Model Mathematics

Component: environment

Component: calcium_transient

dd time Ca_i = Ca_o + Ca_max - Ca_o ⁢ time tau_Ca ⁢ⅇ 1.0 - time tau_Ca

Component: TnC_Ca_binding_kinetics

dd time Ca_b = rho_0 ⁢ Ca_i ⁢ Ca_b_max - Ca_b - rho_1 ⁢ Ca_b ⁢ 1.0 - T lambda ⁢ To

Component: thin_filament_kinetics

dd time z = alpha_0 ⁢ Ca_b C_50 n ⁢ 1.0 - z - z To = T_ref ⁢ 1.0 + beta_0 ⁢ lambda - 1.0 ⁢ z n = n_ref ⁢ 1.0 + beta_1 ⁢ lambda - 1.0 pC_50 = pC_50_ref ⁢ 1.0 + beta_2 ⁢ lambda - 1.0

Component: crossbridge_kinetics

dlambda_dt = alpha_1 A1 ⁢ T To - 1.0 T To + a T = To ⁢ 1.0 + a ⁢ Q 1.0 - Q Q = A1 ⁢ⅇ- alpha_1 ⁢ time - tau ⁢ dlambda_dt ⁢ tau + A2 ⁢ⅇ- alpha_2 ⁢ time - tau ⁢ dlambda_dt ⁢ tau + A3 ⁢ⅇ- alpha_3 ⁢ time - tau ⁢ dlambda_dt ⁢ tau