You are here: Home / Exposures / Schuster, Beny, Meister, 2003 / Modelling the electrophysiological endothelial cell response to bradykinin

Model Mathematics

Component based math viewer is available

Component: environment

Component: membrane

\frac{d}{d time} (Vm) = (- (\frac{1.0}{C})) (i_K + i_R)

Component: IP3

\frac{d}{d time} (IP3) = A (1.0 + \tanh (\frac{m3IP3 - time}{m4IP3})) - (kIP3 IP3)

Component: Ca

\frac{d}{d time} (Ca) = \frac{kSR_rel}{2.0} (1.0 + \tanh (\frac{IP3 - m3SR}{m4SR})) - (\frac{kPMCA}{2.0} (1.0 + \tanh (\frac{\log_{10} Ca - m3PMCA}{m4PMCA})))

Component: Jcat

Jcat = Gcat (ECa - Vm) 0.5 (1.0 + \tanh (\frac{\log_{10} Ca - m3cat}{m4cat}))

Component: potassium_current

i_K = Gtot (Vm - E_K) (0.4 PoBKCa + 0.6 PoSKCa) PoBKCa = 0.5 (1.0 + \tanh (\frac{(\log_{10} Ca - c) (Vm - b) - a}{m3 {(Vm + a (\log_{10} Ca - c) - b)}^{2.0} + m4}))

Component: repolarising_current

i_R = GR (Vm - Vrest)

Source: Derived from workspace Schuster, Beny, Meister, 2003 at changeset 143e3fe33508.

Collaboration: To begin collaborating on this work, please use your git client and issue this command:

Downloads

Views Available

Tools

License: This work is licensed under a Creative Commons Attribution 3.0 Unported License.

Modelling the electrophysiological endothelial cell response to bradykinin