Model Mathematics

Component: environment

Component: calcium_transient

dd time Ca_i = Ca_o + Ca_max - Ca_o time tau_Ca 1.0 - time tau_Ca

Component: TnC_Ca_binding_kinetics

dd time Ca_b = rho_0 Ca_i Ca_b_max - Ca_b - rho_1 Ca_b 1.0 - T lambda To

Component: thin_filament_kinetics

dd time z = alpha_0 Ca_b C_50 n 1.0 - z - z To = T_ref 1.0 + beta_0 lambda - 1.0 z n = n_ref 1.0 + beta_1 lambda - 1.0 pC_50 = pC_50_ref 1.0 + beta_2 lambda - 1.0

Component: crossbridge_kinetics

dlambda_dt = alpha_1 A1 T To - 1.0 T To + a T = To 1.0 + a Q 1.0 - Q Q = A1 - alpha_1 time - tau dlambda_dt tau + A2 - alpha_2 time - tau dlambda_dt tau + A3 - alpha_3 time - tau dlambda_dt tau