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Model Mathematics

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Component: environment

Component: parameters

Component: D

\frac{d}{d time} (D) = \frac{a_D k GF}{1 + k GF} - (d_D E D)

Component: E

\frac{d}{d time} (E) = a_E (1 + a_f (theta - R_S)) 1 - (d_E X E)

Component: R

\frac{d}{d time} (R) = \frac{p_X X (R_T - R_S - R)}{q_X + (R_T - R_S - R) + X} - (p_S (theta - R_S) R)

Component: R_S

\frac{d}{d time} (R_S) = p_S (theta - R_S) R - (\frac{p_D R_S D}{q_D + R_S + D}) - (\frac{p_E R_S E}{q_E + R_S + E})

Component: X

\frac{d}{d time} (X) = a_X E + f (theta - R_S) + g X^{2} E - (d_X X)

Component: unpho_RB

unpho_RB = R + R_S

Component: free_E2F

free_E2F = theta - R_S

Source: Derived from workspace Obeyesekere, Zimmerman, Tecarro, Auchmuty, 1999 at changeset c1d21d0ec76a.

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A model of cell cycle behavior dominated by kinetics of a pathway stimulated by growth factors