You are here: Home / Exposures / Koivumaki, Takalo, Korhonen, Tavi, Weckstrom, 2009 / Modelling Sarcoplasmic Reticulum Calcium APTase and its Regulation in Cardiac Myocytes

Model Mathematics

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Component: environment

Component: general_parameters

Component: serca_parameters

EC_50_fwd = (Kmf_PLBKO + Kmf_PLB PSR) (1 + 0.27 CaMKII_reg) EC_50_rev = Kmr_PLBKO - (Kmr_PLB PSR)

Component: transition_parameters

br_cyt_serca = 1000 br_serca_sr k_cyt_serca = br_cyt_serca (1 + 0.7 CaMKII_reg) k_serca_cyt = {EC_50_fwd}^{2} br_cyt_serca k_serca_sr = br_serca_sr (1 + 0.7 CaMKII_reg) k_sr_serca = \frac{br_serca_sr}{{EC_50_rev}^{2}}

Component: calcium_fluxes

J_cyt_serca = k_cyt_serca {Ca_cyt}^{2} (SERCA_TOT - Ca_serca) - (k_serca_cyt Ca_serca) J_serca_sr = k_serca_sr Ca_serca - (k_sr_serca {Ca_NSR}^{2} (SERCA_TOT - Ca_serca))

Component: calcium_bound_serca

\frac{d}{d time} (Ca_serca) = J_cyt_serca - J_serca_sr

Source: Derived from workspace Koivumaki,2009 at changeset 882b85019849.

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