You are here: Home / Exposures / Mazhari, Greenstein, Winslow, Marban, Nuss, 2001 / Molecular Interactions Between Two Long-QT Syndrome Gene Products, HERG and KCNE2, Rationalized by In Vitro and In Silico Analysis

Model Mathematics

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Component: environment

Component: membrane

Component: C1

\frac{d}{d time} (C1) = beta_0 C2 - (alpha_0 C1)

Component: C2

\frac{d}{d time} (C2) = alpha_0 C1 + Kb C3 - (beta_0 C2 + Kf C2)

Component: C3

\frac{d}{d time} (C3) = beta_1 O + Kf C2 + psi I - (alpha_i3 C3 + alpha_1 C3 + Kb C3)

Component: O

\frac{d}{d time} (O) = alpha_1 C3 + beta_i I - (beta_1 O + alpha_i O)

Component: I

\frac{d}{d time} (I) = alpha_i O + alpha_i3 C3 - (beta_i I + psi I)

Component: reaction_constants

psi = \frac{beta_1 beta_i alpha_i3}{alpha_1 alpha_i} beta_0 = 0.0227 ⅇ^{(-0.0431) Vm} alpha_0 = 0.0069 ⅇ^{0.0272 Vm} beta_1 = 0.0009 ⅇ^{(-0.0269) Vm} alpha_1 = 0.0218 ⅇ^{0.0262 Vm} beta_i = 0.0059 ⅇ^{(-0.0443) Vm} alpha_i = 0.0622 ⅇ^{0.0120 Vm} alpha_i3 = (1.29E-5) ⅇ^{(2.71E-6) Vm}

Source: Derived from workspace Mazhari, Greenstein, Winslow, Marban, Nuss, 2001 at changeset 0140b8325d41.

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Molecular Interactions Between Two Long-QT Syndrome Gene Products, HERG and KCNE2, Rationalized by In Vitro and In Silico Analysis