Generated Code
The following is matlab code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction()
% This is the "main function". In Matlab, things work best if you rename this function to match the filename.
[VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel();
end
function [algebraicVariableCount] = getAlgebraicVariableCount()
% Used later when setting a global variable with the number of algebraic variables.
% Note: This is not the "main method".
algebraicVariableCount =4;
end
% There are a total of 3 entries in each of the rate and state variable arrays.
% There are a total of 25 entries in the constant variable array.
%
function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel()
% Create ALGEBRAIC of correct size
global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount();
% Initialise constants and state variables
[INIT_STATES, CONSTANTS] = initConsts;
% Set timespan to solve over
tspan = [0, 10];
% Set numerical accuracy options for ODE solver
options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1);
% Solve model with ODE solver
[VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options);
% Compute algebraic variables
[RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS);
ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI);
% Plot state variables against variable of integration
[LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends();
figure();
plot(VOI, STATES);
xlabel(LEGEND_VOI);
l = legend(LEGEND_STATES);
set(l,'Interpreter','none');
end
function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends()
LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = '';
LEGEND_VOI = strpad('time in component environment (second)');
LEGEND_STATES(:,1) = strpad('Vm in component membrane (millivolt)');
LEGEND_CONSTANTS(:,1) = strpad('C in component membrane (picoF)');
LEGEND_ALGEBRAIC(:,3) = strpad('i_K in component potassium_current (picoA)');
LEGEND_ALGEBRAIC(:,4) = strpad('i_R in component repolarising_current (picoA)');
LEGEND_STATES(:,2) = strpad('IP3 in component IP3 (nanomolar)');
LEGEND_CONSTANTS(:,2) = strpad('m3IP3 in component IP3 (dimensionless)');
LEGEND_CONSTANTS(:,3) = strpad('m4IP3 in component IP3 (dimensionless)');
LEGEND_CONSTANTS(:,4) = strpad('kIP3 in component IP3 (first_order_rate_constant)');
LEGEND_CONSTANTS(:,5) = strpad('A in component IP3 (dimensionless)');
LEGEND_STATES(:,3) = strpad('Ca in component Ca (nanomolar)');
LEGEND_CONSTANTS(:,6) = strpad('m3SR in component Ca (dimensionless)');
LEGEND_CONSTANTS(:,7) = strpad('m4SR in component Ca (dimensionless)');
LEGEND_CONSTANTS(:,8) = strpad('m3PMCA in component Ca (dimensionless)');
LEGEND_CONSTANTS(:,9) = strpad('m4PMCA in component Ca (dimensionless)');
LEGEND_CONSTANTS(:,10) = strpad('kSR_rel in component Ca (flux)');
LEGEND_CONSTANTS(:,11) = strpad('kPMCA in component Ca (flux)');
LEGEND_ALGEBRAIC(:,2) = strpad('Jcat in component Jcat (flux)');
LEGEND_CONSTANTS(:,12) = strpad('ECa in component Jcat (millivolt)');
LEGEND_CONSTANTS(:,13) = strpad('Gcat in component Jcat (nanomolar_per_millivolt_second)');
LEGEND_CONSTANTS(:,14) = strpad('m3cat in component Jcat (dimensionless)');
LEGEND_CONSTANTS(:,15) = strpad('m4cat in component Jcat (dimensionless)');
LEGEND_CONSTANTS(:,16) = strpad('Gtot in component potassium_current (picoS)');
LEGEND_ALGEBRAIC(:,1) = strpad('PoBKCa in component potassium_current (dimensionless)');
LEGEND_CONSTANTS(:,17) = strpad('PoSKCa in component potassium_current (dimensionless)');
LEGEND_CONSTANTS(:,18) = strpad('E_K in component potassium_current (millivolt)');
LEGEND_CONSTANTS(:,19) = strpad('a in component potassium_current (dimensionless)');
LEGEND_CONSTANTS(:,20) = strpad('b in component potassium_current (dimensionless)');
LEGEND_CONSTANTS(:,21) = strpad('c in component potassium_current (dimensionless)');
LEGEND_CONSTANTS(:,22) = strpad('m3 in component potassium_current (dimensionless)');
LEGEND_CONSTANTS(:,23) = strpad('m4 in component potassium_current (dimensionless)');
LEGEND_CONSTANTS(:,24) = strpad('GR in component repolarising_current (picoS)');
LEGEND_CONSTANTS(:,25) = strpad('Vrest in component repolarising_current (millivolt)');
LEGEND_RATES(:,1) = strpad('d/dt Vm in component membrane (millivolt)');
LEGEND_RATES(:,2) = strpad('d/dt IP3 in component IP3 (nanomolar)');
LEGEND_RATES(:,3) = strpad('d/dt Ca in component Ca (nanomolar)');
LEGEND_STATES = LEGEND_STATES';
LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC';
LEGEND_RATES = LEGEND_RATES';
LEGEND_CONSTANTS = LEGEND_CONSTANTS';
end
function [STATES, CONSTANTS] = initConsts()
VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = [];
STATES(:,1) = -31.1;
CONSTANTS(:,1) = 1.0;
STATES(:,2) = 1.0;
CONSTANTS(:,2) = 4.0;
CONSTANTS(:,3) = 55.0;
CONSTANTS(:,4) = 0.1733;
CONSTANTS(:,5) = 0.211;
STATES(:,3) = 50.0;
CONSTANTS(:,6) = 1.1;
CONSTANTS(:,7) = 0.3;
CONSTANTS(:,8) = -6.19;
CONSTANTS(:,9) = 0.39;
CONSTANTS(:,10) = 180.0;
CONSTANTS(:,11) = 0.679;
CONSTANTS(:,12) = 50.0;
CONSTANTS(:,13) = 0.66;
CONSTANTS(:,14) = -6.18;
CONSTANTS(:,15) = 0.37;
CONSTANTS(:,16) = 6927;
CONSTANTS(:,17) = 0.5;
CONSTANTS(:,18) = -80.0;
CONSTANTS(:,19) = 53.3;
CONSTANTS(:,20) = -80.8;
CONSTANTS(:,21) = -6.4;
CONSTANTS(:,22) = 1.32E-3;
CONSTANTS(:,23) = 0.30;
CONSTANTS(:,24) = 955.0;
CONSTANTS(:,25) = -31.1;
if (isempty(STATES)), warning('Initial values for states not set');, end
end
function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS)
global algebraicVariableCount;
statesSize = size(STATES);
statesColumnCount = statesSize(2);
if ( statesColumnCount == 1)
STATES = STATES';
ALGEBRAIC = zeros(1, algebraicVariableCount);
utilOnes = 1;
else
statesRowCount = statesSize(1);
ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount);
RATES = zeros(statesRowCount, statesColumnCount);
utilOnes = ones(statesRowCount, 1);
end
RATES(:,2) = CONSTANTS(:,5).*(1.00000+ tanh((CONSTANTS(:,2) - VOI)./CONSTANTS(:,3))) - CONSTANTS(:,4).*STATES(:,2);
RATES(:,3) = (CONSTANTS(:,10)./2.00000).*(1.00000+ tanh((STATES(:,2) - CONSTANTS(:,6))./CONSTANTS(:,7))) - (CONSTANTS(:,11)./2.00000).*(1.00000+ tanh((arbitrary_log(STATES(:,3), 10) - CONSTANTS(:,8))./CONSTANTS(:,9)));
ALGEBRAIC(:,1) = 0.500000.*(1.00000+ tanh(( (arbitrary_log(STATES(:,3), 10) - CONSTANTS(:,21)).*(STATES(:,1) - CONSTANTS(:,20)) - CONSTANTS(:,19))./( CONSTANTS(:,22).*power((STATES(:,1)+ CONSTANTS(:,19).*(arbitrary_log(STATES(:,3), 10) - CONSTANTS(:,21))) - CONSTANTS(:,20), 2.00000)+CONSTANTS(:,23))));
ALGEBRAIC(:,3) = CONSTANTS(:,16).*(STATES(:,1) - CONSTANTS(:,18)).*( 0.400000.*ALGEBRAIC(:,1)+ 0.600000.*CONSTANTS(:,17));
ALGEBRAIC(:,4) = CONSTANTS(:,24).*(STATES(:,1) - CONSTANTS(:,25));
RATES(:,1) = - (1.00000./CONSTANTS(:,1)).*(ALGEBRAIC(:,3)+ALGEBRAIC(:,4));
RATES = RATES';
end
% Calculate algebraic variables
function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI)
statesSize = size(STATES);
statesColumnCount = statesSize(2);
if ( statesColumnCount == 1)
STATES = STATES';
utilOnes = 1;
else
statesRowCount = statesSize(1);
utilOnes = ones(statesRowCount, 1);
end
ALGEBRAIC(:,1) = 0.500000.*(1.00000+ tanh(( (arbitrary_log(STATES(:,3), 10) - CONSTANTS(:,21)).*(STATES(:,1) - CONSTANTS(:,20)) - CONSTANTS(:,19))./( CONSTANTS(:,22).*power((STATES(:,1)+ CONSTANTS(:,19).*(arbitrary_log(STATES(:,3), 10) - CONSTANTS(:,21))) - CONSTANTS(:,20), 2.00000)+CONSTANTS(:,23))));
ALGEBRAIC(:,3) = CONSTANTS(:,16).*(STATES(:,1) - CONSTANTS(:,18)).*( 0.400000.*ALGEBRAIC(:,1)+ 0.600000.*CONSTANTS(:,17));
ALGEBRAIC(:,4) = CONSTANTS(:,24).*(STATES(:,1) - CONSTANTS(:,25));
ALGEBRAIC(:,2) = ( CONSTANTS(:,13).*(CONSTANTS(:,12) - STATES(:,1))).*( 0.500000.*(1.00000+ tanh((arbitrary_log(STATES(:,3), 10) - CONSTANTS(:,14))./CONSTANTS(:,15))));
end
% Compute a logarithm to any base" +
function x = arbitrary_log(a, base)
x = log(a) ./ log(base);
end
% Pad out or shorten strings to a set length
function strout = strpad(strin)
req_length = 160;
insize = size(strin,2);
if insize > req_length
strout = strin(1:req_length);
else
strout = [strin, blanks(req_length - insize)];
end
end