Model Mathematics

Component: environment

Component: PKACII_RyR

PKACII_RyR = PKACII_RyRtot + epsilon RyR PKACII_RyR Ks_RyR_PKAC

Component: PP1_RyR

PP1_RyR = PP1_RyRtot + epsilon RyRp PP1_RyR Ks_RyR_PP1

Component: PP2A_RyR

PP2A_RyR = PP2A_RyRtot + epsilon RyRp PP2A_RyR Ks_RyR_PP2A

Component: RyR

RyR = RyRtot + epsilon RyR PKACII_RyR Ks_RyR_PKAC

Component: RyRp

RyRp = RyRptot + epsilon RyRp PP1_RyR Ks_RyR_PP1 + epsilon RyRp PP2A_RyR Ks_RyR_PP2A

Component: RyRtot

RyRtot = RyRsum - RyRptot

Component: RyRptot

ddtimeRyRptot= kPKA_RyR epsilon RyR PKACII_RyR Ks_RyR_PKAC - kPP1_RyR epsilon RyRp PP1_RyR Ks_RyR_PP1 + kPP2A_RyR epsilon RyRp PP2A_RyR Ks_RyR_PP2A

Component: KMrel

KMrel = 1.64 1.0 + RyRptot RyRsum KMrel0

Component: TnI

TnI = TnItot - TnIp

Component: TnIp

ddtimeTnIp= kPKA_TnI PKAC TnI KM_PKA_TnI + TnIp - kPP2A_TnI PP2A TnIp KM_PP2A_TnI + TnIp

Component: KMTnC

KMTnC = 1.0 + 0.45 + TnIp TnItot KMTnC0

Component: kinetic_parameters