Model Mathematics

\frac{d}{d time} (MPF_n) = (k_in MPF_c - (k_out MPF_n) - ((k_dn_+ k_dn__FZY) MPF_n) - ((k_wee_+ k_wee__Wee1_n) MPF_n)) + (k_stg_+ k_stg__StgP_n) preMPF_n

\frac{d}{d time} (preMPF_n) = (k_in preMPF_c - (k_out preMPF_n) - ((k_dn_+ k_dn__FZY) preMPF_n)) + (k_wee_+ k_wee__Wee1_n) MPF_n - ((k_stg_+ k_stg__StgP_n) preMPF_n)

\frac{d}{d time} (MPF_c) = (k_sc - (\frac{epsilon N (k_in MPF_c - (k_out MPF_n))}{1 - (N epsilon)}) - (k_dc_MPF_c)) + (k_stg_+ k_stg__StgP_c) preMPF_c - ((k_wee_+ k_wee__Wee1_c) MPF_c)

\frac{d}{d time} (preMPF_c) = (\frac{(- epsilon) N (k_in preMPF_c - (k_out preMPF_n))}{1 - (N epsilon)} - (k_dc_preMPF_c) - ((k_stg_+ k_stg__StgP_c) preMPF_c)) + (k_wee_+ k_wee__Wee1_c) MPF_c

\frac{d}{d time} (IE) = \frac{k_aie (1 - IE) MPF_n}{j_aie + 1 - IE} - (\frac{k_iie IE}{j_iie + IE})

\frac{d}{d time} (FZY) = \frac{k_afz IE (1 - FZY)}{j_afz + 1 - FZY} - (\frac{k_ifz FZY}{j_ifz + FZY})

\frac{d}{d time} (Stg_m) = (- (\frac{k_dm_}{j_m + Stg_m} + k_dm__Xp)) Stg_m

\frac{d}{d time} (Xm) = k_sxm N

\frac{d}{d time} (Xp) = k_sxp Xm

\frac{d}{d time} (StgP_n) = (k_ins StgP_c - (k_outs StgP_n)) + \frac{(k_astg_+ k_astg__MPF_n) Stg_n}{j_astg + Stg_n} - (\frac{k_istg StgP_n}{j_istg + StgP_n}) - (k_dstg StgP_n)

\frac{d}{d time} (Stg_n) = (k_ins Stg_c - (k_outs Stg_n) - (\frac{(k_astg_+ k_astg__MPF_n) Stg_n}{j_astg + Stg_n})) + \frac{k_istg StgP_n}{j_istg + StgP_n} - (k_dstg Stg_n)

\frac{d}{d time} (StgP_c) = ((- k_dstg) StgP_c - (\frac{epsilon N (k_ins StgP_c - (k_outs StgP_n))}{1 - (N epsilon)})) + \frac{(k_astg_+ k_astg__MPF_c) Stg_c}{j_astg + Stg_c} - (\frac{k_istg StgP_c}{j_istg + StgP_c})

\frac{d}{d time} (Stg_c) = (k_sstg Stg_m - (k_dstg Stg_c) - (\frac{epsilon N (k_ins Stg_c - (k_outs Stg_n))}{1 - (N epsilon)}) - (\frac{(k_astg_+ k_astg__MPF_c) Stg_c}{j_astg + Stg_c})) + \frac{k_istg StgP_c}{j_istg + StgP_c}

\frac{d}{d time} (Wee1_n) = (k_inw Wee1_c - (k_outw Wee1_n)) + \frac{k_awee Wee1P_n}{j_awee + Wee1P_n} - (\frac{(k_iwee_+ k_iwee__MPF_n) Wee1_n}{j_iwee + Wee1_n})

\frac{d}{d time} (Wee1_c) = \frac{(- (k_inw Wee1_c - (k_outw Wee1_n))) N epsilon}{1 - (N epsilon)} + \frac{k_awee Wee1P_c}{j_awee + Wee1P_c} - (\frac{(k_iwee_+ k_iwee__MPF_c) Wee1_c}{j_iwee + Wee1_c})

\frac{d}{d time} (Wee1P_n) = (k_inw Wee1P_c - (k_outw Wee1P_n) - (\frac{k_awee Wee1P_n}{j_awee + Wee1P_n})) + \frac{(k_iwee_+ k_iwee__MPF_n) Wee1_n}{j_iwee + Wee1_n}

Wee1P_c = \frac{Wee1_T - (N epsilon (Wee1_n + Wee1P_n))}{1 - (N epsilon)} - Wee1_c

\frac{d}{d time} (N) = 0

CycB_T = (1 - (N epsilon)) (MPF_c + preMPF_c) + N epsilon (MPF_n + preMPF_n)

Stg_T = (1 - (N epsilon)) (Stg_c + StgP_c) + N epsilon (Stg_n + StgP_n)

StgP_T = (1 - (N epsilon)) StgP_c + N epsilon StgP_n