Rendering of the source text

<?xml version="1.0"?>
<!--  FILE :  noble_model_1998.xml

CREATED :  18th December 2001

LAST MODIFIED : 22nd July 2002

AUTHOR :  Catherine Lloyd
          Department of Engineering Science
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of Noble's 1998 improved
guinea-pig ventricular cell model.

CHANGES:  
  04/01/2002 - CML - Altered some of the connections.
  21/01/2002 - AAC - Updated metadata to conform to the 16/1/02 CellML Metadata
                     1.0 Specification.
  25/02/2002 - CML - Corrected i_K1 and i_K_ACh calculations.
  26/02/2002 - CML - Corrected several more equations.
  01/03/2002 - CML - Corrected units.
  06/05/2002 - CML - Added some initial values.  Removed the blocked h_gate 
                     component from the fast sodium current as it belongs to a
                     separate model which considers the effect of drugs.
  22/07/2002 - CML - Added more metadata.
  08/02/2003 - DPN - Added encapsulation hierarchy for transient_outward_current.
  04/11/2007 - PJN - Units checked, curated
-->
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes</title>
  <author>
    <firstname>Penny</firstname>
          <surname>Noble</surname>
    <affiliation>
      <shortaffil>Oxford University</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
This version has been curated and unit checked by Penny Noble and is known to run into COR and PCEnv. This variant is parameterised for the BASIC model, excluding acetylcholine dependent modulation and electromechanical processes. This model is also associated with a PCEnv session file.
    </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>ABSTRACT: The guinea-pig ventricular cell model, originally developed by Noble et al in 1991, has been greatly extended to include accumulation and depletion of calcium in a diadic space between the sarcolemma and the sarcoplasmic reticulum where, according to contempory understanding, the majority of calcium-induced calcium release is triggered. The calcium in this space is also assumed to play the major role in calcium-induced inactivation of the calcium current. Delayed potassium current equations have been developed to include the rapid (IKr) and slow (IKs) components of the delayed rectifier current based on the data of of Heath and Terrar, along with data from Sanguinetti and Jurkiewicz. Length- and tension-dependent changes in mechanical and electrophysiological processes have been incorporated as described recently by Kohl et al. Drug receptor interactions have started to be developed, using the sodium channel as the first target. The new model has been tested against experimental data on action potential clamp, and on force-interval and duration-interval relations; it has been found to reliably reproduce experimental observations.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes, Denis Noble, Anthony Varghese, Peter Kohl and Penelope Noble, 1998, <emphasis>Can J Cardiol</emphasis>, 14, 123-134.  <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/9487284">PubMed ID: 9487284</ulink>
</para>

<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of Noble'98 model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="noble_1998a.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Noble'98 model.</caption>
</informalfigure>

</sect1>
</article>
</documentation>

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   </component>
   <component name="rapid_delayed_rectifier_potassium_current_xr2_gate">
      <variable initial_value="2e-7" name="xr2" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="alpha_xr2" units="per_second"/>
      <variable name="beta_xr2" units="per_second"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_xr2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">50</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xr2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.4</cn>
               <apply>
                  <exp/>
                  <apply>
                     <minus/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_xr2</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>xr2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_xr2</ci>
                  <ci>xr2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current">
      <variable cmeta:id="slow_delayed_rectifier_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="nanoA"/>
      <variable initial_value="0.0026" name="g_Ks" units="microS"/>
      <variable name="E_Ks" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="xs" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <apply>
                  <power/>
                  <ci>xs</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs_gate">
      <variable initial_value="0.001302" name="xs" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="alpha_xs" units="per_second"/>
      <variable name="beta_xs" units="per_second"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_xs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">14</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xs</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_xs</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>xs</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_xs</ci>
                  <ci>xs</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current">
      <variable cmeta:id="fast_sodium_current_i_Na" name="i_Na" public_interface="out" units="nanoA"/>
      <variable initial_value="2.5" name="g_Na" units="microS"/>
      <variable name="E_mh" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <times/>
               <ci>g_Na</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_mh</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_m_gate">
      <variable initial_value="0.0016203" name="m" public_interface="out" units="dimensionless"/>
      <variable name="alpha_m" units="per_second"/>
      <variable name="beta_m" units="per_second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable initial_value="1e-5" name="delta_m" units="millivolt"/>
      <variable name="E0_m" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_m</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">41</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2000</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <ci>E0_m</ci>
                     </apply>
                     <ci>delta_m</ci>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">200</cn>
                        <ci>E0_m</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <ci>E0_m</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">8000</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.056</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">66</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_h_gate">
      <variable initial_value="0.9944036" name="h" public_interface="out" units="dimensionless"/>
      <variable name="alpha_h" units="per_second"/>
      <variable name="beta_h" units="per_second"/>
      <variable initial_value="0" name="shift_h" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">20</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.125</cn>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
                        </apply>
                        <ci>shift_h</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2000</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">320</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                           </apply>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
                              </apply>
                              <ci>shift_h</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_h</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>h</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_h</ci>
                  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="persistent_sodium_current">
      <variable cmeta:id="persistent_sodium_current_i_p_Na" name="i_p_Na" public_interface="out" units="nanoA"/>
      <variable initial_value="0.004" name="g_pna" units="microS"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Na</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>g_pna</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">52</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable cmeta:id="sodium_background_current_i_b_Na" name="i_b_Na" public_interface="out" units="nanoA"/>
      <variable initial_value="0.0006" name="g_bna" units="microS"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_b_Na</ci>
            <apply>
               <times/>
               <ci>g_bna</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable name="i_Ca_L_Ca_cyt" public_interface="out" units="nanoA"/>
      <variable name="i_Ca_L_K_cyt" public_interface="out" units="nanoA"/>
      <variable name="i_Ca_L_Na_cyt" public_interface="out" units="nanoA"/>
      <variable name="i_Ca_L_Ca_ds" public_interface="out" units="nanoA"/>
      <variable name="i_Ca_L_K_ds" public_interface="out" units="nanoA"/>
      <variable name="i_Ca_L_Na_ds" public_interface="out" units="nanoA"/>
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="nanoA"/>
      <variable initial_value="0.1" name="P_Ca_L" units="nanoA_per_millimolar"/>
      <variable initial_value="0.002" name="P_CaK" units="dimensionless"/>
      <variable initial_value="0.01" name="P_CaNa" units="dimensionless"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="Ca_ds" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="K_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="d" private_interface="in" units="dimensionless"/>
      <variable name="f" private_interface="in" units="dimensionless"/>
      <variable name="f2" private_interface="in" units="dimensionless"/>
      <variable name="f2ds" private_interface="in" units="dimensionless"/>
      <variable initial_value="100000" name="Km_f2" private_interface="out" units="millimolar"/>
      <variable initial_value="0.001" name="Km_f2ds" private_interface="out" units="millimolar"/>
      <variable initial_value="20" name="R_decay" private_interface="out" public_interface="out" units="per_second"/>
      <variable initial_value="1" name="FrICa" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_L_Ca_cyt</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>FrICa</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        <ci>P_Ca_L</ci>
                        <ci>d</ci>
                        <ci>f</ci>
                        <ci>f2</ci>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Ca_i</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Ca_o</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_K_cyt</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>FrICa</ci>
                        </apply>
                        <ci>P_CaK</ci>
                        <ci>P_Ca_L</ci>
                        <ci>d</ci>
                        <ci>f</ci>
                        <ci>f2</ci>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>K_i</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>K_o</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_Na_cyt</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>FrICa</ci>
                        </apply>
                        <ci>P_CaNa</ci>
                        <ci>P_Ca_L</ci>
                        <ci>d</ci>
                        <ci>f</ci>
                        <ci>f2</ci>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Na_i</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Na_o</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_Ca_ds</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>FrICa</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        <ci>P_Ca_L</ci>
                        <ci>d</ci>
                        <ci>f</ci>
                        <ci>f2ds</ci>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Ca_i</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Ca_o</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_K_ds</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>FrICa</ci>
                        <ci>P_CaK</ci>
                        <ci>P_Ca_L</ci>
                        <ci>d</ci>
                        <ci>f</ci>
                        <ci>f2ds</ci>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>K_i</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>K_o</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_Na_ds</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>FrICa</ci>
                        <ci>P_CaNa</ci>
                        <ci>P_Ca_L</ci>
                        <ci>d</ci>
                        <ci>f</ci>
                        <ci>f2ds</ci>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Na_i</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Na_o</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                                 </apply>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <plus/>
               <ci>i_Ca_L_Ca_cyt</ci>
               <ci>i_Ca_L_K_cyt</ci>
               <ci>i_Ca_L_Na_cyt</ci>
               <ci>i_Ca_L_Ca_ds</ci>
               <ci>i_Ca_L_K_ds</ci>
               <ci>i_Ca_L_Na_ds</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_d_gate">
      <variable initial_value="0" name="d" public_interface="out" units="dimensionless"/>
      <variable name="alpha_d" units="per_second"/>
      <variable name="beta_d" units="per_second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="E0_d" units="millivolt"/>
      <variable initial_value="3" name="speed_d" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_d</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>V</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">24</cn>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <ci>E0_d</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.0001</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">30</cn>
                        <ci>E0_d</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>E0_d</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <ci>E0_d</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.0001</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">12</cn>
                        <ci>E0_d</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <ci>E0_d</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <times/>
               <ci>speed_d</ci>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>alpha_d</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>d</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_d</ci>
                     <ci>d</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_gate">
      <variable initial_value="1" name="f" public_interface="out" units="dimensionless"/>
      <variable name="alpha_f" units="per_second"/>
      <variable name="beta_f" units="per_second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable initial_value="0.3" name="speed_f" units="dimensionless"/>
      <variable initial_value="0.0001" name="delta_f" units="millivolt"/>
      <variable name="E0_f" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_f</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">25</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <ci>E0_f</ci>
                     </apply>
                     <ci>delta_f</ci>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">6.25</cn>
                        <ci>E0_f</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <ci>E0_f</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">12</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <times/>
               <ci>speed_f</ci>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>alpha_f</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>f</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_f</ci>
                     <ci>f</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f2_gate">
      <variable initial_value="0.9349197" name="f2" public_interface="out" units="dimensionless"/>
      <variable name="Km_f2" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f2</ci>
            </apply>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <ci>Ca_i</ci>
                        <apply>
                           <plus/>
                           <ci>Km_f2</ci>
                           <ci>Ca_i</ci>
                        </apply>
                     </apply>
                     <ci>f2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f2ds_gate">
      <variable initial_value="0.9651958" name="f2ds" public_interface="out" units="dimensionless"/>
      <variable name="Km_f2ds" public_interface="in" units="millimolar"/>
      <variable name="R_decay" public_interface="in" units="per_second"/>
      <variable name="Ca_ds" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f2ds</ci>
            </apply>
            <apply>
               <times/>
               <ci>R_decay</ci>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <ci>Ca_ds</ci>
                        <apply>
                           <plus/>
                           <ci>Km_f2ds</ci>
                           <ci>Ca_ds</ci>
                        </apply>
                     </apply>
                     <ci>f2ds</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable cmeta:id="calcium_background_current_i_b_Ca" name="i_b_Ca" public_interface="out" units="nanoA"/>
      <variable initial_value="0.00025" name="g_bca" units="microS"/>
      <variable name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_b_Ca</ci>
            <apply>
               <times/>
               <ci>g_bca</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current">
      <variable cmeta:id="transient_outward_current_i_to" name="i_to" public_interface="out" units="nanoA"/>
      <variable initial_value="0.005" name="g_to" units="microS"/>
      <variable initial_value="0" name="g_tos" units="dimensionless"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="s" private_interface="in" units="dimensionless"/>
      <variable name="r" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <apply>
                  <plus/>
                  <ci>g_tos</ci>
                  <apply>
                     <times/>
                     <ci>s</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>g_tos</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>r</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_s_gate">
      <variable initial_value="0.9948645" name="s" public_interface="out" units="dimensionless"/>
      <variable name="alpha_s" units="per_second"/>
      <variable name="beta_s" units="per_second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_s</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.033</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_s</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">33</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.125</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>s</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_s</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>s</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_s</ci>
                  <ci>s</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_r_gate">
      <variable initial_value="0" name="r" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>r</ci>
            </apply>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">333</cn>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <ci>r</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="nanoA"/>
      <variable initial_value="0.7" name="i_NaK_max" units="nanoA"/>
      <variable initial_value="1" name="K_mK" units="millimolar"/>
      <variable initial_value="40" name="K_mNa" units="millimolar"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_NaK_max</ci>
                        <ci>K_o</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>K_mK</ci>
                        <ci>K_o</ci>
                     </apply>
                  </apply>
                  <ci>Na_i</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_mNa</ci>
                  <ci>Na_i</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_calcium_exchanger">
      <variable cmeta:id="sodium_calcium_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="nanoA"/>
      <variable name="i_NaCa_cyt" public_interface="out" units="nanoA"/>
      <variable name="i_NaCa_ds" public_interface="out" units="nanoA"/>
      <variable initial_value="0.0005" name="k_NaCa" units="nanoA"/>
      <variable initial_value="3" name="n_NaCa" units="dimensionless"/>
      <variable initial_value="0" name="d_NaCa" units="dimensionless"/>
      <variable initial_value="0.5" name="gamma" units="dimensionless"/>
      <variable initial_value="0.001" name="FRiNaCa" units="dimensionless"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_ds" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa_cyt</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>FRiNaCa</ci>
                  </apply>
                  <ci>k_NaCa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>gamma</ci>
                                 <apply>
                                    <minus/>
                                    <ci>n_NaCa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_i</ci>
                           <ci>n_NaCa</ci>
                        </apply>
                        <ci>Ca_o</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>gamma</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <ci>n_NaCa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_o</ci>
                           <ci>n_NaCa</ci>
                        </apply>
                        <ci>Ca_i</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                     <apply>
                        <times/>
                        <ci>d_NaCa</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>Ca_i</ci>
                              <apply>
                                 <power/>
                                 <ci>Na_o</ci>
                                 <ci>n_NaCa</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>Ca_o</ci>
                              <apply>
                                 <power/>
                                 <ci>Na_i</ci>
                                 <ci>n_NaCa</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Ca_i</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0069</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaCa_ds</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>FRiNaCa</ci>
                  <ci>k_NaCa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>gamma</ci>
                                 <apply>
                                    <minus/>
                                    <ci>n_NaCa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_i</ci>
                           <ci>n_NaCa</ci>
                        </apply>
                        <ci>Ca_o</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>gamma</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <ci>n_NaCa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_o</ci>
                           <ci>n_NaCa</ci>
                        </apply>
                        <ci>Ca_ds</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                     <apply>
                        <times/>
                        <ci>d_NaCa</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>Ca_ds</ci>
                              <apply>
                                 <power/>
                                 <ci>Na_o</ci>
                                 <ci>n_NaCa</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>Ca_o</ci>
                              <apply>
                                 <power/>
                                 <ci>Na_i</ci>
                                 <ci>n_NaCa</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Ca_ds</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0069</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <plus/>
               <ci>i_NaCa_cyt</ci>
               <ci>i_NaCa_ds</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sarcoplasmic_reticulum_calcium_pump">
      <variable cmeta:id="sarcoplasmic_reticulum_calcium_pump_i_up" name="i_up" public_interface="out" units="millimolar_per_second"/>
      <variable name="K_1" units="dimensionless"/>
      <variable name="K_2" units="millimolar"/>
      <variable initial_value="0.0003" name="K_cyca" units="millimolar"/>
      <variable initial_value="0.4" name="K_xcs" units="dimensionless"/>
      <variable initial_value="0.5" name="K_srca" units="millimolar"/>
      <variable initial_value="0.4" name="alpha_up" units="millimolar_per_second"/>
      <variable initial_value="0.03" name="beta_up" units="millimolar_per_second"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_up" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>K_1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>K_cyca</ci>
                  <ci>K_xcs</ci>
               </apply>
               <ci>K_srca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K_2</ci>
            <apply>
               <plus/>
               <ci>Ca_i</ci>
               <apply>
                  <times/>
                  <ci>Ca_up</ci>
                  <ci>K_1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>K_cyca</ci>
                  <ci>K_xcs</ci>
               </apply>
               <ci>K_cyca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>Ca_i</ci>
                     <ci>K_2</ci>
                  </apply>
                  <ci>alpha_up</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Ca_up</ci>
                        <ci>K_1</ci>
                     </apply>
                     <ci>K_2</ci>
                  </apply>
                  <ci>beta_up</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_translocation">
      <variable cmeta:id="calcium_translocation_i_trans" name="i_trans" public_interface="out" units="millimolar_per_second"/>
      <variable name="Ca_rel" public_interface="in" units="millimolar"/>
      <variable name="Ca_up" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_trans</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">50</cn>
               <apply>
                  <minus/>
                  <ci>Ca_up</ci>
                  <ci>Ca_rel</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_release">
      <variable cmeta:id="calcium_release_i_rel" name="i_rel" public_interface="out" units="millimolar_per_second"/>
      <variable name="VoltDep" units="dimensionless"/>
      <variable name="RegBindSite" units="dimensionless"/>
      <variable name="CaiReg" units="dimensionless"/>
      <variable name="CadsReg" units="dimensionless"/>
      <variable name="ActRate" units="per_second"/>
      <variable name="InactRate" units="per_second"/>
      <variable initial_value="0.05" name="K_leak_rate" units="per_second"/>
      <variable initial_value="250" name="K_m_rel" units="per_second"/>
      <variable initial_value="0.0005" name="K_m_Ca_cyt" units="millimolar"/>
      <variable initial_value="0.01" name="K_m_Ca_ds" units="millimolar"/>
      <variable name="PrecFrac" units="dimensionless"/>
      <variable initial_value="0.0042614" name="ActFrac" units="dimensionless"/>
      <variable initial_value="0.4068154" name="ProdFrac" units="dimensionless"/>
      <variable name="SpeedRel" units="dimensionless"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_ds" public_interface="in" units="millimolar"/>
      <variable name="Ca_rel" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>VoltDep</ci>
            <apply>
               <exp/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08</cn>
                  <apply>
                     <minus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CaiReg</ci>
            <apply>
               <divide/>
               <ci>Ca_i</ci>
               <apply>
                  <plus/>
                  <ci>Ca_i</ci>
                  <ci>K_m_Ca_cyt</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CadsReg</ci>
            <apply>
               <divide/>
               <ci>Ca_ds</ci>
               <apply>
                  <plus/>
                  <ci>Ca_ds</ci>
                  <ci>K_m_Ca_ds</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>RegBindSite</ci>
            <apply>
               <plus/>
               <ci>CaiReg</ci>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>CaiReg</ci>
                  </apply>
                  <ci>CadsReg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ActRate</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0</cn>
                  <ci>VoltDep</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn>
                  <apply>
                     <power/>
                     <ci>RegBindSite</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>InactRate</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">60</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn>
                  <apply>
                     <power/>
                     <ci>RegBindSite</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>SpeedRel</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>PrecFrac</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>ActFrac</ci>
               </apply>
               <ci>ProdFrac</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ActFrac</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>PrecFrac</ci>
                  <ci>SpeedRel</ci>
                  <ci>ActRate</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>ActFrac</ci>
                  <ci>SpeedRel</ci>
                  <ci>InactRate</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ProdFrac</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>ActFrac</ci>
                  <ci>SpeedRel</ci>
                  <ci>InactRate</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>SpeedRel</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
                  <ci>ProdFrac</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_rel</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>ActFrac</ci>
                           <apply>
                              <plus/>
                              <ci>ActFrac</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>K_m_rel</ci>
                  </apply>
                  <ci>K_leak_rate</ci>
               </apply>
               <ci>Ca_rel</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="extracellular_sodium_concentration">
      <variable initial_value="140" name="Na_o" public_interface="out" units="millimolar"/>
   </component>
   <component name="intracellular_sodium_concentration">
      <variable initial_value="7.3321223" name="Na_i" public_interface="out" units="millimolar"/>
      <variable name="V_i" public_interface="in" units="micrometre3"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="i_Na" public_interface="in" units="nanoA"/>
      <variable name="i_b_Na" public_interface="in" units="nanoA"/>
      <variable name="i_p_Na" public_interface="in" units="nanoA"/>
      <variable name="i_Ca_L_Na_cyt" public_interface="in" units="nanoA"/>
      <variable name="i_Ca_L_Na_ds" public_interface="in" units="nanoA"/>
      <variable name="i_NaK" public_interface="in" units="nanoA"/>
      <variable name="i_NaCa_cyt" public_interface="in" units="nanoA"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_i</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                     <ci>V_i</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <ci>i_Na</ci>
                  <ci>i_p_Na</ci>
                  <ci>i_b_Na</ci>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>i_NaK</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>i_NaCa_cyt</ci>
                  </apply>
                  <ci>i_Ca_L_Na_cyt</ci>
                  <ci>i_Ca_L_Na_ds</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="extracellular_calcium_concentration">
      <variable initial_value="2" name="Ca_o" public_interface="out" units="millimolar"/>
   </component>
   <component name="extracellular_potassium_concentration">
      <variable initial_value="4" name="K_o" public_interface="out" units="millimolar"/>
   </component>
   <component name="intracellular_potassium_concentration">
      <variable initial_value="136.5644281" name="K_i" public_interface="out" units="millimolar"/>
      <variable name="V_i" public_interface="in" units="micrometre3"/>
      <variable name="i_K1" public_interface="in" units="nanoA"/>
      <variable name="i_Kr" public_interface="in" units="nanoA"/>
      <variable name="i_Ks" public_interface="in" units="nanoA"/>
      <variable name="i_Ca_L_K_cyt" public_interface="in" units="nanoA"/>
      <variable name="i_Ca_L_K_ds" public_interface="in" units="nanoA"/>
      <variable name="i_to" public_interface="in" units="nanoA"/>
      <variable name="i_NaK" public_interface="in" units="nanoA"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>K_i</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                     <ci>V_i</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>i_K1</ci>
                     <ci>i_Kr</ci>
                     <ci>i_Ks</ci>
                     <ci>i_Ca_L_K_cyt</ci>
                     <ci>i_Ca_L_K_ds</ci>
                     <ci>i_to</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>i_NaK</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="intracellular_calcium_concentration">
      <variable cmeta:id="intracellular_calcium_concentration_Ca_i" initial_value="1.4e-5" name="Ca_i" public_interface="out" units="millimolar"/>
      <variable initial_value="1.88e-5" name="Ca_ds" public_interface="out" units="millimolar"/>
      <variable initial_value="0.4531889" name="Ca_up" public_interface="out" units="millimolar"/>
      <variable initial_value="0.4481927" name="Ca_rel" public_interface="out" units="millimolar"/>
      <variable initial_value="0.0005555" name="Ca_Calmod" units="millimolar"/>
      <variable initial_value="0.0003542" name="Ca_Trop" units="millimolar"/>
      <variable initial_value="0.02" name="Calmod" units="millimolar"/>
      <variable initial_value="0.05" name="Trop" units="millimolar"/>
      <variable initial_value="100000" name="alpha_Calmod" units="per_millimolar_second"/>
      <variable initial_value="50" name="beta_Calmod" units="per_second"/>
      <variable initial_value="100000" name="alpha_Trop" units="per_millimolar_second"/>
      <variable initial_value="200" name="beta_Trop" units="per_second"/>
      <variable initial_value="0.012" name="radius" units="micrometre"/>
      <variable initial_value="0.074" name="length" units="micrometre"/>
      <variable name="V_i" public_interface="out" units="micrometre3"/>
      <variable name="V_Cell" units="micrometre3"/>
      <variable name="V_i_ratio" units="dimensionless"/>
      <variable initial_value="0.1" name="V_ds_ratio" units="dimensionless"/>
      <variable initial_value="0.1" name="V_rel_ratio" units="dimensionless"/>
      <variable initial_value="0.4" name="V_e_ratio" units="dimensionless"/>
      <variable initial_value="0.01" name="V_up_ratio" units="dimensionless"/>
      <variable initial_value="10" name="Kdecay" units="per_second"/>
      <variable name="i_up" public_interface="in" units="millimolar_per_second"/>
      <variable name="i_trans" public_interface="in" units="millimolar_per_second"/>
      <variable name="i_rel" public_interface="in" units="millimolar_per_second"/>
      <variable name="i_NaCa_cyt" public_interface="in" units="nanoA"/>
      <variable name="i_NaCa_ds" public_interface="in" units="nanoA"/>
      <variable name="i_Ca_L_Ca_cyt" public_interface="in" units="nanoA"/>
      <variable name="i_Ca_L_Ca_ds" public_interface="in" units="nanoA"/>
      <variable name="i_b_Ca" public_interface="in" units="nanoA"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_Cell</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.141592654</cn>
               <apply>
                  <power/>
                  <ci>radius</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <ci>length</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_i_ratio</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>V_e_ratio</ci>
                  </apply>
                  <ci>V_up_ratio</ci>
               </apply>
               <ci>V_rel_ratio</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_i</ci>
            <apply>
               <times/>
               <ci>V_Cell</ci>
               <ci>V_i_ratio</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_i</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                                 <ci>V_i</ci>
                                 <ci>F</ci>
                              </apply>
                           </apply>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>i_Ca_L_Ca_cyt</ci>
                                    <ci>i_b_Ca</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    <ci>i_NaCa_cyt</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>i_NaCa_ds</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Ca_ds</ci>
                           <ci>V_ds_ratio</ci>
                           <ci>Kdecay</ci>
                        </apply>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>i_rel</ci>
                              <ci>V_rel_ratio</ci>
                           </apply>
                           <ci>V_i_ratio</ci>
                        </apply>
                     </apply>
                     <apply>
                        <diff/>
                        <bvar>
                           <ci>time</ci>
                        </bvar>
                        <ci>Ca_Calmod</ci>
                     </apply>
                  </apply>
                  <apply>
                     <diff/>
                     <bvar>
                        <ci>time</ci>
                     </bvar>
                     <ci>Ca_Trop</ci>
                  </apply>
               </apply>
               <ci>i_up</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_ds</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
                     </apply>
                     <ci>i_Ca_L_Ca_ds</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                     <ci>V_ds_ratio</ci>
                     <ci>V_i</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>Ca_ds</ci>
                  <ci>Kdecay</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_up</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>V_i_ratio</ci>
                     <ci>V_up_ratio</ci>
                  </apply>
                  <ci>i_up</ci>
               </apply>
               <ci>i_trans</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_rel</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>V_up_ratio</ci>
                     <ci>V_rel_ratio</ci>
                  </apply>
                  <ci>i_trans</ci>
               </apply>
               <ci>i_rel</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_Calmod</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_Calmod</ci>
                  <ci>Ca_i</ci>
                  <apply>
                     <minus/>
                     <ci>Calmod</ci>
                     <ci>Ca_Calmod</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_Calmod</ci>
                  <ci>Ca_Calmod</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_Trop</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_Trop</ci>
                  <ci>Ca_i</ci>
                  <apply>
                     <minus/>
                     <ci>Trop</ci>
                     <ci>Ca_Trop</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_Trop</ci>
                  <ci>Ca_Trop</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="membrane">
         <component_ref component="fast_sodium_current">
            <component_ref component="fast_sodium_current_m_gate"/>
            <component_ref component="fast_sodium_current_h_gate"/>
         </component_ref>
         <component_ref component="L_type_Ca_channel">
            <component_ref component="L_type_Ca_channel_d_gate"/>
            <component_ref component="L_type_Ca_channel_f_gate"/>
            <component_ref component="L_type_Ca_channel_f2_gate"/>
            <component_ref component="L_type_Ca_channel_f2ds_gate"/>
         </component_ref>
         <component_ref component="rapid_delayed_rectifier_potassium_current">
            <component_ref component="rapid_delayed_rectifier_potassium_current_xr1_gate"/>
            <component_ref component="rapid_delayed_rectifier_potassium_current_xr2_gate"/>
         </component_ref>
         <component_ref component="slow_delayed_rectifier_potassium_current">
            <component_ref component="slow_delayed_rectifier_potassium_current_xs_gate"/>
         </component_ref>
         <component_ref component="time_independent_potassium_current"/>
         <component_ref component="persistent_sodium_current"/>
         <component_ref component="sodium_background_current"/>
         <component_ref component="calcium_background_current"/>
         <component_ref component="transient_outward_current">
            <component_ref component="transient_outward_current_s_gate"/>
            <component_ref component="transient_outward_current_r_gate"/>
         </component_ref>
         <component_ref component="sodium_potassium_pump"/>
         <component_ref component="sodium_calcium_exchanger"/>
         <component_ref component="sarcoplasmic_reticulum_calcium_pump"/>
         <component_ref component="calcium_translocation"/>
         <component_ref component="calcium_release"/>
         <component_ref component="extracellular_sodium_concentration"/>
         <component_ref component="intracellular_sodium_concentration"/>
         <component_ref component="extracellular_potassium_concentration"/>
         <component_ref component="intracellular_potassium_concentration"/>
         <component_ref component="extracellular_calcium_concentration"/>
         <component_ref component="intracellular_calcium_concentration"/>
         <component_ref component="reversal_potentials"/>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
         <component_ref component="L_type_Ca_channel_f2_gate"/>
         <component_ref component="L_type_Ca_channel_f2ds_gate"/>
      </component_ref>
      <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_s_gate"/>
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      <map_components component_1="reversal_potentials" component_2="time_independent_potassium_current"/>
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      <map_components component_1="reversal_potentials" component_2="rapid_delayed_rectifier_potassium_current"/>
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      <map_variables variable_1="E_mh" variable_2="E_mh"/>
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      <map_variables variable_1="Na_i" variable_2="Na_i"/>
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      <map_variables variable_1="i_Ca_L_Na_ds" variable_2="i_Ca_L_Na_ds"/>
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    <rdf:value>This file is a CellML description of Noble, Carghese, Kohl and Noble's 1998 extension of their 1991 guinea pig ventricular cell model. This model incorporates a diadic space, IKr and IKs currents, and length and tension dependent processes. Variant 1 is parameterised for the 'basic' model. 
To simulate multiple action potentials with this model the following integrator parameters must be used: max step size must be 0.001 or less, max point density must be 10,000 or more.</rdf:value>
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    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.</dc:title>
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    <rdf:value>Penny Noble was informed by a community member that INaCads was not included in the dCads/dt ODE and hence the system was out of balance. This has been fixed in version 07. An alteration was also made to the model to remove two differential expressions in the intracellular_calcium concentration component to allow PCEnv 0.2 to run the model.</rdf:value>
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    <rdf:value>Units checked, curated.</rdf:value>
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        <rdf:li>electrophysiology</rdf:li>
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    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes (Basic Model)</dc:title>
	<dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/">Department of Physiology, Anatomy &amp; Genetics, University of Oxford</dc:publisher>
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    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-12-04T15:09:12+13:00</dcterms:W3CDTF>
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    <rdf:value>This version was created by Penny Noble and is known to read into COR. James Lawson fixed an error (19/04/07) that prevented it reading in PCEnv (unsupported predefined operator diff in component intracellular_calcium_concentration. This variant of version 06 is parameterised for the BASIC model, excluding acetylcholine dependent modulation and electromechanical processes.</rdf:value>
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    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-02-06T14:05:00+13:00</dcterms:W3CDTF>
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    <rdf:value>This model has been curated by Penny Noble of Oxford University</rdf:value>
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    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2008-05-14T03:12:08+12:00</dcterms:W3CDTF>
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    <rdf:value>Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model. </rdf:value>
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    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">P</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Kohl</vCard:Family>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#3f08fae7-7464-48b3-90b1-870a1698a647">
    <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
    <rdf:value>penny.noble@dpag.ox.ac.uk</rdf:value>
  </rdf:Description>
</rdf:RDF>
</model>