You are here: Home / Exposures / Dawson, Lea, Irvine, 2003 / Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores

Model Mathematics

Component based math viewer is available

Component: environment

Component: R

\frac{d}{d time} (R) = V1 + V4 + V2

Component: R__

\frac{d}{d time} (R__) = V4 + V5

Component: I

\frac{d}{d time} (I) = V2 + V6

Component: O1

\frac{d}{d time} (O1) = V2 + V7 + V3

Component: O2

\frac{d}{d time} (O2) = V3

Component: R_

\frac{d}{d time} (R_) = V1 + V5 + V6

Component: C1

\frac{d}{d time} (C1) = V6 + V7

Component: Ca_ER

\frac{d}{d time} (Ca_ER) = V8 + V9

Component: Ca_cyt

\frac{d}{d time} (Ca_cyt) = V10

Component: Ca_L

\frac{d}{d time} (Ca_L) = V4 + V5 + V3 + V10 + V8 + V9

Component: V1

V1 = k1_R_- (k1 R)

Component: V2

V2 = k2_O1 - (k2 R I)

Component: V3

V3 = k3_O2 - (k3 O1 Ca_L)

Component: V4

V4 = k4_R__- (k4 R Ca_L)

Component: V5

V5 = k5_R__- (k5 R_Ca_L)

Component: V6

V6 = k6_C1 - (k6 R_I)

Component: V7

V7 = k7_C1 - (k7 O1)

Component: V8

V8 = k8 Ca_ER

Component: V9

V9 = k9 Ca_ER

Component: V10

V10 = k10 Ca_L

Source: Derived from workspace Dawson, Lea, Irvine, 2003 at changeset b690a07a26b8.

Collaboration: To begin collaborating on this work, please use your git client and issue this command:

Downloads

Views Available

Tools

License: This work is licensed under a Creative Commons Attribution 3.0 Unported License.

Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores