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Component: environment

Component: parameters

Component: membrane

\frac{d}{d time} (V_m) = \frac{I_stim - (I_Na + I_Ca + I_K + I_L + I_T + I_KCa)}{C_m}

Component: I_stim

H_0 = \{\begin{matrix} 0 if time < t_0 \\ 1 otherwise \end{matrix} H_1 = \{\begin{matrix} 0 if time < t_1 \\ 1 otherwise \end{matrix} I_stim = I_mag (H_0 - H_1)

Component: I_Na

I_Na = g_Na m^{3} h (V_m - E_Na)

Component: m

alpha_m = \frac{alpha_m_max (V_m - E_m)}{1 - (ⅇ^{\frac{E_m - V_m}{V_alpha_m}})} beta_m = beta_m_max ⅇ^{\frac{E_m - V_m}{V_beta_m}} \frac{d}{d time} (m) = alpha_m (1 - m) - (beta_m m)

Component: h

alpha_h = alpha_h_max ⅇ^{\frac{V_m - E_h}{V_alpha_h}} beta_h = \frac{beta_h_max}{1 + ⅇ^{\frac{E_h - V_m}{V_beta_h}}} \frac{d}{d time} (h) = alpha_h (1 - h) - (beta_h h)

Component: I_T

I_T = \frac{V_m - V_T}{R_s}

Component: V_T

\frac{d}{d time} (V_T) = \frac{V_m - V_T}{R_s C_t}

Component: I_KCa

I_KCa = g_KCa o w (V_m - E_K)

Component: o

alpha_Vm = \frac{a_bar}{1 + k_1 ⅇ^{\frac{(- 2) d_1 96.485 V_m}{RT c}}} beta_Vm = \frac{b_bar}{1 + \frac{c}{k_2 ⅇ^{\frac{(- 2) d_2 96.485 V_m}{RT}}}} tau_Vm = \frac{1}{alpha_Vm + beta_Vm} o_oinf = alpha_Vm tau_Vm \frac{d}{d time} (o) = \frac{o_oinf - o}{tau_Vm}

Component: w

w = \frac{c^{5}}{c^{5} + {kd}^{5}}

Component: calcium_handling

j_mem = (- alpha) I_Ca k_pmca c j_leak = p_leak (cer - c) j_serca = k_serca c j_er = j_leak - j_serca \frac{d}{d time} (c) = f_cyt (j_mem + j_er) \frac{d}{d time} (cer) = (- f_er) v_cytver j_er

Component: I_Ca

g_Ca = \frac{(- g_Ca0) V_m}{ⅇ^{0.117 V_m} - 1} I_Ca = g_Ca d^{2} (V_m - E_Ca)

Component: d

d_infinity = \frac{1}{1 + ⅇ^{\frac{- 24.6 - V_m}{11.3}}} tau_d = \frac{80 1}{\cosh ((- 0.031) (V_m + 37.1))} alpha_d = \frac{d_infinity}{tau_d} beta_d = \frac{1 - d_infinity}{tau_d} \frac{d}{d time} (d) = alpha_d (1 - d) - (beta_d d)

Component: I_L

I_L = g_Lmax (V_m - E_L)

Component: I_K

I_K = g_K n^{4} (V_m - E_K)

Component: n

alpha_n = \frac{alpha_n_max (V_m - E_n)}{1 - (ⅇ^{\frac{E_n - V_m}{V_alpha_n}})} beta_n = beta_n_max ⅇ^{\frac{E_n - V_m}{V_beta_n}} \frac{d}{d time} (n) = alpha_n (1 - n) - (beta_n n)

Source: Derived from workspace Wang, Lin, Lin, Wu, 2008 at changeset 8daae4dd06e9.

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Effect of riluzole on action potential in cultured human skeletal muscle cells