You are here: Home / Exposures / Fallon, Lauffenburger, 2000 / Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response

Model Mathematics

Component based math viewer is available

Component: environment

Component: Rs

\frac{d}{d time} (Rs) = (kr + ksyn) Cs + Vs - (kf L Rs + kt Rs)

Component: Cs

\frac{d}{d time} (Cs) = kf L Rs - ((kr + ke) Cs)

Component: Ri

\frac{d}{d time} (Ri) = kre Ci + kt Rs - (kfe Li Ri + kh Ri)

Component: Ci

\frac{d}{d time} (Ci) = kfe Li Ri + ke Cs - ((kre + kh) Ci)

Component: Li

\frac{d}{d time} (Li) = \frac{kre Ci - (kfe Li Ri)}{Ve NA} - (kx Li)

Component: Ld

\frac{d}{d time} (Ld) = kh Ci

Component: L

\frac{d}{d time} (L) = \frac{(kr Cs + kx Li Ve NA - (kf L Rs)) Y}{NA}

Component: Y

\frac{d}{d time} (Y) = max {\frac{600.0 Cs}{250.0 + Cs} - 200.0} 1E3

Component: model_parameters

Source: Derived from workspace Fallon, Lauffenburger, 2000 at changeset 25e5b762199c.; This exposure was expired. A more up-to-date exposure is available, or view related resources.

Collaboration: To begin collaborating on this work, please use your git client and issue this command:

Downloads

Views Available

Tools

License: This work is licensed under a Creative Commons Attribution 3.0 Unported License.

Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response