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Model Mathematics

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Component: environment

Component: cortisol

\frac{d}{d time} (cortisol) = k1 ACTH + k2 - (k3 cortisol)

Component: ACTH

\frac{d}{d time} (ACTH) = k4 CRH + k5 - (k6 ACTH + (k4 CRH + k5) \frac{Imax cortisol}{Kd + cortisol})

Component: CRH

\frac{d}{d time} (CRH) = pulse + k7 - (k8 CRH)

Source: Derived from workspace Gonzalezheydrich, Steingard, Kohane, 1994 at changeset 0c5151d49a66.

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A computer simulation of the hypothalamic-pituitary-adrenal axis