Model Mathematics

Component: environment

Component: membrane

dd time V =- i_Ca + i_K + i_K_Ca + i_K_ATP Cm

Component: calcium_current

i_Ca = g_Ca ⁢ m_infinity ⁢ V - V_Ca

Component: calcium_current_m_gate

m_infinity = 1.0 +ⅇ vm - V sm -1.0

Component: delayed_rectifier_potassium_current

i_K = g_K ⁢ n ⁢ V - V_K

Component: delayed_rectifier_potassium_current_n_gate

dd time n = n_infinity - n tau_n n_infinity = 1.0 +ⅇ vn - V sn -1.0

Component: calcium_dependent_potassium_current

i_K_Ca = g_K_Ca ⁢ omega ⁢ V - V_K

Component: calcium_dependent_potassium_current_omega_gate

omega = c 5.0 c 5.0 + kD 5.0

Component: nucleotide_sensitive_potassium_current

i_K_ATP = g_K_ATP ⁢ a ⁢ V - V_K

Component: nucleotide_sensitive_potassium_current_a_gate

dd time a = a_infinity - a tau_a a_infinity = 1.0 +ⅇ r - c sa -1.0

Component: cytosolic_free_calcium_concentration

dd time c = fcyt ⁢ Jmem + Jer

Component: ER_calcium_concentration

dd time c_er =- fer ⁢ Vcyt_Ver ⁢ Jer

Component: calcium_flux_through_the_membrane

Jmem =- alpha ⁢ i_Ca + kPMCA ⁢ c

Component: calcium_influx_into_the_ER

J_SERCA = kSERCA ⁢ c

Component: calcium_leak_out_of_the_ER

Jleak = pleak ⁢ c_er - c

Component: calcium_efflux_through_the_IP3R

JIP3 = O_infinity ⁢ c_er - c O_infinity=cd_act+c3⁢IP3d_IP3+IP33⁢cd_inact+c3⁢1

Component: net_calcium_efflux_out_of_the_ER

Jer = Jleak + JIP3 - J_SERCA