You are here: Home / Exposures / Tabak, Toporikova, Freeman, Bertram, 2007 / Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents (A-Type K Current)

Model Mathematics

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Component: environment

Component: membrane

\frac{d}{d time} (V) = \frac{- (I_Ca + I_K + I_SK + I_DA)}{C}

Component: I_K

I_K = gK n (V - VK)

Component: n

\frac{d}{d time} (n) = \frac{lambda (n_infinity - n)}{tau_n} n_infinity = \frac{1}{1 + ⅇ^{\frac{vn - V}{sn}}}

Component: I_Ca

I_Ca = gCa m_infinity (V - VCa)

Component: m

m_infinity = \frac{1}{1 + ⅇ^{\frac{vm - V}{sm}}}

Component: I_SK

I_SK = gSK s_infinity (V - VK) s_infinity = \frac{{Ca}^{2}}{{Ca}^{2} + {ks}^{2}}

Component: I_DA

I_DA = I_A I_A = gA a_infinity h (V - VK)

Component: a

a_infinity = \frac{1}{1 + ⅇ^{\frac{va - V}{sa}}}

Component: h

\frac{d}{d time} (h) = \frac{h_infinity - h}{tau_h} h_infinity = \frac{1}{1 + ⅇ^{\frac{V - vh}{sh}}}

Component: Ca

\frac{d}{d time} (Ca) = (- fc) (alpha I_Ca + kc Ca)

Component: PRL

PRL = kPRL {Ca}^{4}

Component: model_parameters

Source: Derived from workspace Tabak, Toporikova, Freeman, Bertram, 2007 at changeset c25affc42195.

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