Model Mathematics

\frac{d}{d time} (Y) = k1 - (k2 Y + k3 Y C)

\frac{d}{d time} (M) = kcdc25 preMPF + k3 Y C - (k2 M + kwee M)

\frac{d}{d time} (preMPF) = kwee M - (k2 preMPF + kcdc25 preMPF)

\frac{d}{d time} (Cdc25P) = \frac{k25 M Cdc25}{Km25 + Cdc25} - (\frac{k25r Cdc25P}{Km25r + Cdc25P}) k25ro = \frac{k25r}{p}

\frac{d}{d time} (Wee1) = \frac{(- kw) M Wee1}{Kmw + Wee1} + \frac{kwr Wee1P}{Kmwr + Wee1P} kwro = \frac{kwr}{p}

\frac{d}{d time} (IEP) = \frac{kie M IE}{Kmie + IE} - (\frac{kier IEP}{Kmier + IEP})

\frac{d}{d time} (APC_) = \frac{kap IEP APC}{Kmap + APC} - (\frac{kapr APC_}{Kmapr + APC_})

C = Cdc2tot - (M + preMPF)

Cdc25 = Cdc25tot - Cdc25P

Wee1P = Wee1tot - Wee1

IE = IEtot - IEP

APC = APCtot - APC_

p = s R + q

kcdc25 = V25 Cdc25 + V25_Cdc25P k2 = V2 APC + V2_APC_kwee = Vwee Wee1P + Vwee_Wee1