You are here: Home / Exposures / Thomsen, Neubig, 1989 / Rapid kinetics of alpha 2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step

Model Mathematics

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Component: environment

Component: R

\frac{d}{d time} (R) = (- (k1 D R)) + k1_DR \frac{d}{d time} (D) = (- (k1 D R)) + k1_DR

Component: DR

\frac{d}{d time} (DR) = (k1 D R - (k1_DR) - (k2 DR G_GDP)) + k2_DRG_GDP + k5 DRG_GTP

Component: DRG_GDP

\frac{d}{d time} (DRG_GDP) = k2 DR G_GDP + k3_DRG GDP - ((k2_+ k3) DRG_GDP)

Component: DRG

\frac{d}{d time} (DRG) = k3 DRG_GDP + k4_DRG_GTP - (k3_GTP + k4 GTP DRG)

Component: DRG_GTP

\frac{d}{d time} (DRG_GTP) = k4 DRG GTP - ((k4_+ k5) DRG_GTP)

Component: Gstar_GTP

\frac{d}{d time} (Gstar_GTP) = k5 DRG_GTP - (k6 Gstar_GTP)

Component: G_GDP

\frac{d}{d time} (G_GDP) = k6 Gstar_GTP - (k2 G_GDP)

Component: rate_variables

Component: GXP

Source: Derived from workspace Thomsen, Neubig, 1989 at changeset c314203710fa.

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Rapid kinetics of alpha 2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step