BG_KACh.cellml
About
Landing page for the muscarinic potassium channel (K-ACh).
Other names include: G protein-coupled inwardly rectifying potassium channel (GIRK)
This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is activated through muscarinic receptors that are in turn activated by acetylcholine (ACh). K-ACh is part of the inward rectifying (K-ir) family.
These channels are heterotetramers composed of two GIRK1 and two GIRK4 subunits.
Models
The below image shows the bond graph diagram of the channel operating under normal physiological conditions.
Protein knowledge
Subfamilies
The following list contains the constituents of K-ACh.
| Channel name | Alias | Gene | Structure |
|---|---|---|---|
| KCNJ3 | GIRK1/Kir3.1 | Uniprot 1 | SMR 1 |
| KCNJ5 | GIRK4/Kir3.4 | Uniprot 4 | SMR 4 |
Literature
| Title | Author |
|---|---|
| Activation of the atrial KACh channel by the βγ subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates | Liang Sui et al. |
Existing models
| Title | Author |
|---|---|
| BG_K_ACh | S Fong |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.
Other annotations
| Item | Database |
|---|---|
| I(KACh) inward rectifier potassium channel complex | Gene Ontology |