Model Mathematics

Component: environment

Component: intracellular_ion_concentrations

mtime=time-167⁢⌊time167⌋1 Ca_i=1⁢1.8535847759 e -5⁢mtime3+-0.001590341066858⁢mtime2+0.043645898640826⁢mtime1+0.167079436392938ifmtime≥1.17∧mtime<30.841⁢-5.7458491 e -8⁢mtime3+3.1122215647 e -5⁢mtime2-0.006618494920814⁢mtime1+0.720441888689583ifmtime≥30.840.216otherwise

Component: crossbridges

permtot=TRPNperm50nperm ddtimexb=k_xb⁢permtot⁢1-xb-1permtot⁢xb

Component: troponin

Ca_50=Ca_50ref⁢1+beta_1⁢lambda_m-1 ddtimeTRPN=k_off⁢Ca_iCa_50n_TRPN⁢1-TRPN-TRPN

Component: Myofilaments

lambda=1 dlambdadt=0

Component: filament_overlap

lambda_m=1.2iflambda>1.2lambdaotherwise lambda_s=0.87iflambda_m<0.87lambda_motherwise overlap=1+beta_0⁢lambda_m+lambda_s-1.87

Component: isometric_tension

T_0=T_ref⁢xb⁢overlap

Component: dynamic_stiffness

Q=Q_1+Q_2 Tension=T_0⁢a⁢Q+11-QifQ<0T_0⁢1+a+2⁢Q1+Qotherwise ddtimeQ_1=A_1⁢dlambdadt-alpha_1⁢Q_1 ddtimeQ_2=A_2⁢dlambdadt-alpha_2⁢Q_2