<?xml version='1.0' encoding='UTF-8'?>
<!-- PLB module,
5 Aug 21 - not containing Inhib1 reactions (this is a separate module)
Use [Ip] where [Ip] = [Ip] + [Ip_S2]
Use [PKACI] where [PKACI] = [PKACI] + [PKACI_S2]-->
<model name="BG_PLB" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="fmol" units_ref="fmol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="mM" units_ref="mM"/>
<units name="uM" units_ref="uM"/>
<units name="mM_per_sec" units_ref="mM_per_sec"/>
<units name="uM_per_sec" units_ref="uM_per_sec"/>
<units name="pL" units_ref="pL"/>
<units name="m_to_u" units_ref="m_to_u"/>
</import>
<import xlink:href="units_and_constants/constants_BG.cellml">
<component component_ref="constants" name="constants"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<variable initial_value="4.028E+00" name="q_PLB" public_interface="out" units="fmol"/>
<variable initial_value="1.117E-03" name="q_PKACI" public_interface="out" units="fmol"/>
<variable initial_value="1e-13" name="q_PLB_PKACI" public_interface="out" units="fmol"/>
<variable initial_value="3.382E-02" name="q_PP1" public_interface="out" units="fmol"/>
<variable initial_value="1e-13" name="q_PLBp_PP1" public_interface="out" units="fmol"/>
<variable initial_value="1.560E-01" name="q_PLBp" public_interface="out" units="fmol"/>
<variable initial_value="9.994E-04" name="q_Ip" public_interface="out" units="fmol"/>
<variable initial_value="1e-13" name="q_Ip_PP1" public_interface="out" units="fmol"/>
<!-- From submodule-->
<variable name="v_PLBph1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_PLBph2" public_interface="in" units="fmol_per_sec"/>
<variable name="v_PLBd1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_PLBd2" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Inh" public_interface="in" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLB</ci>
</apply>
<apply>
<minus/>
<ci>v_PLBd2</ci>
<ci>v_PLBph1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PKACI</ci>
</apply>
<apply>
<minus/>
<ci>v_PLBph2</ci>
<ci>v_PLBph1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLB_PKACI</ci>
</apply>
<apply>
<minus/>
<ci>v_PLBph1</ci>
<ci>v_PLBph2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PP1</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_PLBd2</ci>
<ci>v_PLBd1</ci>
</apply>
<ci>v_Inh</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLBp_PP1</ci>
</apply>
<apply>
<minus/>
<ci>v_PLBd1</ci>
<ci>v_PLBd2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLBp</ci>
</apply>
<apply>
<minus/>
<ci>v_PLBph2</ci>
<ci>v_PLBd1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ip</ci>
</apply>
<apply>
<minus/>
<ci>v_Inh</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ip_PP1</ci>
</apply>
<ci>v_Inh</ci>
</apply>
</math>
</component>
<component name="PLB_parameters">
<variable initial_value="45.5263" name="kappa_PLBph1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.55904" name="kappa_PLBph2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.386674" name="kappa_PLBd1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.21269" name="kappa_PLBd2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="431.435" name="kappa_Inh" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00235741" name="K_PLB" public_interface="out" units="per_fmol"/>
<variable initial_value="0.395191" name="K_PKACI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.638527" name="K_PLB_PKACI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.361989" name="K_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.203757" name="K_PLBp_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.326014" name="K_PLBp" public_interface="out" units="per_fmol"/>
<variable initial_value="5.41093" name="K_Ip" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0673793" name="K_Ip_PP1" public_interface="out" units="per_fmol"/>
</component>
<component name="PLB">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<!-- PLB parameters-->
<variable name="kappa_PLBph1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_PLBph2" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_PLBd1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_PLBd2" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Inh" public_interface="in" units="fmol_per_sec"/>
<variable name="K_PLB" public_interface="in" units="per_fmol"/>
<variable name="K_PKACI" public_interface="in" units="per_fmol"/>
<variable name="K_PLB_PKACI" public_interface="in" units="per_fmol"/>
<variable name="K_PP1" public_interface="in" units="per_fmol"/>
<variable name="K_PLBp_PP1" public_interface="in" units="per_fmol"/>
<variable name="K_PLBp" public_interface="in" units="per_fmol"/>
<variable name="K_Ip" public_interface="in" units="per_fmol"/>
<variable name="K_Ip_PP1" public_interface="in" units="per_fmol"/>
<variable name="v_PLBph1" public_interface="out" units="fmol_per_sec"/>
<variable name="v_PLBph2" public_interface="out" units="fmol_per_sec"/>
<variable name="v_PLBd1" public_interface="out" units="fmol_per_sec"/>
<variable name="v_PLBd2" public_interface="out" units="fmol_per_sec"/>
<variable name="v_Inh" public_interface="out" units="fmol_per_sec"/>
<variable name="mu_PLB" units="J_per_mol"/>
<variable name="mu_PKACI" units="J_per_mol"/>
<variable name="mu_PLB_PKACI" units="J_per_mol"/>
<variable name="mu_PP1" units="J_per_mol"/>
<variable name="mu_PLBp_PP1" units="J_per_mol"/>
<variable name="mu_PLBp" units="J_per_mol"/>
<variable name="mu_Ip" units="J_per_mol"/>
<variable name="mu_Ip_PP1" units="J_per_mol"/>
<!-- Input from global environment-->
<variable name="q_PLB" public_interface="in" units="fmol"/>
<variable name="q_PKACI" public_interface="in" units="fmol"/>
<variable name="q_PLB_PKACI" public_interface="in" units="fmol"/>
<variable name="q_PP1" public_interface="in" units="fmol"/>
<variable name="q_PLBp_PP1" public_interface="in" units="fmol"/>
<variable name="q_PLBp" public_interface="in" units="fmol"/>
<variable name="q_Ip" public_interface="in" units="fmol"/>
<variable name="q_Ip_PP1" public_interface="in" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_PLB</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLB</ci>
<ci>q_PLB</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PKACI</ci>
<ci>q_PKACI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PLB_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLB_PKACI</ci>
<ci>q_PLB_PKACI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PP1</ci>
<ci>q_PP1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PLBp_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLBp_PP1</ci>
<ci>q_PLBp_PP1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PLBp</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLBp</ci>
<ci>q_PLBp</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ip</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ip</ci>
<ci>q_Ip</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ip_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ip_PP1</ci>
<ci>q_Ip_PP1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_PLBph1</ci>
<apply>
<times/>
<ci>kappa_PLBph1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLB</ci>
<ci>mu_PKACI</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLB_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_PLBph2</ci>
<apply>
<times/>
<ci>kappa_PLBph2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLB_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLBp</ci>
<ci>mu_PKACI</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_PLBd1</ci>
<apply>
<times/>
<ci>kappa_PLBd1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLBp</ci>
<ci>mu_PP1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLBp_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_PLBd2</ci>
<apply>
<times/>
<ci>kappa_PLBd2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLBp_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLB</ci>
<ci>mu_PP1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Inh</ci>
<apply>
<times/>
<ci>kappa_Inh</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PP1</ci>
<ci>mu_Ip</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_Ip_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="PLB"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_PLB" variable_2="q_PLB"/>
<map_variables variable_1="q_PKACI" variable_2="q_PKACI"/>
<map_variables variable_1="q_PLB_PKACI" variable_2="q_PLB_PKACI"/>
<map_variables variable_1="q_PP1" variable_2="q_PP1"/>
<map_variables variable_1="q_PLBp_PP1" variable_2="q_PLBp_PP1"/>
<map_variables variable_1="q_PLBp" variable_2="q_PLBp"/>
<map_variables variable_1="q_Ip" variable_2="q_Ip"/>
<map_variables variable_1="q_Ip_PP1" variable_2="q_Ip_PP1"/>
<map_variables variable_1="v_PLBph1" variable_2="v_PLBph1"/>
<map_variables variable_1="v_PLBph2" variable_2="v_PLBph2"/>
<map_variables variable_1="v_PLBd1" variable_2="v_PLBd1"/>
<map_variables variable_1="v_PLBd2" variable_2="v_PLBd2"/>
<map_variables variable_1="v_Inh" variable_2="v_Inh"/>
</connection>
<connection>
<map_components component_1="PLB_parameters" component_2="PLB"/>
<map_variables variable_1="kappa_PLBph1" variable_2="kappa_PLBph1"/>
<map_variables variable_1="kappa_PLBph2" variable_2="kappa_PLBph2"/>
<map_variables variable_1="kappa_PLBd1" variable_2="kappa_PLBd1"/>
<map_variables variable_1="kappa_PLBd2" variable_2="kappa_PLBd2"/>
<map_variables variable_1="kappa_Inh" variable_2="kappa_Inh"/>
<map_variables variable_1="K_PLB" variable_2="K_PLB"/>
<map_variables variable_1="K_PKACI" variable_2="K_PKACI"/>
<map_variables variable_1="K_PLB_PKACI" variable_2="K_PLB_PKACI"/>
<map_variables variable_1="K_PP1" variable_2="K_PP1"/>
<map_variables variable_1="K_PLBp_PP1" variable_2="K_PLBp_PP1"/>
<map_variables variable_1="K_PLBp" variable_2="K_PLBp"/>
<map_variables variable_1="K_Ip" variable_2="K_Ip"/>
<map_variables variable_1="K_Ip_PP1" variable_2="K_Ip_PP1"/>
</connection>
<connection>
<map_components component_1="constants" component_2="PLB"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#model">
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Bag xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">protein-modules</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
</model>
