<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : marwan_model_2003.xml
CREATED : 9th February 2004
LAST MODIFIED : 9th February 2004
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Marwan's 2003 mathematical model of sporulation control in Physarum polycephalum.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="marwan_2003_version01" name="marwan_2003_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Kinetic Model for the Sensory Control of Sporulation in Physarum polycephalum</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Complementation is the production of a wildtype phenotype when two recessive mutant alleles are combined in the same genotype. In fungi complementation can arise when two mutant cells form to produce a heterokaryon. In such heterokaryons two nuclear populations mix, providing the biochemical basis for the complementation effect.
</para>
<para>
In the Marwan 2003 publication described here, the author uses the photosensory control of sporulation in the protist <emphasis>Physarum polycephalum</emphasis> as an example of how complementation in a heterokaryon can create a wildtype phenotype. Marwan also investigates how such a process can depend on the time-dependent physiological state adopted after pathway activation by one of the mutant fusion partners.
</para>
<para>
The kinetic model of this process can be seen in <xref linkend="fig_reaction_diagram"/> below. Two inputs, light of the far-red wavelength and glucose, control the devlopmental switch network through formation of the sporulation signal <emphasis>S</emphasis>. Photoreceptor and glucose sensor dependent pathways are integrated by a mechanism which behaves like a logic AND gate. Transcription of gene S is repressed by the product of gene V, while the transcription of gene V is reiprocally repressed by the product of gene S.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Marwan 2003 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.genetics.org/cgi/content/abstract/164/1/105">Theory of Time-Resolved Somatic Complementation and Its Use to Explore the Sporulation Control Network in <emphasis>Physarum polycephalum</emphasis>
</ulink>, Wolfgang Marwan, 2003, <ulink url="http://www.genetics.org/">
<emphasis>Genetics</emphasis>
</ulink>, 164, 105-115. (<ulink url="http://www.genetics.org/cgi/content/full/164/1/105">Full text (HTML)</ulink> and <ulink url="http://www.genetics.org/cgi/reprint/164/1/105.pdf">PDF</ulink> versions of the article are available on the <emphasis>Genetics</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12750324&dopt=Abstract">PubMed ID: 12750324</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction diagram</title>
</objectinfo>
<imagedata fileref="marwan_2003.png"/>
</imageobject>
</mediaobject>
<caption>Schematic diagram of the kinetic model for the sensory control of sporulation in <emphasis>Physarum polycephalum</emphasis>.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<vCard:Given>Wolfgang</vCard:Given>
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<dcterms:W3CDTF>2004-02-09</dcterms:W3CDTF>
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<dcterms:W3CDTF>2003-05</dcterms:W3CDTF>
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<dc:title>Genetics</dc:title>
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<vCard:FN>Catherine Lloyd</vCard:FN>
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This is the CellML description of Marwan's 2003 mathematical model of sporulation control in Physarum polycephalum.
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<vCard:Orgname>The University of Auckland</vCard:Orgname>
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<vCard:Given>Catherine</vCard:Given>
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The University of Auckland, Bioengineering Institute
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Theory of Time-Resolved Somatic Complementation and Its Use to Explore the Sporulation Control Network in Physarum polycephalum
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<bqs:volume>164</bqs:volume>
<bqs:first_page>105</bqs:first_page>
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Marwan's 2003 mathematical model of sporulation control in Physarum polycephalum.
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