Model Mathematics

Component: environment

Component: geometry

Component: NFAT_Cycling_interface

nuclearNFAT=NFATN_n+NFATp_n

Component: calcium

timeInStim_modTrainPeriod=t-ttrainPeriodtrainPeriod timeInStim_modPulsePeriod=t-t0.10.1 Ca=1000timeInStim_modTrainPeriod-5-9.884615385+290.6923077iftimeInStim_modTrainPeriod5timeInStim_modTrainPeriod5.02t<stimEnd1000timeInStim_modPulsePeriod51.89423077+290.6923077iftimeInStim_modTrainPeriod<5timeInStim_modPulsePeriod0.016t<stimEnd1000timeInStim_modPulsePeriod-0.016-9.884615385+1121iftimeInStim_modTrainPeriod<5timeInStim_modPulsePeriod>0.016t<stimEnd93otherwise

Component: calcineurin

act_N=CanCan+K_mNn1+K_dNM act_Napp=act_Nift<tNinhibact_N-t-tNinhibtau_actNifttNinhib

Component: NFAT_Cycling

J1=k_f1NFATp_cNtotact_N-k_r1NFATN_c1-act_N J2=k_f2NFATN_c J3=k_f3NFATN_n1-act_N-k_r3NFATp_nNtotact_N J4=k_f4NFATp_n ddtNFATp_c=J4Ccn-J1 ddtNFATN_c=J1-J2 ddtNFATN_n=J2Ccn-J3 ddtNFATp_n=J3-J4