Rendering of the source text

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<!--
This CellML file was generated on 18/04/2008 at 09:15:12 using:

COR (0.9.31.915)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
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<article>
  <articleinfo>
  <title>Modelling the Roles of Individual Current Systems in Ventricular Cells and in the SA Node</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model has been curated and unit checked by Alan Garny in collaboration with the model authors and it is known to run in COR to reproduce the published results.  It also works in JSim as long as the stimulus protocol is altered. 
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
Different types of ion channel, with their distinct gating and conductance properties, play a unique role in generating membrane excitation.  Although the behaviours of single ion channels have been extensively studied experimentally, ionic current interactions make it difficult to deduce their individual roles in membrane excitability.  In order to better understand the roles of the individual ion currents, Satoshi Matsuoka <emphasis>et al.</emphasis> have developed a mathematical model of membrane excitation for the ventricular cell. 
</para>

<para>
The Matsuoka <emphasis>et al.</emphasis> mathematical model is a development of previously published cardiac cellular models.  The group's general approach to modelling was based on the methods used in the Difrancesco-Noble, 1985 Model and the Luo-Rudy Ventricular Model II (dynamic), 1994.  In addition, the compound <emphasis>Kyoto Model</emphasis> of Matsuoka <emphasis>et al.</emphasis> incorporates the Negroni and Lascano (1996) model of cardiac muscle contraction, allowing simulation of sarcomere shortening, and also, the gating model of Shirokov <emphasis>et al.</emphasis> is used for both the fast Na<superscript>+</superscript> and L-type Ca<superscript>2+</superscript> channels.   
</para>

<para>
New experimental data are included, such as new kinetics of the inward rectifier K<superscript>+</superscript> channel, the delayed rectifier K<superscript>+</superscript> channel, and the sustained inward current (for more details on the reaction kinetics, see figure 3 below).  Model simulations showed that ion conductance by the L-type Ca<superscript>2+</superscript> channel (I<subscript>CaL</subscript>) dominates the membrane conductance during the action potential.  Repolarisation occurs as the following currents are sequentially activated: I<subscript>Ks</subscript>; I<subscript>Kr</subscript>; and I<subscript>K1</subscript>.  Agreement between model simulation results and experimental data was taken as supporting evidence for the validity of the model. 
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
Role of Individual Ionic Current Systems in Ventricular Cells Hypothesized by a Model Study, Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A, 2003, <emphasis>The Japanese Journal of Physiology</emphasis>, 53, 105-123. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12877767&amp;dopt=Abstract">PubMed ID: 12877767</ulink>
</para>

<informalfigure float="0" id="fig_ventricular_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>ventricular cell diagram</title>
    </objectinfo>
    <imagedata fileref="matsuoka_2003.png"/>
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<caption>A schematic diagram describing the ionic components of the Matsuoka <emphasis>et al.</emphasis> 2003 ventricular cell mathematical model.  Ions are exchanged between the intracellular and extracellular environments, and between the cytosol and the sarcoplasmic reticulum (SR) via channels and pumps.  Unique to the ventricular cells are the transient outward current, I<subscript>to</subscript>, and the slow component of the delayed rectifier K<superscript>+</superscript> current, I<subscript>Ks</subscript>.</caption>
</informalfigure>

<informalfigure float="0" id="fig_reaction_kinetics">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>reaction kinetics diagram</title>
    </objectinfo>
    <imagedata fileref="matsuoka_3_2003.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram describing the reaction kinetics of the ion channel gates in the Matsuoka <emphasis>et al.</emphasis> 2003 mathematical models.  A) The kinetics of the sodium channel voltage-dependent gate.  B) The kinetics of the Na-Ca exchange pump.  C) The kinetics of the Na-K pump.  D) The kinetics of the inward rectifier K<superscript>+</superscript> current.  E)  The kinetics of the Ca<superscript>2+</superscript>-dependent gate of the L-type Ca<superscript>2+</superscript> channel.  F) The kinetics of the ultra-slow gates of several ion channels.  G) The kinetics of the SR Ca<superscript>2+</superscript> pump.  H) The kinetics of the hyperpolarisation-activated cation current.  I) The kinetics of the RyR channel in the SR.</caption>
</informalfigure>

</sect1>
</article>
</documentation>

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      <variable name="CF_Na" public_interface="out" units="millimolar"/>
      <variable name="CF_Ca" public_interface="out" units="millimolar"/>
      <variable name="CF_K" public_interface="out" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>CF_Na</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <ci>Nao</ci>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Vm</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>F</ci>
                              <ci>Vm</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <ci>Nai</ci>
                           <apply>
                              <times/>
                              <ci>Nao</ci>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <ci>F</ci>
                                       </apply>
                                       <ci>Vm</ci>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <ci>R</ci>
                                       <ci>T</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>F</ci>
                                 </apply>
                                 <ci>Vm</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>CF_Ca</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <ci>Cao</ci>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Vm</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>F</ci>
                              <ci>Vm</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <ci>Cai</ci>
                           <apply>
                              <times/>
                              <ci>Cao</ci>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                       </apply>
                                       <ci>F</ci>
                                       <ci>Vm</ci>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <ci>R</ci>
                                       <ci>T</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <ci>F</ci>
                                 <ci>Vm</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>CF_K</ci>
            <piecewise>
               <piece>
                  <ci>Ki</ci>
                  <apply>
                     <eq/>
                     <ci>Vm</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>F</ci>
                              <ci>Vm</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <ci>Ki</ci>
                           <apply>
                              <times/>
                              <ci>Ko</ci>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <ci>F</ci>
                                       </apply>
                                       <ci>Vm</ci>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <ci>R</ci>
                                       <ci>T</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>F</ci>
                                 </apply>
                                 <ci>Vm</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="ATP_production">
      <variable initial_value="4.657102729020499" name="ATPi" public_interface="out" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="dATPdt_NL" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Vi" public_interface="in" units="micrometre3"/>
      <variable name="i_NaK" public_interface="in" units="picoA"/>
      <variable name="i_SR_U" public_interface="in" units="picoA"/>
      <variable initial_value="0.003" name="ProducingRate_Max" units="per_millisecond"/>
      <variable initial_value="5" name="Adenosine_Total" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ATPi</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>ProducingRate_Max</ci>
                        <apply>
                           <minus/>
                           <ci>Adenosine_Total</ci>
                           <ci>ATPi</ci>
                        </apply>
                     </apply>
                     <ci>dATPdt_NL</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>i_NaK</ci>
                     <apply>
                        <times/>
                        <ci>F</ci>
                        <ci>Vi</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>i_SR_U</ci>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>F</ci>
                     <ci>Vi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_current">
      <variable cmeta:id="sodium_current_i_Na" name="i_Na" public_interface="out" units="picoA"/>
      <variable name="i_Na_Na" public_interface="out" units="picoA"/>
      <variable name="i_Na_K" public_interface="out" units="picoA"/>
      <variable initial_value="2860" name="P_Na" units="picoA_per_millimolar"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="CF_Na" public_interface="in" units="millimolar"/>
      <variable name="CF_K" public_interface="in" units="millimolar"/>
      <variable name="p_AP_Na" private_interface="in" units="dimensionless"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <plus/>
               <ci>i_Na_Na</ci>
               <ci>i_Na_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Na_Na</ci>
            <apply>
               <times/>
               <ci>P_Na</ci>
               <ci>CF_Na</ci>
               <ci>p_AP_Na</ci>
               <ci>y</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Na_K</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
               <ci>P_Na</ci>
               <ci>CF_K</ci>
               <ci>p_AP_Na</ci>
               <ci>y</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_current_voltage_dependent_gate">
      <variable initial_value="1.779648367445368e-5" name="p_AP_Na" public_interface="out" units="dimensionless"/>
      <variable name="p_RI_Na" units="dimensionless"/>
      <variable initial_value="0.3556412697995689" name="p_RP_Na" units="dimensionless"/>
      <variable initial_value="0.40285968661346977" name="p_AI_Na" units="dimensionless"/>
      <variable name="k_RP_AP" units="per_millisecond"/>
      <variable name="k_AP_RP" units="per_millisecond"/>
      <variable name="k_RI_AI" units="per_millisecond"/>
      <variable name="k_AI_RI" units="per_millisecond"/>
      <variable name="k_AP_AI" units="per_millisecond"/>
      <variable initial_value="0.0000875" name="k_AI_AP" units="per_millisecond"/>
      <variable name="k_RP_RI" units="per_millisecond"/>
      <variable name="k_RI_RP" units="per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_RP_Na</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_AP_Na</ci>
                     <ci>k_AP_RP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_RI_Na</ci>
                     <ci>k_RI_RP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_RP_Na</ci>
                  <apply>
                     <plus/>
                     <ci>k_RP_RI</ci>
                     <ci>k_RP_AP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_AP_Na</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_RP_Na</ci>
                     <ci>k_RP_AP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_AI_Na</ci>
                     <ci>k_AI_AP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_AP_Na</ci>
                  <apply>
                     <plus/>
                     <ci>k_AP_RP</ci>
                     <ci>k_AP_AI</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_AI_Na</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_RI_Na</ci>
                     <ci>k_RI_AI</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_AP_Na</ci>
                     <ci>k_AP_AI</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_AI_Na</ci>
                  <apply>
                     <plus/>
                     <ci>k_AI_RI</ci>
                     <ci>k_AI_AP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_RI_Na</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>p_RP_Na</ci>
                  </apply>
                  <ci>p_AP_Na</ci>
               </apply>
               <ci>p_AI_Na</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RP_AP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_AP_RP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">26</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">800</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_AP_AI</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>Vm</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_AI_RI</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1300</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.04</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">800</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RI_AI</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0001027</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RP_RI</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>k_AI_AP</ci>
                        <ci>k_AP_RP</ci>
                        <ci>k_RI_AI</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k_AP_AI</ci>
                        <ci>k_RP_AP</ci>
                        <ci>k_AI_RI</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RI_RP</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01</cn>
               <ci>k_RP_RI</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_current_ultra_slow_gate">
      <variable initial_value="0.5861887862983165" name="y" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y" units="per_millisecond"/>
      <variable name="beta_y" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9000000000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.014</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y</ci>
                  <ci>y</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="picoA"/>
      <variable name="i_CaL_Na" public_interface="out" units="picoA"/>
      <variable name="i_CaL_Ca" public_interface="out" units="picoA"/>
      <variable name="i_CaL_K" public_interface="out" units="picoA"/>
      <variable name="p_open_CaL" private_interface="out" public_interface="out" units="dimensionless"/>
      <variable name="CaDiadic" private_interface="in" public_interface="out" units="picoA"/>
      <variable initial_value="8712" name="P_CaL" units="picoA_per_millimolar"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="CF_Na" public_interface="in" units="millimolar"/>
      <variable name="CF_Ca" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="CF_K" public_interface="in" units="millimolar"/>
      <variable name="ATPi" public_interface="in" units="millimolar"/>
      <variable name="p_AP_CaL" private_interface="in" units="dimensionless"/>
      <variable name="p_U" private_interface="in" units="dimensionless"/>
      <variable name="p_UCa" private_interface="in" units="dimensionless"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <plus/>
               <ci>i_CaL_Na</ci>
               <ci>i_CaL_Ca</ci>
               <ci>i_CaL_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_Ca</ci>
            <apply>
               <times/>
               <ci>P_CaL</ci>
               <ci>CF_Ca</ci>
               <ci>p_open_CaL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_Na</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0000185</cn>
               <ci>P_CaL</ci>
               <ci>CF_Na</ci>
               <ci>p_open_CaL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_K</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000365</cn>
               <ci>P_CaL</ci>
               <ci>CF_K</ci>
               <ci>p_open_CaL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_open_CaL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>p_AP_CaL</ci>
                  <apply>
                     <plus/>
                     <ci>p_U</ci>
                     <ci>p_UCa</ci>
                  </apply>
                  <ci>y</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1.4</cn>
                        <ci>ATPi</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_voltage_dependent_gate">
      <variable initial_value="1.5445004166497696e-6" name="p_AP_CaL" public_interface="out" units="dimensionless"/>
      <variable name="p_RI_CaL" units="dimensionless"/>
      <variable initial_value="0.9968480629364956" name="p_RP_CaL" units="dimensionless"/>
      <variable initial_value="8.77325391245903e-4" name="p_AI_CaL" units="dimensionless"/>
      <variable name="k_RP_AP" units="per_millisecond"/>
      <variable name="k_AP_RP" units="per_millisecond"/>
      <variable name="k_RI_AI" units="per_millisecond"/>
      <variable name="k_AI_RI" units="per_millisecond"/>
      <variable initial_value="0.004" name="k_AP_AI" units="per_millisecond"/>
      <variable initial_value="0.001" name="k_AI_AP" units="per_millisecond"/>
      <variable name="k_RP_RI" units="per_millisecond"/>
      <variable name="k_RI_RP" units="per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_RP_CaL</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_AP_CaL</ci>
                     <ci>k_AP_RP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_RI_CaL</ci>
                     <ci>k_RI_RP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_RP_CaL</ci>
                  <apply>
                     <plus/>
                     <ci>k_RP_RI</ci>
                     <ci>k_RP_AP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_AP_CaL</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_RP_CaL</ci>
                     <ci>k_RP_AP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_AI_CaL</ci>
                     <ci>k_AI_AP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_AP_CaL</ci>
                  <apply>
                     <plus/>
                     <ci>k_AP_RP</ci>
                     <ci>k_AP_AI</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_AI_CaL</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_RI_CaL</ci>
                     <ci>k_RI_AI</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_AP_CaL</ci>
                     <ci>k_AP_AI</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_AI_CaL</ci>
                  <apply>
                     <plus/>
                     <ci>k_AI_RI</ci>
                     <ci>k_AI_AP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_RI_CaL</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>p_AP_CaL</ci>
                  </apply>
                  <ci>p_RP_CaL</ci>
               </apply>
               <ci>p_AI_CaL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RP_AP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.27</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.9</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_AP_RP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">480</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RI_AI</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0018</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.4</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_AI_RI</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2200000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.4</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RP_RI</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>k_AI_AP</ci>
                        <ci>k_AP_RP</ci>
                        <ci>k_RI_AI</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k_AP_AI</ci>
                        <ci>k_RP_AP</ci>
                        <ci>k_AI_RI</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_RI_RP</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
               <ci>k_RP_RI</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_Ca_dependent_gate">
      <variable initial_value="0.17246483915629204" name="p_U" public_interface="out" units="dimensionless"/>
      <variable initial_value="6.098246017787626e-5" name="p_UCa" public_interface="out" units="dimensionless"/>
      <variable name="iCaL" units="picoA"/>
      <variable name="Cacm" units="millimolar"/>
      <variable name="p_CCa" units="dimensionless"/>
      <variable initial_value="0.4250747299372254" name="p_C" units="dimensionless"/>
      <variable initial_value="0.0003" name="k_CCa_UCa" units="per_millisecond"/>
      <variable initial_value="0.35" name="k_UCa_CCa" units="per_millisecond"/>
      <variable initial_value="0.143" name="k_C_U" units="per_millisecond"/>
      <variable initial_value="0.35" name="k_U_C" units="per_millisecond"/>
      <variable name="k_UCa_U" units="per_millisecond"/>
      <variable initial_value="6.954" name="k_U_UCa" units="per_millimolar_millisecond"/>
      <variable initial_value="0.0042" name="k_CCa_C" units="per_millisecond"/>
      <variable initial_value="6.954" name="k_C_CCa" units="per_millimolar_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="CF_Ca" public_interface="in" units="millimolar"/>
      <variable name="p_AP_CaL" public_interface="in" units="dimensionless"/>
      <variable name="CaEffC" units="millimolar"/>
      <variable name="CaEffU" units="millimolar"/>
      <variable name="k_UUCa_Ca" units="per_millisecond"/>
      <variable name="k_CCCa_Ca" units="per_millisecond"/>
      <variable name="CaDiadic" public_interface="out" units="picoA"/>
      <variable name="p_open_CaL" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>iCaL</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picoA_per_millimolar">0.0676</cn>
               <ci>CF_Ca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CaDiadic</ci>
            <apply>
               <times/>
               <ci>iCaL</ci>
               <ci>p_open_CaL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Cacm</ci>
            <apply>
               <minus/>
               <ci>Cai</ci>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar_per_picoA">0.3</cn>
                  <ci>iCaL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CaEffC</ci>
            <apply>
               <times/>
               <ci>Cacm</ci>
               <ci>p_AP_CaL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CaEffU</ci>
            <apply>
               <plus/>
               <ci>CaEffC</ci>
               <apply>
                  <times/>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>p_AP_CaL</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_UUCa_Ca</ci>
            <apply>
               <times/>
               <ci>k_U_UCa</ci>
               <ci>CaEffU</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k_CCCa_Ca</ci>
            <apply>
               <times/>
               <ci>k_C_CCa</ci>
               <ci>CaEffC</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_U</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_C</ci>
                     <ci>k_C_U</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_UCa</ci>
                     <ci>k_UCa_U</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_U</ci>
                  <apply>
                     <plus/>
                     <ci>k_UUCa_Ca</ci>
                     <ci>k_U_C</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_UCa</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_U</ci>
                     <ci>k_UUCa_Ca</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_CCa</ci>
                     <ci>k_CCa_UCa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>p_UCa</ci>
                  <apply>
                     <plus/>
                     <ci>k_UCa_CCa</ci>
                     <ci>k_UCa_U</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_C</ci>
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            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>p_CCa</ci>
                     <ci>k_CCa_C</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>p_U</ci>
                     <ci>k_U_C</ci>
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               </apply>
               <apply>
                  <times/>
                  <ci>p_C</ci>
                  <apply>
                     <plus/>
                     <ci>k_C_U</ci>
                     <apply>
                        <times/>
                        <ci>k_C_CCa</ci>
                        <ci>Cacm</ci>
                        <ci>p_AP_CaL</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_CCa</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>p_C</ci>
                  </apply>
                  <ci>p_U</ci>
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               <ci>p_UCa</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>k_UCa_U</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>k_CCa_C</ci>
                  <ci>k_C_U</ci>
                  <ci>k_U_UCa</ci>
                  <ci>k_UCa_CCa</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_U_C</ci>
                  <ci>k_C_CCa</ci>
                  <ci>k_CCa_UCa</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_ultra_slow_gate">
      <variable initial_value="0.9985266538252986" name="y" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y" units="per_millisecond"/>
      <variable name="beta_y" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">250000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">58</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1800</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">66</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y</ci>
                  <ci>y</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel">
      <variable cmeta:id="T_type_Ca_channel_i_Ca_T" name="i_Ca_T" public_interface="out" units="picoA"/>
      <variable initial_value="612" name="P_CaT" units="picoA_per_millimolar"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="CF_Ca" public_interface="in" units="millimolar"/>
      <variable name="y1" private_interface="in" units="dimensionless"/>
      <variable name="y2" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>P_CaT</ci>
               <ci>CF_Ca</ci>
               <ci>y1</ci>
               <ci>y2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_y1_gate">
      <variable initial_value="1.6882718240109127e-5" name="y1" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y1" units="per_millisecond"/>
      <variable name="beta_y1" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.019</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.6</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.82</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">250</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">40</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.3</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10000</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y1</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y1</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y1</ci>
                  <ci>y1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_y2_gate">
      <variable initial_value="0.8585352091865849" name="y2" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y2" units="per_millisecond"/>
      <variable name="beta_y2" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">62000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.1</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">30</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3000</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0006</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.7</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y2</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y2</ci>
                  <ci>y2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="picoA"/>
      <variable name="E_K" private_interface="out" public_interface="out" units="millivolt"/>
      <variable name="g_K1" units="nanoS"/>
      <variable initial_value="1.146" name="P_K1_0" units="nanoS_per_picoF"/>
      <variable name="fO" private_interface="out" units="dimensionless"/>
      <variable name="fO2" units="dimensionless"/>
      <variable name="fO3" units="dimensionless"/>
      <variable name="fO4" units="dimensionless"/>
      <variable name="fB" units="dimensionless"/>
      <variable name="mu" units="per_millisecond"/>
      <variable name="lambda" units="per_millisecond"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>g_K1</ci>
               <apply>
                  <minus/>
                  <ci>Vm</ci>
                  <ci>E_K</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>fO4</ci>
                  <ci>fO3</ci>
                  <ci>fO2</ci>
               </apply>
               <ci>y</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <ci>P_K1_0</ci>
               <ci>Cm</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fB</ci>
            <apply>
               <divide/>
               <ci>mu</ci>
               <apply>
                  <plus/>
                  <ci>mu</ci>
                  <ci>lambda</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fO</ci>
            <apply>
               <divide/>
               <ci>lambda</ci>
               <apply>
                  <plus/>
                  <ci>mu</ci>
                  <ci>lambda</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fO2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               <apply>
                  <power/>
                  <ci>fO</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <power/>
                  <ci>fB</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fO3</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <apply>
                  <power/>
                  <ci>fO</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>fB</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fO4</ci>
            <apply>
               <power/>
               <ci>fO</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.75</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.035</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.015</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">140</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>lambda</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.048</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.064</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>Vm</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current_y_gate">
      <variable initial_value="0.6080573900752752" name="y" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y" units="per_millisecond"/>
      <variable name="beta_y" units="per_millisecond"/>
      <variable name="fO" public_interface="in" units="dimensionless"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>Vm</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>Vm</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>fO</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00014</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>Vm</ci>
                                    <ci>E_K</ci>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9.1</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>Vm</ci>
                                    <ci>E_K</ci>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">500</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y</ci>
                  <ci>y</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_time_dependent_potassium_current">
      <variable cmeta:id="rapid_time_dependent_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="picoA"/>
      <variable name="g_Kr" units="nanoS"/>
      <variable initial_value="0.00864" name="P_Kr" units="nanoS_per_picoF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="E_K" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="y1" private_interface="in" units="dimensionless"/>
      <variable name="y2" private_interface="in" units="dimensionless"/>
      <variable name="y3" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <apply>
                  <minus/>
                  <ci>Vm</ci>
                  <ci>E_K</ci>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                     <ci>y1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
                     <ci>y2</ci>
                  </apply>
               </apply>
               <ci>y3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Kr</ci>
            <apply>
               <times/>
               <ci>P_Kr</ci>
               <ci>Cm</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_time_dependent_potassium_current_y1_gate">
      <variable initial_value="0.0018339931180983765" name="y1" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y1" units="per_millisecond"/>
      <variable name="beta_y1" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">20</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y1</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">160</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <ci>Vm</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">200</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <ci>Vm</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1000</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2500</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y1</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y1</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y1</ci>
                  <ci>y1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_time_dependent_potassium_current_y2_gate">
      <variable initial_value="0.20443083454225305" name="y2" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y2" units="per_millisecond"/>
      <variable name="beta_y2" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">200</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">20</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y2</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1600</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <ci>Vm</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2000</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <ci>Vm</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1000</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10000</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y2</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y2</ci>
                  <ci>y2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_time_dependent_potassium_current_y3_gate">
      <variable initial_value="0.967887666264921" name="y3" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y3" units="per_millisecond"/>
      <variable name="beta_y3" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y3</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.5</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y3</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.35</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y3</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y3</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y3</ci>
                  <ci>y3</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_time_dependent_potassium_current">
      <variable cmeta:id="slow_time_dependent_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="picoA"/>
      <variable name="i_Ks_Na" public_interface="out" units="picoA"/>
      <variable name="i_Ks_K" public_interface="out" units="picoA"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="CF_K" public_interface="in" units="millimolar"/>
      <variable name="CF_Na" public_interface="in" units="millimolar"/>
      <variable name="y1" private_interface="in" units="dimensionless"/>
      <variable name="y2" private_interface="in" units="dimensionless"/>
      <variable initial_value="5.04" name="P_Ks_K" units="picoA_per_millimolar"/>
      <variable initial_value="0.2016" name="P_Ks_Na" units="picoA_per_millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <plus/>
               <ci>i_Ks_Na</ci>
               <ci>i_Ks_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks_K</ci>
            <apply>
               <times/>
               <ci>P_Ks_K</ci>
               <ci>CF_K</ci>
               <apply>
                  <power/>
                  <ci>y1</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                     <ci>y2</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks_Na</ci>
            <apply>
               <times/>
               <ci>P_Ks_Na</ci>
               <ci>CF_Na</ci>
               <apply>
                  <power/>
                  <ci>y1</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                     <ci>y2</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_time_dependent_potassium_current_y1_gate">
      <variable initial_value="0.09738789658609195" name="y1" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y1" units="per_millisecond"/>
      <variable name="beta_y1" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">85</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">370</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">62</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1450</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">260</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y1</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y1</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y1</ci>
                  <ci>y1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_time_dependent_potassium_current_y2_gate">
      <variable initial_value="0.09745345578743213" name="y2" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y2" units="per_millisecond"/>
      <variable initial_value="0.004444" name="beta_y2" units="per_millisecond"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millimolar_millisecond">3.7</cn>
               <ci>Cai</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y2</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y2</ci>
                  <ci>y2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current">
      <variable cmeta:id="transient_outward_current_i_to" name="i_to" public_interface="out" units="picoA"/>
      <variable name="i_to_Na" public_interface="out" units="picoA"/>
      <variable name="i_to_K" public_interface="out" units="picoA"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="CF_K" public_interface="in" units="millimolar"/>
      <variable name="CF_Na" public_interface="in" units="millimolar"/>
      <variable name="y1" private_interface="in" units="dimensionless"/>
      <variable name="y2" private_interface="in" units="dimensionless"/>
      <variable initial_value="0.033" name="P_to_K" units="picoA_per_millimolar"/>
      <variable initial_value="0.00297" name="P_to_Na" units="picoA_per_millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <plus/>
               <ci>i_to_Na</ci>
               <ci>i_to_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to_K</ci>
            <apply>
               <times/>
               <ci>P_to_K</ci>
               <ci>CF_K</ci>
               <apply>
                  <power/>
                  <ci>y1</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>y2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to_Na</ci>
            <apply>
               <times/>
               <ci>P_to_Na</ci>
               <ci>CF_Na</ci>
               <apply>
                  <power/>
                  <ci>y1</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>y2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_y1_gate">
      <variable initial_value="7.956883250874798e-4" name="y1" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y1" units="per_millisecond"/>
      <variable name="beta_y1" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>Vm</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.4</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">500</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y1</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y1</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y1</ci>
                  <ci>y1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_y2_gate">
      <variable initial_value="0.9999125083105881" name="y2" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y2" units="per_millisecond"/>
      <variable name="beta_y2" units="per_millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y2</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0038</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>Vm</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.051335</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>Vm</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y2</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0038</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.067083</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>Vm</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y2</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y2</ci>
                  <ci>y2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="background_NSC_current">
      <variable cmeta:id="background_NSC_current_i_bNSC" name="i_bNSC" public_interface="out" units="picoA"/>
      <variable name="i_bNSC_Na" public_interface="out" units="picoA"/>
      <variable name="i_bNSC_K" public_interface="out" units="picoA"/>
      <variable initial_value="0.385" name="P_bNSC" units="picoA_per_millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="CF_K" public_interface="in" units="millimolar"/>
      <variable name="CF_Na" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_bNSC</ci>
            <apply>
               <plus/>
               <ci>i_bNSC_K</ci>
               <ci>i_bNSC_Na</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_bNSC_K</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
               <ci>P_bNSC</ci>
               <ci>CF_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_bNSC_Na</ci>
            <apply>
               <times/>
               <ci>P_bNSC</ci>
               <ci>CF_Na</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="background_Kpl_current">
      <variable cmeta:id="background_Kpl_current_i_Kpl" name="i_Kpl" public_interface="out" units="picoA"/>
      <variable name="P_Kpl" units="nanoS_per_millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="CF_K" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kpl</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <ci>P_Kpl</ci>
                     <ci>CF_K</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.0077</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Vm</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Kpl</ci>
                        <ci>CF_K</ci>
                        <apply>
                           <plus/>
                           <ci>Vm</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>Vm</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>P_Kpl</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoS_per_millimolar">0.00011</cn>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.16</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="background_lCa_current">
      <variable name="i_lCa" public_interface="out" units="picoA"/>
      <variable name="i_lCa_Na" public_interface="out" units="picoA"/>
      <variable name="i_lCa_K" public_interface="out" units="picoA"/>
      <variable initial_value="0.11" name="P_lCa" units="picoA_per_millimolar"/>
      <variable name="p_open" units="dimensionless"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="CF_K" public_interface="in" units="millimolar"/>
      <variable name="CF_Na" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_lCa</ci>
            <apply>
               <plus/>
               <ci>i_lCa_K</ci>
               <ci>i_lCa_Na</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_lCa_K</ci>
            <apply>
               <times/>
               <ci>P_lCa</ci>
               <ci>CF_K</ci>
               <ci>p_open</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_lCa_Na</ci>
            <apply>
               <times/>
               <ci>P_lCa</ci>
               <ci>CF_Na</ci>
               <ci>p_open</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_open</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0012</cn>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="background_KATP_current">
      <variable cmeta:id="background_KATP_current_i_KATP" name="i_KATP" public_interface="out" units="picoA"/>
      <variable name="p_open" units="dimensionless"/>
      <variable name="gamma" units="nanoS"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="ATPi" public_interface="in" units="millimolar"/>
      <variable initial_value="0.0236" name="P_KATP" units="nanoS_per_picoF"/>
      <variable initial_value="2333" name="N" units="picoF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_KATP</ci>
            <apply>
               <times/>
               <ci>gamma</ci>
               <apply>
                  <minus/>
                  <ci>Vm</ci>
                  <ci>E_K</ci>
               </apply>
               <ci>p_open</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gamma</ci>
            <apply>
               <times/>
               <ci>P_KATP</ci>
               <ci>N</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.24</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_open</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ATPi</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.1</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="background_Cab_current">
      <variable cmeta:id="background_Cab_current_i_Cab" name="i_Cab" public_interface="out" units="picoA"/>
      <variable initial_value="0.04" name="P_Cab" units="picoA_per_millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="CF_Ca" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Cab</ci>
            <apply>
               <times/>
               <ci>P_Cab</ci>
               <ci>CF_Ca</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_calcium_exchanger">
      <variable cmeta:id="sodium_calcium_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="picoA"/>
      <variable name="p_E2Na" private_interface="out" units="dimensionless"/>
      <variable name="p_E1Na" private_interface="out" units="dimensionless"/>
      <variable name="p_E1Ca" private_interface="out" units="dimensionless"/>
      <variable name="p_E2Ca" private_interface="out" units="dimensionless"/>
      <variable name="k1" private_interface="out" units="per_millisecond"/>
      <variable name="k2" private_interface="out" units="per_millisecond"/>
      <variable initial_value="1" name="k3" private_interface="out" units="per_millisecond"/>
      <variable initial_value="1" name="k4" private_interface="out" units="per_millisecond"/>
      <variable initial_value="8.75" name="Km_Nai" units="millimolar"/>
      <variable initial_value="87.5" name="Km_Nao" units="millimolar"/>
      <variable initial_value="0.00138" name="Km_Cai" units="millimolar"/>
      <variable initial_value="1.38" name="Km_Cao" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <variable initial_value="6.81" name="P_NaCa" units="picoA_per_picoF"/>
      <variable initial_value="0.32" name="Partition" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <times/>
               <ci>P_NaCa</ci>
               <ci>Cm</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>k1</ci>
                     <ci>p_E1Na</ci>
                     <ci>y</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k2</ci>
                     <ci>p_E2Na</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>y</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E1Na</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Nai</ci>
                           <ci>Nai</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <ci>Cai</ci>
                           <ci>Km_Cai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E2Na</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Nao</ci>
                           <ci>Nao</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <ci>Cao</ci>
                           <ci>Km_Cao</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E1Ca</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>Km_Cai</ci>
                        <ci>Cai</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Nai</ci>
                              <ci>Km_Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E2Ca</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>Km_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Nao</ci>
                              <ci>Km_Nao</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Partition</ci>
                        <ci>F</ci>
                        <ci>Vm</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>Partition</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                        <ci>F</ci>
                        <ci>Vm</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_calcium_exchanger_y_gate">
      <variable initial_value="0.9891789193465331" name="y" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y" units="per_millisecond"/>
      <variable name="beta_y" units="per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="p_E1Na" public_interface="in" units="dimensionless"/>
      <variable name="p_E2Na" public_interface="in" units="dimensionless"/>
      <variable name="p_E1Ca" public_interface="in" units="dimensionless"/>
      <variable name="p_E2Ca" public_interface="in" units="dimensionless"/>
      <variable name="k1" public_interface="in" units="per_millisecond"/>
      <variable name="k2" public_interface="in" units="per_millisecond"/>
      <variable name="k3" public_interface="in" units="per_millisecond"/>
      <variable name="k4" public_interface="in" units="per_millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k2</ci>
                  <ci>p_E2Na</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k4</ci>
                  <ci>p_E2Ca</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k1</ci>
                  <ci>p_E1Na</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k3</ci>
                  <ci>p_E1Ca</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y</ci>
                  <ci>y</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="picoA"/>
      <variable name="p_E2Na" private_interface="out" units="dimensionless"/>
      <variable name="p_E1Na" private_interface="out" units="dimensionless"/>
      <variable name="p_E1K" private_interface="out" units="dimensionless"/>
      <variable name="p_E2K" private_interface="out" units="dimensionless"/>
      <variable name="k1" private_interface="out" units="per_millisecond"/>
      <variable initial_value="0.04" name="k2" private_interface="out" units="per_millisecond"/>
      <variable initial_value="0.01" name="k3" private_interface="out" units="per_millisecond"/>
      <variable initial_value="0.165" name="k4" private_interface="out" units="per_millisecond"/>
      <variable initial_value="4.05" name="Km_Nai" units="millimolar"/>
      <variable initial_value="69.8" name="Km_Nao" units="millimolar"/>
      <variable initial_value="32.88" name="Km_Ki" units="millimolar"/>
      <variable initial_value="0.258" name="Km_Ko" units="millimolar"/>
      <variable initial_value="0.094" name="Km_ATP" units="millimolar"/>
      <variable name="Nao_Eff" units="millimolar"/>
      <variable name="ATPi" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Vm" public_interface="in" units="millivolt"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <variable initial_value="21" name="P_NaK" units="picoA_per_picoF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <times/>
               <ci>P_NaK</ci>
               <ci>Cm</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>k1</ci>
                     <ci>p_E1Na</ci>
                     <ci>y</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k2</ci>
                     <ci>p_E2Na</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>y</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E1Na</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Nai</ci>
                           <ci>Nai</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Ki</ci>
                              <ci>Km_Ki</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E2Na</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Nao</ci>
                           <ci>Nao_Eff</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Ko</ci>
                              <ci>Km_Ko</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E1K</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Ki</ci>
                           <ci>Ki</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Nai</ci>
                              <ci>Km_Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E2K</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Ko</ci>
                           <ci>Ko</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Nao_Eff</ci>
                              <ci>Km_Nao</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.37</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Km_ATP</ci>
                     <ci>ATPi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Nao_Eff</ci>
            <apply>
               <times/>
               <ci>Nao</ci>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.82</cn>
                        </apply>
                        <ci>F</ci>
                        <ci>Vm</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump_y_gate">
      <variable initial_value="0.5910747147428818" name="y" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y" units="per_millisecond"/>
      <variable name="beta_y" units="per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="p_E1Na" public_interface="in" units="dimensionless"/>
      <variable name="p_E2Na" public_interface="in" units="dimensionless"/>
      <variable name="p_E1K" public_interface="in" units="dimensionless"/>
      <variable name="p_E2K" public_interface="in" units="dimensionless"/>
      <variable name="k1" public_interface="in" units="per_millisecond"/>
      <variable name="k2" public_interface="in" units="per_millisecond"/>
      <variable name="k3" public_interface="in" units="per_millisecond"/>
      <variable name="k4" public_interface="in" units="per_millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k2</ci>
                  <ci>p_E2Na</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k4</ci>
                  <ci>p_E2K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k1</ci>
                  <ci>p_E1Na</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k3</ci>
                  <ci>p_E1K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y</ci>
                  <ci>y</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="SR_calcium_pump">
      <variable name="i_SR_U" public_interface="out" units="picoA"/>
      <variable name="p_E2Ca" private_interface="out" units="dimensionless"/>
      <variable name="p_E1Ca" private_interface="out" units="dimensionless"/>
      <variable name="p_E1" private_interface="out" units="dimensionless"/>
      <variable name="p_E2" private_interface="out" units="dimensionless"/>
      <variable initial_value="0.01" name="k1" private_interface="out" units="per_millisecond"/>
      <variable name="k2" private_interface="out" units="per_millisecond"/>
      <variable initial_value="1" name="k3" private_interface="out" units="per_millisecond"/>
      <variable initial_value="0.01" name="k4" private_interface="out" units="per_millisecond"/>
      <variable initial_value="0.08" name="Km_CaSR" units="millimolar"/>
      <variable initial_value="0.0008" name="Km_CaCyto" units="millimolar"/>
      <variable initial_value="0.1" name="Km_ATP" units="millimolar"/>
      <variable initial_value="162500" name="i_max" units="picoA"/>
      <variable name="ATPi" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Caup" public_interface="in" units="millimolar"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_SR_U</ci>
            <apply>
               <times/>
               <ci>i_max</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>k1</ci>
                     <ci>p_E1Ca</ci>
                     <ci>y</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k2</ci>
                     <ci>p_E2Ca</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>y</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E1Ca</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Km_CaSR</ci>
                     <ci>Caup</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E2Ca</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Km_CaCyto</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E1</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>p_E1Ca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_E2</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>p_E2Ca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Km_ATP</ci>
                     <ci>ATPi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="SR_calcium_pump_y_gate">
      <variable initial_value="0.46108441538480216" name="y" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y" units="per_millisecond"/>
      <variable name="beta_y" units="per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="p_E1Ca" public_interface="in" units="dimensionless"/>
      <variable name="p_E2Ca" public_interface="in" units="dimensionless"/>
      <variable name="p_E1" public_interface="in" units="dimensionless"/>
      <variable name="p_E2" public_interface="in" units="dimensionless"/>
      <variable name="k1" public_interface="in" units="per_millisecond"/>
      <variable name="k2" public_interface="in" units="per_millisecond"/>
      <variable name="k3" public_interface="in" units="per_millisecond"/>
      <variable name="k4" public_interface="in" units="per_millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_y</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k2</ci>
                  <ci>p_E2Ca</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k4</ci>
                  <ci>p_E2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k1</ci>
                  <ci>p_E1Ca</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k3</ci>
                  <ci>p_E1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y</ci>
                  <ci>y</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="RyR_channel">
      <variable name="i_RyR" public_interface="out" units="picoA"/>
      <variable initial_value="62000" name="P_RyR" units="picoA_per_millimolar"/>
      <variable name="k1" units="per_millisecond"/>
      <variable name="k2" units="per_millisecond"/>
      <variable name="k3" units="per_millisecond"/>
      <variable initial_value="0.000849" name="k4" units="per_millisecond"/>
      <variable initial_value="3.4314360001543243e-4" name="p_open_RyR" units="dimensionless"/>
      <variable initial_value="0.19135178123107768" name="p_close_RyR" units="dimensionless"/>
      <variable name="p_open_CaL" public_interface="in" units="dimensionless"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Carel" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable initial_value="-150" name="Diadid_Factor" units="per_picoA_millisecond"/>
      <variable name="CaDiadic" public_interface="in" units="picoA"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_RyR</ci>
            <apply>
               <times/>
               <ci>P_RyR</ci>
               <apply>
                  <minus/>
                  <ci>Carel</ci>
                  <ci>Cai</ci>
               </apply>
               <ci>p_open_RyR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_open_RyR</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>p_close_RyR</ci>
                  <ci>k1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>p_open_RyR</ci>
                  <ci>k2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>p_close_RyR</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k3</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <ci>p_open_RyR</ci>
                        <ci>p_close_RyR</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>k1</ci>
                     <ci>k4</ci>
                  </apply>
                  <ci>p_close_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">280000</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Cai</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>Diadid_Factor</ci>
                  <ci>CaDiadic</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.08</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.36</cn>
                     <ci>Carel</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k3</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.000377</cn>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Carel</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="SR_T_current">
      <variable name="i_SR_T" public_interface="out" units="picoA"/>
      <variable initial_value="386" name="P_SR_T" units="picoA_per_millimolar"/>
      <variable name="Carel" public_interface="in" units="millimolar"/>
      <variable name="Caup" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_SR_T</ci>
            <apply>
               <times/>
               <ci>P_SR_T</ci>
               <apply>
                  <minus/>
                  <ci>Caup</ci>
                  <ci>Carel</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="SR_L_current">
      <variable name="i_SR_L" public_interface="out" units="picoA"/>
      <variable initial_value="459" name="P_SR_L" units="picoA_per_millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Caup" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_SR_L</ci>
            <apply>
               <times/>
               <ci>P_SR_L</ci>
               <apply>
                  <minus/>
                  <ci>Caup</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_concentrations_in_SR">
      <variable initial_value="9.455741736977666" name="Ca_Total" units="millimolar"/>
      <variable cmeta:id="Ca_concentrations_in_SR_Carel" name="Carel" public_interface="out" units="millimolar"/>
      <variable cmeta:id="Ca_concentrations_in_SR_Caup" initial_value="2.611712901567567" name="Caup" public_interface="out" units="millimolar"/>
      <variable cmeta:id="Ca_concentrations_in_SR_V_rel" initial_value="160" name="V_rel" units="micrometre3"/>
      <variable cmeta:id="Ca_concentrations_in_SR_V_up" initial_value="400" name="V_up" units="micrometre3"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="i_SR_L" public_interface="in" units="picoA"/>
      <variable name="i_SR_T" public_interface="in" units="picoA"/>
      <variable name="i_RyR" public_interface="in" units="picoA"/>
      <variable name="i_SR_U" public_interface="in" units="picoA"/>
      <variable initial_value="10" name="CSQN_max" units="millimolar"/>
      <variable initial_value="0.8" name="K_mCSQN" units="millimolar"/>
      <variable name="b1" units="millimolar"/>
      <variable name="c1" units="millimolar2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>b1</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>CSQN_max</ci>
                  <ci>Ca_Total</ci>
               </apply>
               <ci>K_mCSQN</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>c1</ci>
            <apply>
               <times/>
               <ci>K_mCSQN</ci>
               <ci>Ca_Total</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Carel</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <root/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <ci>b1</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>c1</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>b1</ci>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_Total</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>i_SR_T</ci>
                  <ci>i_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>F</ci>
                  <ci>V_rel</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Caup</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>i_SR_U</ci>
                     </apply>
                     <ci>i_SR_T</ci>
                  </apply>
                  <ci>i_SR_L</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>F</ci>
                  <ci>V_up</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="NL_model">
      <variable name="dCaidt" public_interface="out" units="millimolar_per_millisecond"/>
      <variable name="dATPdt" public_interface="out" units="millimolar_per_millisecond"/>
      <variable name="EffFraction" units="dimensionless"/>
      <variable initial_value="0.02490898775497523" name="pCa" units="dimensionless"/>
      <variable initial_value="0.001990153835322864" name="pCaCB" units="dimensionless"/>
      <variable initial_value="4.2941813853474524e-4" name="pCB" units="dimensionless"/>
      <variable name="p" units="dimensionless"/>
      <variable initial_value="0.07" name="T_t" units="millimolar"/>
      <variable name="Q_a" units="per_millisecond"/>
      <variable name="Q_b" units="per_millisecond"/>
      <variable name="Q_r" units="per_millisecond"/>
      <variable name="Q_d" units="per_millisecond"/>
      <variable name="Q_d1" units="per_millisecond"/>
      <variable name="Q_d2" units="per_millisecond"/>
      <variable initial_value="39" name="Y_1" units="per_millimolar_millisecond"/>
      <variable initial_value="0.0039" name="Y_2" units="per_millisecond"/>
      <variable initial_value="0.03" name="Y_3" units="per_millisecond"/>
      <variable initial_value="0.12" name="Y_4" units="per_millisecond"/>
      <variable initial_value="0.027" name="Y_d" units="millisecond_per_micrometre2"/>
      <variable initial_value="0.03" name="Z_1" units="per_millisecond"/>
      <variable initial_value="0.0039" name="Z_2" units="per_millisecond"/>
      <variable initial_value="1560" name="Z_3" units="per_millimolar_millisecond"/>
      <variable name="h" units="micrometre"/>
      <variable initial_value="1.17" name="L_a" units="micrometre"/>
      <variable initial_value="0.9623799975411884" name="L" units="micrometre"/>
      <variable name="ForceCB" units="mN_per_mm2"/>
      <variable initial_value="0.9573749975411884" name="X" units="micrometre"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="NewCBF" units="mN_per_mm2_micrometre"/>
      <variable name="CBBound" units="millimolar"/>
      <variable initial_value="140000" name="KForceEC" units="mN_per_mm2_micrometre5"/>
      <variable initial_value="0.97" name="ZeroForceEL" units="micrometre"/>
      <variable initial_value="200" name="KForceLinearEc" units="mN_per_mm2_micrometre"/>
      <variable initial_value="1800000" name="ForceFactor" units="mN_per_mm2_micrometre_millimolar"/>
      <variable name="ForceEcomp" units="mN_per_mm2"/>
      <variable initial_value="1.2" name="B" units="per_millisecond"/>
      <variable initial_value="0.005" name="h_c" units="micrometre"/>
      <variable name="ForceExt" units="mN_per_mm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>h</ci>
            <apply>
               <minus/>
               <ci>L</ci>
               <ci>X</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>pCa</ci>
                  </apply>
                  <ci>pCaCB</ci>
               </apply>
               <ci>pCB</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Q_b</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>Y_1</ci>
                  <ci>Cai</ci>
                  <ci>p</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Z_1</ci>
                  <ci>pCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>EffFraction</ci>
            <apply>
               <exp/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_micrometre2">20</cn>
                  </apply>
                  <apply>
                     <power/>
                     <apply>
                        <minus/>
                        <ci>L</ci>
                        <ci>L_a</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Q_a</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>Y_2</ci>
                  <ci>pCa</ci>
                  <ci>EffFraction</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Z_2</ci>
                  <ci>pCaCB</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Q_r</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>Y_3</ci>
                  <ci>pCaCB</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Z_3</ci>
                  <ci>pCB</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Q_d</ci>
            <apply>
               <times/>
               <ci>Y_4</ci>
               <ci>pCB</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Q_d1</ci>
            <apply>
               <times/>
               <ci>Y_d</ci>
               <apply>
                  <power/>
                  <apply>
                     <diff/>
                     <bvar>
                        <ci>time</ci>
                     </bvar>
                     <ci>X</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <ci>pCB</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Q_d2</ci>
            <apply>
               <times/>
               <ci>Y_d</ci>
               <apply>
                  <power/>
                  <apply>
                     <diff/>
                     <bvar>
                        <ci>time</ci>
                     </bvar>
                     <ci>X</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <ci>pCaCB</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pCa</ci>
            </apply>
            <apply>
               <minus/>
               <ci>Q_b</ci>
               <ci>Q_a</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pCaCB</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>Q_a</ci>
                  <ci>Q_r</ci>
               </apply>
               <ci>Q_d2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pCB</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>Q_r</ci>
                  <ci>Q_d</ci>
               </apply>
               <ci>Q_d1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCaidt</ci>
            <apply>
               <times/>
               <ci>T_t</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>Q_d2</ci>
                     <ci>Q_r</ci>
                  </apply>
                  <ci>Q_b</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dATPdt</ci>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.4</cn>
               </apply>
               <ci>pCaCB</ci>
               <ci>T_t</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CBBound</ci>
            <apply>
               <times/>
               <ci>T_t</ci>
               <apply>
                  <plus/>
                  <ci>pCaCB</ci>
                  <ci>pCB</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NewCBF</ci>
            <apply>
               <times/>
               <ci>ForceFactor</ci>
               <ci>CBBound</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ForceEcomp</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>KForceEC</ci>
                  <apply>
                     <power/>
                     <apply>
                        <minus/>
                        <ci>ZeroForceEL</ci>
                        <ci>L</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>KForceLinearEc</ci>
                  <apply>
                     <minus/>
                     <ci>ZeroForceEL</ci>
                     <ci>L</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ForceCB</ci>
            <apply>
               <times/>
               <ci>NewCBF</ci>
               <ci>h</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ForceExt</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>ForceEcomp</ci>
               </apply>
               <ci>ForceCB</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>X</ci>
            </apply>
            <apply>
               <times/>
               <ci>B</ci>
               <apply>
                  <minus/>
                  <ci>h</ci>
                  <ci>h_c</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="internal_concentrations"/>
   <component name="intracellular_currents"/>
   <component name="transmembrane_currents"/>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="membrane">
         <component_ref component="internal_concentrations">
            <component_ref component="internal_ion_concentrations"/>
            <component_ref component="Ca_concentrations_in_SR"/>
            <component_ref component="constant_field_equations"/>
            <component_ref component="ATP_production"/>
            <component_ref component="NL_model"/>
         </component_ref>
         <component_ref component="transmembrane_currents">
            <component_ref component="sodium_current">
               <component_ref component="sodium_current_voltage_dependent_gate"/>
               <component_ref component="sodium_current_ultra_slow_gate"/>
            </component_ref>
            <component_ref component="L_type_Ca_channel">
               <component_ref component="L_type_Ca_channel_voltage_dependent_gate"/>
               <component_ref component="L_type_Ca_channel_Ca_dependent_gate"/>
               <component_ref component="L_type_Ca_channel_ultra_slow_gate"/>
            </component_ref>
            <component_ref component="T_type_Ca_channel">
               <component_ref component="T_type_Ca_channel_y1_gate"/>
               <component_ref component="T_type_Ca_channel_y2_gate"/>
            </component_ref>
            <component_ref component="time_independent_potassium_current">
               <component_ref component="time_independent_potassium_current_y_gate"/>
            </component_ref>
            <component_ref component="rapid_time_dependent_potassium_current">
               <component_ref component="rapid_time_dependent_potassium_current_y1_gate"/>
               <component_ref component="rapid_time_dependent_potassium_current_y2_gate"/>
               <component_ref component="rapid_time_dependent_potassium_current_y3_gate"/>
            </component_ref>
            <component_ref component="slow_time_dependent_potassium_current">
               <component_ref component="slow_time_dependent_potassium_current_y1_gate"/>
               <component_ref component="slow_time_dependent_potassium_current_y2_gate"/>
            </component_ref>
            <component_ref component="transient_outward_current">
               <component_ref component="transient_outward_current_y1_gate"/>
               <component_ref component="transient_outward_current_y2_gate"/>
            </component_ref>
            <component_ref component="background_NSC_current"/>
            <component_ref component="background_Kpl_current"/>
            <component_ref component="background_lCa_current"/>
            <component_ref component="background_Cab_current"/>
            <component_ref component="background_KATP_current"/>
            <component_ref component="sodium_calcium_exchanger">
               <component_ref component="sodium_calcium_exchanger_y_gate"/>
            </component_ref>
            <component_ref component="sodium_potassium_pump">
               <component_ref component="sodium_potassium_pump_y_gate"/>
            </component_ref>
         </component_ref>
         <component_ref component="intracellular_currents">
            <component_ref component="SR_calcium_pump">
               <component_ref component="SR_calcium_pump_y_gate"/>
            </component_ref>
            <component_ref component="RyR_channel"/>
            <component_ref component="SR_T_current"/>
            <component_ref component="SR_L_current"/>
         </component_ref>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="sodium_current">
         <component_ref component="sodium_current_voltage_dependent_gate"/>
         <component_ref component="sodium_current_ultra_slow_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_voltage_dependent_gate"/>
         <component_ref component="L_type_Ca_channel_Ca_dependent_gate"/>
         <component_ref component="L_type_Ca_channel_ultra_slow_gate"/>
      </component_ref>
      <component_ref component="T_type_Ca_channel">
         <component_ref component="T_type_Ca_channel_y1_gate"/>
         <component_ref component="T_type_Ca_channel_y2_gate"/>
      </component_ref>
      <component_ref component="time_independent_potassium_current">
         <component_ref component="time_independent_potassium_current_y_gate"/>
      </component_ref>
      <component_ref component="rapid_time_dependent_potassium_current">
         <component_ref component="rapid_time_dependent_potassium_current_y1_gate"/>
         <component_ref component="rapid_time_dependent_potassium_current_y2_gate"/>
         <component_ref component="rapid_time_dependent_potassium_current_y3_gate"/>
      </component_ref>
      <component_ref component="slow_time_dependent_potassium_current">
         <component_ref component="slow_time_dependent_potassium_current_y1_gate"/>
         <component_ref component="slow_time_dependent_potassium_current_y2_gate"/>
      </component_ref>
      <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_y1_gate"/>
         <component_ref component="transient_outward_current_y2_gate"/>
      </component_ref>
      <component_ref component="sodium_calcium_exchanger">
         <component_ref component="sodium_calcium_exchanger_y_gate"/>
      </component_ref>
      <component_ref component="sodium_potassium_pump">
         <component_ref component="sodium_potassium_pump_y_gate"/>
      </component_ref>
      <component_ref component="SR_calcium_pump">
         <component_ref component="SR_calcium_pump_y_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ATP_production" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="SR_T_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="SR_L_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_time_dependent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_time_dependent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="background_NSC_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="background_Kpl_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="background_lCa_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="background_KATP_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="background_Cab_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_calcium_exchanger" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="SR_calcium_pump" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="RyR_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_concentrations_in_SR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="NL_model" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="internal_ion_concentrations"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="i_ext" variable_2="i_ext"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="constant_field_equations"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="ATP_production"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_current"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="T_type_Ca_channel"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="rapid_time_dependent_potassium_current"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="slow_time_dependent_potassium_current"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="transient_outward_current"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="background_NSC_current"/>
      <map_variables variable_1="i_bNSC" variable_2="i_bNSC"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="background_Kpl_current"/>
      <map_variables variable_1="i_Kpl" variable_2="i_Kpl"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="background_lCa_current"/>
      <map_variables variable_1="i_lCa" variable_2="i_lCa"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="background_KATP_current"/>
      <map_variables variable_1="i_KATP" variable_2="i_KATP"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="background_Cab_current"/>
      <map_variables variable_1="i_Cab" variable_2="i_Cab"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_calcium_exchanger"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="Vm" variable_2="Vm"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="Ca_concentrations_in_SR"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="constant_field_equations"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="NL_model"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="dCaidt_NL" variable_2="dCaidt"/>
   </connection>
   <connection>
      <map_components component_1="external_ion_concentrations" component_2="constant_field_equations"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="external_ion_concentrations" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="external_ion_concentrations" component_2="rapid_time_dependent_potassium_current"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="external_ion_concentrations" component_2="background_Kpl_current"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="external_ion_concentrations" component_2="background_KATP_current"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="background_lCa_current"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="i_lCa_Na" variable_2="i_lCa_Na"/>
      <map_variables variable_1="i_lCa_K" variable_2="i_lCa_K"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="sodium_calcium_exchanger"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="external_ion_concentrations" component_2="sodium_calcium_exchanger"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="external_ion_concentrations" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="SR_calcium_pump"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="i_SR_U" variable_2="i_SR_U"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="RyR_channel"/>
      <map_variables variable_1="i_RyR" variable_2="i_RyR"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="SR_L_current"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="i_SR_L" variable_2="i_SR_L"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="sodium_current"/>
      <map_variables variable_1="i_Na_Na" variable_2="i_Na_Na"/>
      <map_variables variable_1="i_Na_K" variable_2="i_Na_K"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="i_CaL_Na" variable_2="i_CaL_Na"/>
      <map_variables variable_1="i_CaL_Ca" variable_2="i_CaL_Ca"/>
      <map_variables variable_1="i_CaL_K" variable_2="i_CaL_K"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="T_type_Ca_channel"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="rapid_time_dependent_potassium_current"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="slow_time_dependent_potassium_current"/>
      <map_variables variable_1="i_Ks_Na" variable_2="i_Ks_Na"/>
      <map_variables variable_1="i_Ks_K" variable_2="i_Ks_K"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="transient_outward_current"/>
      <map_variables variable_1="i_to_Na" variable_2="i_to_Na"/>
      <map_variables variable_1="i_to_K" variable_2="i_to_K"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="background_NSC_current"/>
      <map_variables variable_1="i_bNSC" variable_2="i_bNSC"/>
      <map_variables variable_1="i_bNSC_Na" variable_2="i_bNSC_Na"/>
      <map_variables variable_1="i_bNSC_K" variable_2="i_bNSC_K"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="background_Kpl_current"/>
      <map_variables variable_1="i_Kpl" variable_2="i_Kpl"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="background_KATP_current"/>
      <map_variables variable_1="i_KATP" variable_2="i_KATP"/>
   </connection>
   <connection>
      <map_components component_1="internal_ion_concentrations" component_2="background_Cab_current"/>
      <map_variables variable_1="i_Cab" variable_2="i_Cab"/>
   </connection>
   <connection>
      <map_components component_1="constant_field_equations" component_2="sodium_current"/>
      <map_variables variable_1="CF_Na" variable_2="CF_Na"/>
      <map_variables variable_1="CF_K" variable_2="CF_K"/>
   </connection>
   <connection>
      <map_components component_1="constant_field_equations" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="CF_Ca" variable_2="CF_Ca"/>
      <map_variables variable_1="CF_Na" variable_2="CF_Na"/>
      <map_variables variable_1="CF_K" variable_2="CF_K"/>
   </connection>
   <connection>
      <map_components component_1="constant_field_equations" component_2="T_type_Ca_channel"/>
      <map_variables variable_1="CF_Ca" variable_2="CF_Ca"/>
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    <rdf:value>Removed initial value for variable Vm_old, removing model overconstraint problem in PCEnv.</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#9c178f5d-ba61-4baa-b5e7-bd9b29eed314"/>
  </rdf:Description>

  <rdf:Description rdf:about="rdf:#9c178f5d-ba61-4baa-b5e7-bd9b29eed314">
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#7c4e2c38-c0c8-4fc1-9a60-f97f7a87d374"/>
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  <rdf:Description rdf:about="rdf:#72927c29-71c4-40b9-b313-d8114a40ac20">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Penny</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Noble</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">J</vCard:Other>

  </rdf:Description>
  <rdf:Description rdf:about="rdf:#45b24a15-d4e2-4142-9d6b-e2cfb4151eaa">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-10-30T11:57:22+13:00</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#4f1da377-87f0-4808-97f0-869e1359ec11">
    <vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Oxford University</vCard:Orgname>
    <vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Department of Physiology, Anatomy &amp; Genetics</vCard:Orgunit>

  </rdf:Description>
  <rdf:Description rdf:about="rdf:#52bb414e-a884-49bd-ad99-233709dc9cf3">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Shinobu</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Kuratomi</vCard:Family>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#b8a300ce-43dd-46a1-abae-5763f064bfe0">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-10-23T00:00:00+00:00</dcterms:W3CDTF>

  </rdf:Description>
  <rdf:Description rdf:about="rdf:#$CGvhb2">
    <ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">2000</ns7:endingValue>
    <ns7:nonstandard-pointDensity xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">10000</ns7:nonstandard-pointDensity>
    <ns7:maximumStepSize xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">0.1</ns7:maximumStepSize>
  </rdf:Description>
  <rdf:Description rdf:about="#matsuoka_sarai_kuratomi_ono_noma_2003">

    <ns7:simulation xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$AGvhb2"/>
    <bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#5e8bc23d-a6b6-4a3c-bb62-01b081f4303e"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource">
  <dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
    <bqs:subject_type>keyword</bqs:subject_type>
    <rdf:value>
      <rdf:Bag>
        <rdf:li>cardiac</rdf:li>
        <rdf:li>ventricular myocyte</rdf:li>
        <rdf:li>electrophysiology</rdf:li>
      </rdf:Bag>
    </rdf:value>
  </dc:subject>
</bqs:reference>
    <cmeta:comment rdf:resource="rdf:#66fafa6d-a88a-4a0d-bb05-183f0ba7182c"/>
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  <rdf:Description rdf:about="rdf:#868a1680-dad6-4412-8506-903d23fd0847">
    <vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#4f1da377-87f0-4808-97f0-869e1359ec11"/>
    <vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#322b339d-300e-4ff7-8aa8-80c3f754d3b8"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#72927c29-71c4-40b9-b313-d8114a40ac20"/>
  </rdf:Description>

  <rdf:Description rdf:about="rdf:#ff6605e2-beb8-4a61-a7d3-fd4388150776">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Kyoichi</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Ono</vCard:Family>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#a7ae93dd-06a4-418d-ae64-ac6eb647f6e4">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#52bb414e-a884-49bd-ad99-233709dc9cf3"/>
  </rdf:Description>

  <rdf:Description rdf:about="rdf:#d9a2749b-91d9-4fed-8c06-a19e41e42763">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#df111ee2-7a8f-41e1-b5c5-0a5e2719726c"/>
  </rdf:Description>
</rdf:RDF>

</model>