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Model Mathematics

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Component: environment

Component: R

\frac{d}{d time} (R) = kom O + kim RI - (ko {Ca}^{2} R + ki Ca R)

Component: O

\frac{d}{d time} (O) = kim I + ko {Ca}^{2} R - (kom O + ki Ca O)

Component: I

\frac{d}{d time} (I) = ki Ca O + ko {Ca}^{2} RI - (kim I + kom I)

Component: RI

\frac{d}{d time} (RI) = ki Ca R + kom I - (kim RI + ko {Ca}^{2} RI)

Component: reaction_constants

Source: Derived from workspace Stern, Song, Sham, Yang, Boheler, Rios, 1999 at changeset 91ff987c1a4b.

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Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors