>
</component>
<component name="average_crossbridge_force">
<variable name="p_v" units="dimensionless" public_interface="out"/>
<variable name="p_prime_v" units="second_per_micrometre" public_interface="out"/>
<variable name="P_star" units="dimensionless" public_interface="out"/>
<variable name="G_star" units="dimensionless" public_interface="out"/>
<variable name="gamma" units="dimensionless"/>
<variable name="case_1" units="second_per_micrometre"/>
<variable name="case_2" units="second_per_micrometre"/>
<variable name="case_3" units="second_per_micrometre"/>
<variable name="case_4" units="second_per_micrometre"/>
<variable name="v" units="micrometre_per_second" public_interface="in"/>
<variable name="phi_chi" units="micrometre_per_second2" public_interface="in"/>
<variable name="v_1" units="micrometre_per_second" public_interface="in"/>
<variable name="v_max" units="micrometre_per_second" public_interface="in"/>
<variable name="a" units="dimensionless" public_interface="in"/>
<variable name="d_h" units="dimensionless" public_interface="in"/>
<variable name="alpha_G" units="dimensionless" public_interface="in"/>
<variable name="alpha_P" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>a</ci>
<ci>d_h</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>v_1</ci>
<ci>v_max</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>a</ci>
<ci>d_h</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>a</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>v_1</ci>
</apply>
<ci>v_max</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_star</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>a</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>v</ci>
<ci>v_max</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>a</ci>
<apply>
<divide/>
<ci>v</ci>
<ci>v_max</ci>
</apply>
</apply>
</apply>
<apply>
<leq/>
<ci>v</ci>
<cn cellml:units="micrometre_per_second">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<minus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>d_h</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<ci>d_h</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>a</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>a</ci>
<ci>d_h</ci>
</apply>
<ci>gamma</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>v</ci>
<ci>v_max</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>a</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>v</ci>
</apply>
<ci>v_max</ci>
</apply>
<apply>
<times/>
<ci>a</ci>
<ci>d_h</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>G_star</ci>
<piecewise>
<piece>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.6</cn>
<ci>v</ci>
</apply>
<ci>v_max</ci>
</apply>
</apply>
<apply>
<and/>
<apply>
<leq/>
<apply>
<minus/>
<ci>v_max</ci>
</apply>
<ci>v</ci>
</apply>
<apply>
<leq/>
<ci>v</ci>
<cn cellml:units="micrometre_per_second">0</cn>
</apply>
</apply>
</piece>
<piece>
<apply>
<divide/>
<ci>P_star</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>a</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>v</ci>
</apply>
<apply>
<times/>
<ci>a</ci>
<ci>v_max</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<cn cellml:units="micrometre_per_second">0</cn>
<ci>v</ci>
</apply>
<apply>
<leq/>
<ci>v</ci>
<ci>v_1</ci>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>P_star</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>alpha_G</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<minus/>
<ci>v</ci>
<ci>v_1</ci>
</apply>
<ci>v_max</ci>
</apply>
<ci>alpha_P</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>a</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>v</ci>
</apply>
<apply>
<times/>
<ci>a</ci>
<ci>v_max</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>case_1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>a</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.4</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>a</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>v_max</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<plus/>
<ci>a</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">0.4</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>case_2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>a</ci>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>a</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.2</cn>
<ci>v</ci>
</apply>
<ci>v_max</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>v</ci>
<ci>v_max</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>v_max</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<minus/>
<ci>a</ci>
<apply>
<divide/>
<ci>v</ci>
<ci>v_max</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.6</cn>
<ci>v</ci>
</apply>
<ci>v_max</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>case_3</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>a</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>a</ci>
<ci>v_max</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>case_4</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_max</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>alpha_G</ci>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<divide/>
<ci>v</ci>
<ci>v_max</ci>
</apply>
<apply>
<divide/>
<ci>v_1</ci>
<ci>v_max</ci>
</apply>
</apply>
<ci>alpha_P</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>a</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>a</ci>
</apply>
<apply>
<times/>
<ci>alpha_G</ci>
<ci>alpha_P</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>a</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>v</ci>
</apply>
<apply>
<times/>
<ci>a</ci>
<ci>v_max</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<divide/>
<ci>v</ci>
<ci>v_max</ci>
</apply>
<apply>
<divide/>
<ci>v_1</ci>
<ci>v_max</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>alpha_P</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_v</ci>
<apply>
<divide/>
<ci>P_star</ci>
<ci>G_star</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_prime_v</ci>
<piecewise>
<piece>
<ci>case_1</ci>
<apply>
<leq/>
<ci>v</ci>
<apply>
<minus/>
<ci>v_max</ci>
</apply>
</apply>
</piece>
<piece>
<ci>case_2</ci>
<apply>
<and/>
<apply>
<lt/>
<apply>
<minus/>
<ci>v_max</ci>
</apply>
<ci>v</ci>
</apply>
<apply>
<leq/>
<ci>v</ci>
<cn cellml:units="micrometre_per_second">0</cn>
</apply>
</apply>
</piece>
<piece>
<ci>case_3</ci>
<apply>
<and/>
<apply>
<lt/>
<cn cellml:units="micrometre_per_second">0</cn>
<ci>v</ci>
</apply>
<apply>
<leq/>
<ci>v</ci>
<ci>v_1</ci>
</apply>
</apply>
</piece>
<otherwise>
<ci>case_4</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="membrane">
<variable name="V" units="millivolt" initial_value="-93.658148" public_interface="out"/>
<variable name="R" units="joule_per_kilomole_kelvin" initial_value="8314.472" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="310" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" initial_value="96485.3415" public_interface="out"/>
<variable name="Cm" units="microF" initial_value="9.5e-5"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="i_K1" units="nanoA" public_interface="in"/>
<variable name="i_to" units="nanoA" public_interface="in"/>
<variable name="i_Kr" units="nanoA" public_interface="in"/>
<variable name="i_Ks" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_K_cyt" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_K_ds" units="nanoA" public_interface="in"/>
<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="i_Na" units="nanoA" public_interface="in"/>
<variable name="i_b_Na" units="nanoA" public_interface="in"/>
<variable name="i_p_Na" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Na_cyt" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Na_ds" units="nanoA" public_interface="in"/>
<variable name="i_NaCa_cyt" units="nanoA" public_interface="in"/>
<variable name="i_NaCa_ds" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Ca_cyt" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Ca_ds" units="nanoA" public_interface="in"/>
<variable name="i_b_Ca" units="nanoA" public_interface="in"/>
<variable name="i_Stim" units="nanoA"/>
<variable name="stim_start" units="second" initial_value="0.06" public_interface="out"/>
<variable name="stim_end" units="second" initial_value="10000" public_interface="out"/>
<variable name="stim_period" units="second" initial_value="1" public_interface="out"/>
<variable name="stim_duration" units="second" initial_value="0.0025" public_interface="out"/>
<variable name="stim_amplitude" units="nanoA" initial_value="-3" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="nanoA">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>i_Stim</ci>
<ci>i_K1</ci>
<ci>i_to</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_NaK</ci>
<ci>i_Na</ci>
<ci>i_b_Na</ci>
<ci>i_p_Na</ci>
<ci>i_Ca_L_Na_cyt</ci>
<ci>i_Ca_L_Na_ds</ci>
<ci>i_NaCa_cyt</ci>
<ci>i_NaCa_ds</ci>
<ci>i_Ca_L_Ca_cyt</ci>
<ci>i_Ca_L_Ca_ds</ci>
<ci>i_Ca_L_K_cyt</ci>
<ci>i_Ca_L_K_ds</ci>
<ci>i_b_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="reversal_potentials">
<variable name="E_Na" units="millivolt" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="E_Ks" units="millivolt" public_interface="out"/>
<variable name="E_Ca" units="millivolt" public_interface="out"/>
<variable name="E_mh" units="millivolt" public_interface="out"/>
<variable name="P_kna" units="dimensionless" initial_value="0.03"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>K_o</ci>
<apply>
<times/>
<ci>P_kna</ci>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>K_i</ci>
<apply>
<times/>
<ci>P_kna</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_mh</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Na_o</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>K_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Na_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable name="i_K1" units="nanoA" public_interface="out"/>
<variable name="K_mk1" units="millimolar" initial_value="10" public_interface="out"/>
<variable name="g_K1" units="microS" initial_value="0.5"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>K_mk1</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">1.25</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_potassium_current">
<variable name="i_Kr" units="nanoA" public_interface="out"/>
<variable name="g_Kr1" units="microS" initial_value="0.0021"/>
<variable name="g_Kr2" units="microS" initial_value="0.0013"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="xr1" units="dimensionless" private_interface="in"/>
<variable name="xr2" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>g_Kr1</ci>
<ci>xr1</ci>
</apply>
<apply>
<times/>
<ci>g_Kr2</ci>
<ci>xr2</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">9</cn>
</apply>
<cn cellml:units="millivolt">22.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_potassium_current_xr1_gate">
<variable name="xr1" units="dimensionless" initial_value="8.88859784542779e-6" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="alpha_xr1" units="per_second"/>
<variable name="beta_xr1" units="per_second"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_xr1</ci>
<apply>
<divide/>
<cn cellml:units="per_second">50</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xr1</ci>
<apply>
<times/>
<cn cellml:units="per_second">0.05</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xr1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_xr1</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>xr1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_xr1</ci>
<ci>xr1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_potassium_current_xr2_gate">
<variable name="xr2" units="dimensionless" initial_value="1.53745791069154e-7" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="alpha_xr2" units="per_second"/>
<variable name="beta_xr2" units="per_second"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_xr2</ci>
<apply>
<divide/>
<cn cellml:units="per_second">50</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xr2</ci>
<apply>
<times/>
<cn cellml:units="per_second">0.4</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xr2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_xr2</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>xr2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_xr2</ci>
<ci>xr2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifier_potassium_current">
<variable name="i_Ks" units="nanoA" public_interface="out"/>
<variable name="g_Ks" units="microS" initial_value="0.0026"/>
<variable name="E_Ks" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="xs" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<power/>
<ci>xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifier_potassium_current_xs_gate">
<variable name="xs" units="dimensionless" initial_value="0.001" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="alpha_xs" units="per_second"/>
<variable name="beta_xs" units="per_second"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_xs</ci>
<apply>
<divide/>
<cn cellml:units="per_second">14</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xs</ci>
<apply>
<times/>
<cn cellml:units="per_second">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">45</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xs</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_xs</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>xs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_xs</ci>
<ci>xs</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_activated_potassium_current">
<variable name="i_KNa" units="nanoA" public_interface="out"/>
<variable name="g_K_Na" units="microS" initial_value="0"/>
<variable name="K_kna" units="millimolar" initial_value="20"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KNa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K_Na</ci>
<ci>Na_i</ci>
</apply>
<apply>
<plus/>
<ci>Na_i</ci>
<ci>K_kna</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current">
<variable name="i_Na" units="nanoA" public_interface="out"/>
<variable name="g_Na" units="microS" initial_value="2.5"/>
<variable name="E_mh" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_m_gate">
<variable name="m" units="dimensionless" initial_value="0.0015" public_interface="out"/>
<variable name="alpha_m" units="per_second"/>
<variable name="beta_m" units="per_second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="delta_m" units="millivolt" initial_value="1e-5"/>
<variable name="E0_m" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E0_m</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">41</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">2000</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_m</ci>
</apply>
<ci>delta_m</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">200</cn>
<ci>E0_m</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<ci>E0_m</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_second">8000</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.056</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">66</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_h_gate">
<variable name="h" units="dimensionless" initial_value="0.995" public_interface="out"/>
<variable name="alpha_h" units="per_second"/>
<variable name="beta_h" units="per_second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn cellml:units="per_second">20</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.125</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn cellml:units="per_second">2000</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">320</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="persistent_sodium_current">
<variable name="i_p_Na" units="nanoA" public_interface="out"/>
<variable name="g_pna" units="microS" initial_value="0.004"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_p_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_pna</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">52</cn>
</apply>
</apply>
<cn cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable name="i_b_Na" units="nanoA" public_interface="out"/>
<variable name="g_bna" units="microS" initial_value="0.0006"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Na</ci>
<apply>
<times/>
<ci>g_bna</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel">
<variable name="i_Ca_L_Ca_cyt" units="nanoA" public_interface="out"/>
<variable name="i_Ca_L_K_cyt" units="nanoA" public_interface="out"/>
<variable name="i_Ca_L_Na_cyt" units="nanoA" public_interface="out"/>
<variable name="i_Ca_L_Ca_ds" units="nanoA" public_interface="out"/>
<variable name="i_Ca_L_K_ds" units="nanoA" public_interface="out"/>
<variable name="i_Ca_L_Na_ds" units="nanoA" public_interface="out"/>
<variable name="i_Ca_L" units="nanoA" public_interface="out"/>
<variable name="P_Ca_L" units="nanoA_per_millimolar" initial_value="0.1"/>
<variable name="P_CaK" units="dimensionless" initial_value="0.002"/>
<variable name="P_CaNa" units="dimensionless" initial_value="0.01"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_ds" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="d" units="dimensionless" private_interface="in"/>
<variable name="f" units="dimensionless" private_interface="in"/>
<variable name="f2" units="dimensionless" private_interface="in"/>
<variable name="f2ds" units="dimensionless" private_interface="in"/>
<variable name="Km_f2" units="millimolar" initial_value="100000" private_interface="out"/>
<variable name="Km_f2ds" units="millimolar" initial_value="0.001" private_interface="out"/>
<variable name="R_decay" units="per_second" initial_value="20" public_interface="out" private_interface="out"/>
<variable name="FrICa" units="dimensionless" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_L_Ca_cyt</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FrICa</ci>
</apply>
<cn cellml:units="dimensionless">4</cn>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">100</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_K_cyt</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FrICa</ci>
</apply>
<ci>P_CaK</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>K_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_Na_cyt</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FrICa</ci>
</apply>
<ci>P_CaNa</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Na_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Na_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_Ca_ds</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>FrICa</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2ds</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">100</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_K_ds</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>FrICa</ci>
<ci>P_CaK</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2ds</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>K_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_Na_ds</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>FrICa</ci>
<ci>P_CaNa</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2ds</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Na_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Na_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L</ci>
<apply>
<plus/>
<ci>i_Ca_L_Ca_cyt</ci>
<ci>i_Ca_L_K_cyt</ci>
<ci>i_Ca_L_Na_cyt</ci>
<ci>i_Ca_L_Ca_ds</ci>
<ci>i_Ca_L_K_ds</ci>
<ci>i_Ca_L_Na_ds</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_d_gate">
<variable name="d" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="alpha_d" units="per_second"/>
<variable name="beta_d" units="per_second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="E0_d" units="millivolt"/>
<variable name="speed_d" units="dimensionless" initial_value="3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E0_d</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">24</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_d</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">120</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_d</ci>
</apply>
<cn cellml:units="millivolt">0.0001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">30</cn>
<ci>E0_d</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>E0_d</ci>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_d</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">120</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_d</ci>
</apply>
<cn cellml:units="millivolt">0.0001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">12</cn>
<ci>E0_d</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>E0_d</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<times/>
<ci>speed_d</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_d</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>d</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_d</ci>
<ci>d</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f_gate">
<variable name="f" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="alpha_f" units="per_second"/>
<variable name="beta_f" units="per_second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="speed_f" units="dimensionless" initial_value="0.3"/>
<variable name="delta_f" units="millivolt" initial_value="0.0001"/>
<variable name="E0_f" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E0_f</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">34</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_f</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">25</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_f</ci>
</apply>
<ci>delta_f</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">6.25</cn>
<ci>E0_f</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>E0_f</ci>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_f</ci>
<apply>
<divide/>
<cn cellml:units="per_second">12</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">34</cn>
</apply>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<times/>
<ci>speed_f</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_f</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>f</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_f</ci>
<ci>f</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f2_gate">
<variable name="f2" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="Km_f2" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f2</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="per_second">1</cn>
<apply>
<times/>
<cn cellml:units="per_second">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<ci>Ca_i</ci>
<apply>
<plus/>
<ci>Km_f2</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<ci>f2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f2ds_gate">
<variable name="f2ds" units="dimensionless" initial_value="0.997" public_interface="out"/>
<variable name="Km_f2ds" units="millimolar" public_interface="in"/>
<variable name="R_decay" units="per_second" public_interface="in"/>
<variable name="Ca_ds" units="millimolar" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f2ds</ci>
</apply>
<apply>
<times/>
<ci>R_decay</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<ci>Ca_ds</ci>
<apply>
<plus/>
<ci>Km_f2ds</ci>
<ci>Ca_ds</ci>
</apply>
</apply>
<ci>f2ds</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable name="i_b_Ca" units="nanoA" public_interface="out"/>
<variable name="g_bca" units="microS" initial_value="0.00025"/>
<variable name="E_Ca" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Ca</ci>
<apply>
<times/>
<ci>g_bca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current">
<variable name="i_to" units="nanoA" public_interface="out"/>
<variable name="g_to" units="microS" initial_value="0.006"/>
<variable name="g_tos" units="dimensionless" initial_value="0"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="s" units="dimensionless" private_interface="in"/>
<variable name="r" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<times/>
<ci>g_to</ci>
<apply>
<plus/>
<ci>g_tos</ci>
<apply>
<times/>
<ci>s</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>g_tos</ci>
</apply>
</apply>
</apply>
<ci>r</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_s_gate">
<variable name="s" units="dimensionless" initial_value="0.997044616031121" public_interface="out"/>
<variable name="alpha_s" units="per_second"/>
<variable name="beta_s" units="per_second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_s</ci>
<apply>
<times/>
<cn cellml:units="per_second">0.033</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_s</ci>
<apply>
<divide/>
<cn cellml:units="per_second">33</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.125</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_s</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>s</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_s</ci>
<ci>s</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_r_gate">
<variable name="r" units="dimensionless" initial_value="1.63117173173398e-8" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">333</cn>
<apply>
<minus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<ci>r</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable name="i_NaK" units="nanoA" public_interface="out"/>
<variable name="i_NaK_max" units="nanoA" initial_value="0.7"/>
<variable name="K_mK" units="millimolar" initial_value="1"/>
<variable name="K_mNa" units="millimolar" initial_value="24.2"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_mK</ci>
<ci>K_o</ci>
</apply>
</apply>
<ci>Na_i</ci>
</apply>
<apply>
<plus/>
<ci>K_mNa</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger">
<variable name="i_NaCa" units="nanoA" public_interface="out"/>
<variable name="i_NaCa_cyt" units="nanoA" public_interface="out"/>
<variable name="i_NaCa_ds" units="nanoA" public_interface="out"/>
<variable name="k_NaCa" units="nanoA" initial_value="0.0005"/>
<variable name="n_NaCa" units="dimensionless" initial_value="3" public_interface="out"/>
<variable name="d_NaCa" units="dimensionless" initial_value="0"/>
<variable name="gamma" units="dimensionless" initial_value="0.5"/>
<variable name="FRiNaCa" units="dimensionless" initial_value="0.001"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_ds" units="millimolar" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa_cyt</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FRiNaCa</ci>
</apply>
<ci>k_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="millimolar4">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0069</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa_ds</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>FRiNaCa</ci>
<ci>k_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_ds</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="millimolar4">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_ds</ci>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_ds</ci>
<cn cellml:units="millimolar">0.0069</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<plus/>
<ci>i_NaCa_cyt</ci>
<ci>i_NaCa_ds</ci>
</apply>
</apply>
</math>
</component>
<component name="sarcoplasmic_reticulum_calcium_pump">
<variable name="i_up" units="millimolar_per_second" public_interface="out"/>
<variable name="K_1" units="dimensionless"/>
<variable name="K_2" units="millimolar"/>
<variable name="K_cyca" units="millimolar" initial_value="0.00015"/>
<variable name="K_xcs" units="dimensionless" initial_value="0.4"/>
<variable name="K_srca" units="millimolar" initial_value="0.5"/>
<variable name="alpha_up" units="millimolar_per_second" initial_value="1"/>
<variable name="beta_up" units="millimolar_per_second" initial_value="0.03"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_up" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="flag_ingib" units="dimensionless" initial_value="0"/>
<variable name="K_inh" units="millimolar" initial_value="4"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_srca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>K_2</ci>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<apply>
<times/>
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_cyca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_up</ci>
<piecewise>
<piece>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_i</ci>
<ci>K_2</ci>
</apply>
<ci>alpha_up</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<ci>K_2</ci>
</apply>
<ci>beta_up</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>flag_ingib</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_i</ci>
<ci>K_2</ci>
</apply>
<ci>alpha_up</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_up</ci>
<ci>K_inh</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<ci>K_2</ci>
</apply>
<ci>beta_up</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="calcium_translocation">
<variable name="i_trans" units="millimolar_per_second" public_interface="out"/>
<variable name="Ca_rel" units="millimolar" public_interface="in"/>
<variable name="Ca_up" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="a_tr" units="per_second" initial_value="15"/>
<variable name="alpha_CaS" units="per_millimolar_second" initial_value="50000"/>
<variable name="beta_CaS" units="per_second" initial_value="32500"/>
<variable name="CaS_tot" units="millimolar" initial_value="40" public_interface="out"/>
<variable name="beta" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_trans</ci>
<apply>
<times/>
<ci>a_tr</ci>
<apply>
<minus/>
<ci>Ca_up</ci>
<ci>Ca_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<divide/>
<ci>beta_CaS</ci>
<ci>alpha_CaS</ci>
</apply>
</apply>
</math>
</component>
<component name="calcium_release">
<variable name="i_rel" units="millimolar_per_second" public_interface="out"/>
<variable name="VoltDep" units="dimensionless"/>
<variable name="RegBindSite" units="dimensionless"/>
<variable name="CaiReg" units="dimensionless"/>
<variable name="CadsReg" units="dimensionless"/>
<variable name="ActRate" units="per_second"/>
<variable name="InactRate" units="per_second"/>
<variable name="SRLeak" units="per_second" initial_value="0.05"/>
<variable name="K_m_rel" units="per_second" initial_value="10000"/>
<variable name="K_m_Ca_cyt" units="millimolar" initial_value="0.0005"/>
<variable name="K_m_Ca_ds" units="millimolar" initial_value="0.01"/>
<variable name="PrecFrac" units="dimensionless"/>
<variable name="ActFrac" units="dimensionless" initial_value="0.001914"/>
<variable name="ProdFrac" units="dimensionless" initial_value="0.2854569"/>
<variable name="SpeedRel" units="dimensionless"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_ds" units="millimolar" public_interface="in"/>
<variable name="Ca_rel" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>VoltDep</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.08</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaiReg</ci>
<apply>
<divide/>
<ci>Ca_i</ci>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>K_m_Ca_cyt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CadsReg</ci>
<apply>
<divide/>
<ci>Ca_ds</ci>
<apply>
<plus/>
<ci>Ca_ds</ci>
<ci>K_m_Ca_ds</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RegBindSite</ci>
<apply>
<plus/>
<ci>CaiReg</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>CaiReg</ci>
</apply>
<ci>CadsReg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ActRate</ci>
<apply>
<times/>
<cn cellml:units="per_second">500</cn>
<apply>
<power/>
<ci>RegBindSite</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>InactRate</ci>
<apply>
<plus/>
<cn cellml:units="per_second">60</cn>
<apply>
<times/>
<cn cellml:units="per_second">500</cn>
<apply>
<power/>
<ci>RegBindSite</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>SpeedRel</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">5</cn>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>PrecFrac</ci>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>ActFrac</ci>
</apply>
<ci>ProdFrac</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ActFrac</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>PrecFrac</ci>
<ci>SpeedRel</ci>
<ci>ActRate</ci>
</apply>
<apply>
<times/>
<ci>ActFrac</ci>
<ci>SpeedRel</ci>
<ci>InactRate</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ProdFrac</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ActFrac</ci>
<ci>SpeedRel</ci>
<ci>InactRate</ci>
</apply>
<apply>
<times/>
<ci>SpeedRel</ci>
<cn cellml:units="per_second">0.6</cn>
<ci>ProdFrac</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_rel</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>ActFrac</ci>
<apply>
<plus/>
<ci>ActFrac</ci>
<cn cellml:units="dimensionless">0.25</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>K_m_rel</ci>
</apply>
<ci>SRLeak</ci>
</apply>
<ci>Ca_rel</ci>
</apply>
</apply>
</math>
</component>
<component name="extracellular_sodium_concentration">
<variable name="Na_o" units="millimolar" initial_value="140" public_interface="out"/>
</component>
<component name="intracellular_sodium_concentration">
<variable name="Na_i" units="millimolar" initial_value="5.18787513289509" public_interface="out"/>
<variable name="V_i" units="micrometre3" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="i_Na" units="nanoA" public_interface="in"/>
<variable name="i_b_Na" units="nanoA" public_interface="in"/>
<variable name="i_p_Na" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Na_cyt" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Na_ds" units="nanoA" public_interface="in"/>
<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="i_NaCa_cyt" units="nanoA" public_interface="in"/>
<variable name="n_NaK" units="dimensionless" initial_value="1.5" public_interface="out"/>
<variable name="n_NaCa" units="dimensionless" public_interface="in"/>
<variable name="i_NaCa" units="nanoA" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_p_Na</ci>
<ci>i_b_Na</ci>
<ci>i_Ca_L_Na_cyt</ci>
<ci>i_Ca_L_Na_ds</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>n_NaK</ci>
<apply>
<minus/>
<ci>n_NaK</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>i_NaK</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>n_NaCa</ci>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_calcium_concentration">
<variable name="Ca_o" units="millimolar" initial_value="2" public_interface="out"/>
</component>
<component name="extracellular_potassium_concentration">
<variable name="K_o" units="millimolar" initial_value="3.988" public_interface="out"/>
<variable name="K_b" units="millimolar" initial_value="4"/>
<variable name="i_Kr" units="nanoA" public_interface="in"/>
<variable name="i_Ks" units="nanoA" public_interface="in"/>
<variable name="i_K1" units="nanoA" public_interface="in"/>
<variable name="i_to" units="nanoA" public_interface="in"/>
<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_K_cyt" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_K_ds" units="nanoA" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="n_NaK" units="dimensionless" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="V_e" units="micrometre3" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_o</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="mA_nA">1</cn>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_K1</ci>
<ci>i_to</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<minus/>
<ci>n_NaK</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>i_NaK</ci>
</apply>
</apply>
<ci>i_Ca_L_K_cyt</ci>
<ci>i_Ca_L_K_ds</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_e</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">0.7</cn>
<apply>
<minus/>
<ci>K_o</ci>
<ci>K_b</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_potassium_concentration">
<variable name="K_i" units="millimolar" initial_value="139.054" public_interface="out"/>
<variable name="V_i" units="micrometre3" public_interface="in"/>
<variable name="i_K1" units="nanoA" public_interface="in"/>
<variable name="i_Kr" units="nanoA" public_interface="in"/>
<variable name="i_Ks" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_K_cyt" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_K_ds" units="nanoA" public_interface="in"/>
<variable name="i_to" units="nanoA" public_interface="in"/>
<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="n_NaK" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_K1</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_Ca_L_K_cyt</ci>
<ci>i_Ca_L_K_ds</ci>
<ci>i_to</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<minus/>
<ci>n_NaK</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>i_NaK</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_calcium_concentration">
<variable name="Ca_i" units="millimolar" initial_value="6.15e-6" public_interface="out"/>
<variable name="Ca_ds" units="millimolar" initial_value="2.55e-6" public_interface="out"/>
<variable name="Ca_up" units="millimolar" initial_value="0.994579" public_interface="out"/>
<variable name="Ca_rel" units="millimolar" initial_value="0.989665" public_interface="out"/>
<variable name="radius" units="micrometre" initial_value="12"/>
<variable name="length" units="micrometre" initial_value="74"/>
<variable name="V_i" units="micrometre3" public_interface="out"/>
<variable name="V_e" units="micrometre3" public_interface="out"/>
<variable name="V_Cell" units="micrometre3"/>
<variable name="V_i_ratio" units="dimensionless" initial_value="0.49"/>
<variable name="V_ds_ratio" units="dimensionless" initial_value="0.1"/>
<variable name="V_rel_ratio" units="dimensionless" initial_value="0.003"/>
<variable name="V_e_ratio" units="dimensionless" initial_value="0.4"/>
<variable name="V_up_ratio" units="dimensionless" initial_value="0.03"/>
<variable name="Kdecay" units="per_second" initial_value="10"/>
<variable name="i_up" units="millimolar_per_second" public_interface="in"/>
<variable name="i_trans" units="millimolar_per_second" public_interface="in"/>
<variable name="i_rel" units="millimolar_per_second" public_interface="in"/>
<variable name="i_NaCa_cyt" units="nanoA" public_interface="in"/>
<variable name="i_NaCa_ds" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Ca_cyt" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L_Ca_ds" units="nanoA" public_interface="in"/>
<variable name="i_b_Ca" units="nanoA" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="A" units="millimolar" initial_value="0.00015" public_interface="out"/>
<variable name="N_A" units="dimensionless"/>
<variable name="pi_N_A" units="dimensionless"/>
<variable name="pi_min" units="dimensionless" initial_value="0.03"/>
<variable name="N" units="dimensionless" public_interface="in"/>
<variable name="a_on" units="per_millimolar_second" initial_value="70000"/>
<variable name="a_off" units="per_second" initial_value="200"/>
<variable name="k_A" units="per_millimolar" public_interface="in"/>
<variable name="L_oz" units="dimensionless" public_interface="in"/>
<variable name="A_tot" units="millimolar" initial_value="0.07" public_interface="out"/>
<variable name="B_1" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="B_1_tot" units="millimolar" initial_value="0.08"/>
<variable name="b_1_on" units="per_millimolar_second" initial_value="100000"/>
<variable name="b_1_off" units="per_second" initial_value="182"/>
<variable name="B_2" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="B_2_tot" units="millimolar" initial_value="0.1"/>
<variable name="b_2_on" units="per_millimolar_second" initial_value="1000"/>
<variable name="b_2_off" units="per_second" initial_value="3"/>
<variable name="CaS_tot" units="millimolar" public_interface="in"/>
<variable name="beta" units="millimolar" public_interface="in"/>
<variable name="n_NaCa" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>N_A</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>A_tot</ci>
<ci>N</ci>
</apply>
<apply>
<times/>
<ci>L_oz</ci>
<ci>A</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pi_N_A</ci>
<piecewise>
<piece>
<ci>pi_min</ci>
<apply>
<leq/>
<ci>N_A</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<power/>
<ci>pi_min</ci>
<ci>N_A</ci>
</apply>
<apply>
<leq/>
<ci>N_A</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>A</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>a_on</ci>
<apply>
<minus/>
<ci>A_tot</ci>
<ci>A</ci>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>a_off</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>k_A</ci>
</apply>
<ci>A</ci>
</apply>
</apply>
<ci>pi_N_A</ci>
<ci>A</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>B_1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>b_1_on</ci>
<apply>
<minus/>
<ci>B_1_tot</ci>
<ci>B_1</ci>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>b_1_off</ci>
<ci>B_1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>B_2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>b_2_on</ci>
<apply>
<minus/>
<ci>B_2_tot</ci>
<ci>B_2</ci>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>b_2_off</ci>
<ci>B_2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_Cell</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3.141592654</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>radius</ci>
<cn cellml:units="dimensionless">1000</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>length</ci>
</apply>
<cn cellml:units="dimensionless">1000</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>V_i</ci>
<apply>
<times/>
<ci>V_Cell</ci>
<ci>V_i_ratio</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_e</ci>
<apply>
<times/>
<ci>V_Cell</ci>
<ci>V_e_ratio</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Ca_L_Ca_cyt</ci>
<ci>i_b_Ca</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>i_NaCa_cyt</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_ds</ci>
<ci>V_ds_ratio</ci>
<ci>Kdecay</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>i_rel</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>V_i_ratio</ci>
</apply>
</apply>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>A</ci>
</apply>
</apply>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>B_1</ci>
</apply>
</apply>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>B_2</ci>
</apply>
</apply>
<ci>i_up</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_ds</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<ci>i_Ca_L_Ca_ds</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="mA_nA">2</cn>
<ci>i_NaCa_ds</ci>
</apply>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_ds_ratio</ci>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_ds</ci>
<ci>Kdecay</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_up</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>V_i_ratio</ci>
<ci>V_up_ratio</ci>
</apply>
<ci>i_up</ci>
</apply>
<ci>i_trans</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_rel</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>V_up_ratio</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>i_trans</ci>
</apply>
<ci>i_rel</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>beta</ci>
<ci>CaS_tot</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_rel</ci>
<ci>beta</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fibroblast">
<variable name="g_fibro_junct" units="microS" initial_value="2.9e-4"/>
<variable name="g_fibro" units="microS" initial_value="2e-4"/>
<variable name="c_fibro" units="microF" initial_value="1e-5"/>
<variable name="g_fibro_stretch" units="microS" initial_value="0"/>
<variable name="E_fibro_stretch" units="millivolt" initial_value="0"/>
<variable name="V_fibro" units="millivolt" initial_value="-20"/>
<variable name="i_fibro" units="nanoA"/>
<variable name="i_fibro_junct" units="nanoA"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_fibro</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>g_fibro</ci>
<apply>
<plus/>
<ci>V_fibro</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
<apply>
<times/>
<ci>g_fibro_stretch</ci>
<apply>
<minus/>
<ci>V_fibro</ci>
<ci>E_fibro_stretch</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fibro_junct</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>g_fibro_junct</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>V_fibro</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V_fibro</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_fibro</ci>
<ci>i_fibro_junct</ci>
</apply>
</apply>
<ci>c_fibro</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f2_gate"/>
<component_ref component="L_type_Ca_channel_f2ds_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_potassium_current">
<component_ref component="rapid_delayed_rectifier_potassium_current_xr1_gate"/>
<component_ref component="rapid_delayed_rectifier_potassium_current_xr2_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_potassium_current">
<component_ref component="slow_delayed_rectifier_potassium_current_xs_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current"/>
<component_ref component="sodium_activated_potassium_current"/>
<component_ref component="persistent_sodium_current"/>
<component_ref component="sodium_background_current"/>
<component_ref component="calcium_background_current"/>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_s_gate"/>
<component_ref component="transient_outward_current_r_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="sodium_calcium_exchanger"/>
<component_ref component="sarcoplasmic_reticulum_calcium_pump"/>
<component_ref component="calcium_translocation"/>
<component_ref component="calcium_release"/>
<component_ref component="extracellular_sodium_concentration"/>
<component_ref component="intracellular_sodium_concentration"/>
<component_ref component="extracellular_potassium_concentration"/>
<component_ref component="intracellular_potassium_concentration"/>
<component_ref component="extracellular_calcium_concentration"/>
<component_ref component="intracellular_calcium_concentration"/>
<component_ref component="reversal_potentials"/>
<component_ref component="fibroblast"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f2_gate"/>
<component_ref component="L_type_Ca_channel_f2ds_gate"/>
</component_ref>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_s_gate"/>
<component_ref component="transient_outward_current_r_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_potassium_current">
<component_ref component="rapid_delayed_rectifier_potassium_current_xr1_gate"/>
<component_ref component="rapid_delayed_rectifier_potassium_current_xr2_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_potassium_current">
<component_ref component="slow_delayed_rectifier_potassium_current_xs_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_activated_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="persistent_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="transient_outward_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_potassium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sarcoplasmic_reticulum_calcium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_translocation" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_release" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fibroblast" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_release" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="reversal_potentials"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L_Ca_cyt" variable_2="i_Ca_L_Ca_cyt"/>
<map_variables variable_1="i_Ca_L_Ca_ds" variable_2="i_Ca_L_Ca_ds"/>
<map_variables variable_1="i_Ca_L_Na_cyt" variable_2="i_Ca_L_Na_cyt"/>
<map_variables variable_1="i_Ca_L_Na_ds" variable_2="i_Ca_L_Na_ds"/>
<map_variables variable_1="i_Ca_L_K_cyt" variable_2="i_Ca_L_K_cyt"/>
<map_variables variable_1="i_Ca_L_K_ds" variable_2="i_Ca_L_K_ds"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="transient_outward_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_activated_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="persistent_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_p_Na" variable_2="i_p_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_b_Na" variable_2="i_b_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa_cyt" variable_2="i_NaCa_cyt"/>
<map_variables variable_1="i_NaCa_ds" variable_2="i_NaCa_ds"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fibroblast"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="sodium_background_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="persistent_sodium_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="time_independent_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_1="E_Ks" variable_2="E_Ks"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="sodium_activated_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="transient_outward_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="calcium_background_current"/>
<map_variables variable_1="E_Ca" variable_2="E_Ca"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="fast_sodium_current"/>
<map_variables variable_1="E_mh" variable_2="E_mh"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="extracellular_potassium_concentration"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="extracellular_sodium_concentration"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="extracellular_calcium_concentration"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_potassium_current" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="i_b_Na" variable_2="i_b_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="persistent_sodium_current" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="i_p_Na" variable_2="i_p_Na"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="i_Ca_L_Na_cyt" variable_2="i_Ca_L_Na_cyt"/>
<map_variables variable_1="i_Ca_L_Na_ds" variable_2="i_Ca_L_Na_ds"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="i_Ca_L_Ca_cyt" variable_2="i_Ca_L_Ca_cyt"/>
<map_variables variable_1="i_Ca_L_Ca_ds" variable_2="i_Ca_L_Ca_ds"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_ds" variable_2="Ca_ds"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="i_Ca_L_K_cyt" variable_2="i_Ca_L_K_cyt"/>
<map_variables variable_1="i_Ca_L_K_ds" variable_2="i_Ca_L_K_ds"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="extracellular_sodium_concentration"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="extracellular_calcium_concentration"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca"/>
</connection>
<connection>
<map_components component_1="sodium_activated_potassium_current" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="transient_outward_current" component_2="intracellular_potassium_concentration"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="i_NaCa_cyt" variable_2="i_NaCa_cyt"/>
<map_variables variable_1="i_NaCa_ds" variable_2="i_NaCa_ds"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_ds" variable_2="Ca_ds"/>
<map_variables variable_1="n_NaCa" variable_2="n_NaCa"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="i_NaCa_cyt" variable_2="i_NaCa_cyt"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="n_NaCa" variable_2="n_NaCa"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="extracellular_sodium_concentration"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="extracellular_calcium_concentration"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="sarcoplasmic_reticulum_calcium_pump" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="i_up" variable_2="i_up"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_up" variable_2="Ca_up"/>
</connection>
<connection>
<map_components component_1="calcium_translocation" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="i_trans" variable_2="i_trans"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
<map_variables variable_1="Ca_up" variable_2="Ca_up"/>
<map_variables variable_1="CaS_tot" variable_2="CaS_tot"/>
<map_variables variable_1="beta" variable_2="beta"/>
</connection>
<connection>
<map_components component_1="calcium_release" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="i_rel" variable_2="i_rel"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_ds" variable_2="Ca_ds"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="rapid_delayed_rectifier_potassium_current_xr1_gate"/>
<map_variables variable_1="xr1" variable_2="xr1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="rapid_delayed_rectifier_potassium_current_xr2_gate"/>
<map_variables variable_1="xr2" variable_2="xr2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_potassium_current" component_2="slow_delayed_rectifier_potassium_current_xs_gate"/>
<map_variables variable_1="xs" variable_2="xs"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f2_gate"/>
<map_variables variable_1="f2" variable_2="f2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Km_f2" variable_2="Km_f2"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f2ds_gate"/>
<map_variables variable_1="f2ds" variable_2="f2ds"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_ds" variable_2="Ca_ds"/>
<map_variables variable_1="Km_f2ds" variable_2="Km_f2ds"/>
<map_variables variable_1="R_decay" variable_2="R_decay"/>
</connection>
<connection>
<map_components component_1="transient_outward_current" component_2="transient_outward_current_s_gate"/>
<map_variables variable_1="s" variable_2="s"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="transient_outward_current" component_2="transient_outward_current_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="V_i" variable_2="V_i"/>
</connection>
<connection>
<map_components component_1="intracellular_potassium_concentration" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="V_i" variable_2="V_i"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="isotonic"/>
<map_variables variable_1="isotonic" variable_2="isotonic"/>
</connection>
<connection>
<map_components component_1="force" component_2="isotonic"/>
<map_variables variable_1="F_muscle" variable_2="F_muscle"/>
</connection>
<connection>
<map_components component_1="length" component_2="isotonic"/>
<map_variables variable_1="isotonic_mode" variable_2="isotonic_mode"/>
<map_variables variable_1="l" variable_2="l"/>
<map_variables variable_1="l_0" variable_2="l_0"/>
</connection>
<connection>
<map_components component_1="PE_velocity" component_2="isotonic"/>
<map_variables variable_1="isotonic_mode" variable_2="isotonic_mode"/>
</connection>
<connection>
<map_components component_1="CE_velocity" component_2="isotonic"/>
<map_variables variable_1="isotonic_mode" variable_2="isotonic_mode"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="isotonic"/>
<map_variables variable_1="stim_period" variable_2="stim_period"/>
</connection>
<connection>
<map_components component_1="environment" component_2="crossbridge_kinetics"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="length"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="CE_velocity"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="PE_velocity"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="parameters_izakov_et_al_1991"/>
<map_variables variable_1="v_max" variable_2="v_max"/>
</connection>
<connection>
<map_components component_1="force" component_2="parameters"/>
<map_variables variable_1="alpha_1" variable_2="alpha_1"/>
<map_variables variable_1="beta_1" variable_2="beta_1"/>
<map_variables variable_1="alpha_2" variable_2="alpha_2"/>
<map_variables variable_1="beta_2" variable_2="beta_2"/>
<map_variables variable_1="alpha_3" variable_2="alpha_3"/>
<map_variables variable_1="beta_3" variable_2="beta_3"/>
<map_variables variable_1="lambda" variable_2="lambda"/>
</connection>
<connection>
<map_components component_1="force" component_2="crossbridge_kinetics"/>
<map_variables variable_1="N" variable_2="N"/>
</connection>
<connection>
<map_components component_1="force" component_2="length"/>
<map_variables variable_1="l_1" variable_2="l_1"/>
<map_variables variable_1="l_2" variable_2="l_2"/>
<map_variables variable_1="l_3" variable_2="l_3"/>
</connection>
<connection>
<map_components component_1="force" component_2="CE_velocity"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="k_P_vis" variable_2="k_P_vis"/>
</connection>
<connection>
<map_components component_1="force" component_2="PE_velocity"/>
<map_variables variable_1="w" variable_2="w"/>
<map_variables variable_1="k_S_vis" variable_2="k_S_vis"/>
</connection>
<connection>
<map_components component_1="force" component_2="average_crossbridge_force"/>
<map_variables variable_1="p_v" variable_2="p_v"/>
</connection>
<connection>
<map_components component_1="crossbridge_kinetics" component_2="parameters"/>
<map_variables variable_1="mu" variable_2="mu"/>
<map_variables variable_1="k_mu" variable_2="k_mu"/>
<map_variables variable_1="kappa" variable_2="kappa"/>
<map_variables variable_1="kappa_0" variable_2="kappa_0"/>
<map_variables variable_1="m_0" variable_2="m_0"/>
</connection>
<connection>
<map_components component_1="crossbridge_kinetics" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="A" variable_2="A"/>
<map_variables variable_1="A_tot" variable_2="A_tot"/>
<map_variables variable_1="N" variable_2="N"/>
<map_variables variable_1="L_oz" variable_2="L_oz"/>
</connection>
<connection>
<map_components component_1="crossbridge_kinetics" component_2="average_crossbridge_force"/>
<map_variables variable_1="G_star" variable_2="G_star"/>
<map_variables variable_1="P_star" variable_2="P_star"/>
</connection>
<connection>
<map_components component_1="crossbridge_kinetics" component_2="length"/>
<map_variables variable_1="l_1" variable_2="l_1"/>
</connection>
<connection>
<map_components component_1="crossbridge_kinetics" component_2="CE_velocity"/>
<map_variables variable_1="K_kappa" variable_2="K_kappa"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="N" variable_2="N"/>
</connection>
<connection>
<map_components component_1="crossbridge_kinetics" component_2="parameters_izakov_et_al_1991"/>
<map_variables variable_1="S_0" variable_2="S_0"/>
<map_variables variable_1="q_v" variable_2="q_v"/>
<map_variables variable_1="v_st" variable_2="v_st"/>
<map_variables variable_1="q_4" variable_2="q_4"/>
</connection>
<connection>
<map_components component_1="length" component_2="CE_velocity"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="phi_chi_2" variable_2="phi_chi_2"/>
<map_variables variable_1="dl_1_dt" variable_2="dl_1_dt"/>
<map_variables variable_1="l_1" variable_2="l_1"/>
<map_variables variable_1="l_2" variable_2="l_2"/>
<map_variables variable_1="l_3" variable_2="l_3"/>
</connection>
<connection>
<map_components component_1="length" component_2="PE_velocity"/>
<map_variables variable_1="w" variable_2="w"/>
<map_variables variable_1="k_S_vis" variable_2="k_S_vis"/>
<map_variables variable_1="dl_1_dt" variable_2="dl_1_dt"/>
<map_variables variable_1="l_1" variable_2="l_1"/>
<map_variables variable_1="dl_2_dt" variable_2="dl_2_dt"/>
<map_variables variable_1="l_2" variable_2="l_2"/>
<map_variables variable_1="l_3" variable_2="l_3"/>
</connection>
<connection>
<map_components component_1="length" component_2="membrane"/>
<map_variables variable_1="stim_start" variable_2="stim_start"/>
<map_variables variable_1="stim_end" variable_2="stim_end"/>
<map_variables variable_1="stim_period" variable_2="stim_period"/>
<map_variables variable_1="stim_duration" variable_2="stim_duration"/>
<map_variables variable_1="stim_amplitude" variable_2="stim_amplitude"/>
</connection>
<connection>
<map_components component_1="CE_velocity" component_2="parameters"/>
<map_variables variable_1="alpha_1" variable_2="alpha_1"/>
<map_variables variable_1="beta_1" variable_2="beta_1"/>
<map_variables variable_1="alpha_2" variable_2="alpha_2"/>
<map_variables variable_1="beta_2" variable_2="beta_2"/>
<map_variables variable_1="alpha_3" variable_2="alpha_3"/>
<map_variables variable_1="beta_3" variable_2="beta_3"/>
<map_variables variable_1="lambda" variable_2="lambda"/>
</connection>
<connection>
<map_components component_1="CE_velocity" component_2="parameters_izakov_et_al_1991"/>
<map_variables variable_1="v" variable_2="v"/>
</connection>
<connection>
<map_components component_1="CE_velocity" component_2="PE_velocity"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="w" variable_2="w"/>
<map_variables variable_1="k_S_vis" variable_2="k_S_vis"/>
<map_variables variable_1="phi_chi" variable_2="phi_chi"/>
</connection>
<connection>
<map_components component_1="PE_velocity" component_2="parameters"/>
<map_variables variable_1="alpha_1" variable_2="alpha_1"/>
<map_variables variable_1="beta_1" variable_2="beta_1"/>
<map_variables variable_1="alpha_2" variable_2="alpha_2"/>
<map_variables variable_1="beta_2" variable_2="beta_2"/>
<map_variables variable_1="alpha_3" variable_2="alpha_3"/>
<map_variables variable_1="beta_3" variable_2="beta_3"/>
<map_variables variable_1="lambda" variable_2="lambda"/>
</connection>
<connection>
<map_components component_1="average_crossbridge_force" component_2="parameters"/>
<map_variables variable_1="v_max" variable_2="v_max"/>
<map_variables variable_1="a" variable_2="a"/>
<map_variables variable_1="d_h" variable_2="d_h"/>
<map_variables variable_1="alpha_P" variable_2="alpha_P"/>
</connection>
<connection>
<map_components component_1="average_crossbridge_force" component_2="parameters_izakov_et_al_1991"/>
<map_variables variable_1="v_1" variable_2="v_1"/>
<map_variables variable_1="alpha_G" variable_2="alpha_G"/>
</connection>
<connection>
<map_components component_1="average_crossbridge_force" component_2="CE_velocity"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="phi_chi" variable_2="phi_chi"/>
<map_variables variable_1="p_v" variable_2="p_v"/>
<map_variables variable_1="p_prime_v" variable_2="p_prime_v"/>
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="parameters_izakov_et_al_1991"/>
<map_variables variable_1="k_A" variable_2="k_A"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="time_independent_potassium_current"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="transient_outward_current"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="sodium_potassium_pump"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="L_type_Ca_channel"/>
<map_variables variable_1="i_Ca_L_K_ds" variable_2="i_Ca_L_K_ds"/>
<map_variables variable_1="i_Ca_L_K_cyt" variable_2="i_Ca_L_K_cyt"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="membrane"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="n_NaK" variable_2="n_NaK"/>
</connection>
<connection>
<map_components component_1="intracellular_potassium_concentration" component_2="intracellular_sodium_concentration"/>
<map_variables variable_1="n_NaK" variable_2="n_NaK"/>
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="V_e" variable_2="V_e"/>
</connection>
</model>
