You are here: Home / Exposures / Martinov, Vitvitsky, Mosharov, Banerjee, Ataullakhanov, 2000 / A Substrate Switch: A New Mode of Regulation in the Methionine Metabolic Pathway

Model Mathematics

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Component: environment

Component: Ado

Component: Met

Component: Hcy

Hcy = AdoHcy \frac{K_AHC}{Ado}

Component: K_AHC

K_AHC = \frac{Ado Hcy}{AdoHcy}

Component: AdoMet

\frac{d}{d time} (AdoMet) = V_MATI + V_MATIII - (V_MET + V_GNMT)

Component: AdoHcy

\frac{d}{d time} (AdoHcy) = \frac{V_MET + V_GNMT - V_D}{1.0 + \frac{K_AHC}{Ado}}

Component: V_MATI

V_MATI = \frac{V_MATImax}{1.0 + \frac{Km_MATI}{Met} (1.0 + \frac{AdoMet}{Ki_MATI})}

Component: V_MATIII

V_MATIII = \frac{V_MATIIImax}{1.0 + \frac{Km1_MATIII Km2_MATIII}{{Met}^{2.0} + Met Km2_MATIII}} Km1_MATIII = \frac{20000.0}{1.0 + 5.7 {(\frac{AdoMet}{AdoMet + 600.0})}^{2.0}}

Component: V_MET

V_MET = \frac{V_METmax}{1.0 + \frac{Km1_MET}{AdoMet} + Km2_MET_A + Km2_MET_A \frac{Km1_MET}{AdoMet}} Km1_MET = 10.0 (1.0 + \frac{AdoHcy}{4.0})

Component: V_GNMT

V_GNMT = \frac{V_GNMTmax}{1.0 + {(\frac{Km_GNMT}{AdoMet})}^{2.3}} \frac{1.0}{1.0 + \frac{AdoHcy}{Ki_GNMT}}

Component: V_D

V_D = alphad Hcy

Source: Derived from workspace Martinov, Vitvitsky, Mosharov, Banerjee, Ataullakhanov, 2000 at changeset e7ea96fe0285.; This exposure was expired. A more up-to-date exposure is available, or view related resources.

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A Substrate Switch: A New Mode of Regulation in the Methionine Metabolic Pathway