Generated Code
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/*
There are a total of 21 entries in the algebraic variable array.
There are a total of 11 entries in each of the rate and state variable arrays.
There are a total of 33 entries in the constant variable array.
*/
/*
* VOI is time in component environment (minute).
* CONSTANTS[0] is k1 in component rate_constants (first_order_rate_constant).
* CONSTANTS[1] is k1_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[2] is k1__ in component rate_constants (first_order_rate_constant).
* CONSTANTS[3] is kn1 in component rate_constants (first_order_rate_constant).
* CONSTANTS[4] is k2 in component rate_constants (first_order_rate_constant).
* CONSTANTS[5] is kn2 in component rate_constants (first_order_rate_constant).
* CONSTANTS[6] is k3 in component rate_constants (first_order_rate_constant).
* CONSTANTS[7] is k3_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[8] is kn4 in component rate_constants (first_order_rate_constant).
* CONSTANTS[9] is k5 in component rate_constants (first_order_rate_constant).
* CONSTANTS[10] is kn6 in component rate_constants (first_order_rate_constant).
* CONSTANTS[11] is k8 in component rate_constants (first_order_rate_constant).
* CONSTANTS[12] is k9 in component rate_constants (first_order_rate_constant).
* CONSTANTS[13] is k10 in component rate_constants (first_order_rate_constant).
* CONSTANTS[14] is k17 in component rate_constants (first_order_rate_constant).
* CONSTANTS[15] is k18 in component rate_constants (first_order_rate_constant).
* CONSTANTS[16] is k19 in component rate_constants (first_order_rate_constant).
* CONSTANTS[17] is k20 in component rate_constants (first_order_rate_constant).
* CONSTANTS[18] is k21 in component rate_constants (first_order_rate_constant).
* CONSTANTS[19] is k22 in component rate_constants (first_order_rate_constant).
* CONSTANTS[20] is k24 in component rate_constants (first_order_rate_constant).
* CONSTANTS[21] is k25 in component rate_constants (first_order_rate_constant).
* CONSTANTS[22] is k25_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[23] is k26 in component rate_constants (first_order_rate_constant).
* CONSTANTS[24] is k26_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[25] is k28 in component rate_constants (first_order_rate_constant).
* CONSTANTS[26] is k29 in component rate_constants (first_order_rate_constant).
* STATES[0] is a_CyclinE_Cdk2 in component a_CyclinE_Cdk2 (dimensionless).
* ALGEBRAIC[0] is V_2 in component V_2 (first_order_rate_constant).
* ALGEBRAIC[13] is V_10 in component V_10 (first_order_rate_constant).
* ALGEBRAIC[2] is V_n2 in component V_n2 (first_order_rate_constant).
* ALGEBRAIC[12] is V_9 in component V_9 (first_order_rate_constant).
* ALGEBRAIC[14] is V_21 in component V_21 (first_order_rate_constant).
* STATES[1] is i_CyclinE_Cdk2 in component i_CyclinE_Cdk2 (dimensionless).
* ALGEBRAIC[5] is V_3 in component V_3 (first_order_rate_constant).
* ALGEBRAIC[9] is V_5 in component V_5 (first_order_rate_constant).
* STATES[2] is pRB_E2F in component pRB_E2F (dimensionless).
* CONSTANTS[32] is V_n1 in component V_n1 (first_order_rate_constant).
* ALGEBRAIC[1] is V_1 in component V_1 (first_order_rate_constant).
* STATES[3] is E2F in component E2F (dimensionless).
* CONSTANTS[27] is V_4 in component E2F (first_order_rate_constant).
* ALGEBRAIC[6] is V_18 in component V_18 (first_order_rate_constant).
* ALGEBRAIC[3] is V_n4 in component V_n4 (first_order_rate_constant).
* STATES[4] is pRB in component pRB (dimensionless).
* CONSTANTS[28] is V_27 in component pRB (first_order_rate_constant).
* ALGEBRAIC[4] is V_26 in component V_26 (first_order_rate_constant).
* ALGEBRAIC[10] is V_29 in component V_29 (first_order_rate_constant).
* ALGEBRAIC[7] is V_28 in component V_28 (first_order_rate_constant).
* STATES[5] is CycD_Cdk4 in component CycD_Cdk4 (dimensionless).
* CONSTANTS[29] is V_6 in component CycD_Cdk4 (first_order_rate_constant).
* ALGEBRAIC[18] is V_20 in component V_20 (first_order_rate_constant).
* ALGEBRAIC[8] is V_n6 in component V_n6 (first_order_rate_constant).
* ALGEBRAIC[16] is V_19 in component V_19 (first_order_rate_constant).
* ALGEBRAIC[15] is V_17 in component V_17 (first_order_rate_constant).
* STATES[6] is p27 in component p27 (dimensionless).
* CONSTANTS[30] is V_7 in component p27 (first_order_rate_constant).
* ALGEBRAIC[11] is V_8 in component V_8 (first_order_rate_constant).
* ALGEBRAIC[20] is V_22 in component V_22 (first_order_rate_constant).
* STATES[7] is CycE_Cdk2_p27 in component CycE_Cdk2_p27 (dimensionless).
* STATES[8] is CycD_Cdk4_p27 in component CycD_Cdk4_p27 (dimensionless).
* STATES[9] is p16 in component p16 (dimensionless).
* CONSTANTS[31] is V_23 in component p16 (first_order_rate_constant).
* ALGEBRAIC[19] is V_25 in component V_25 (first_order_rate_constant).
* ALGEBRAIC[17] is V_24 in component V_24 (first_order_rate_constant).
* STATES[10] is pRB_P in component pRB_P (dimensionless).
* RATES[0] is d/dt a_CyclinE_Cdk2 in component a_CyclinE_Cdk2 (dimensionless).
* RATES[1] is d/dt i_CyclinE_Cdk2 in component i_CyclinE_Cdk2 (dimensionless).
* RATES[2] is d/dt pRB_E2F in component pRB_E2F (dimensionless).
* RATES[3] is d/dt E2F in component E2F (dimensionless).
* RATES[4] is d/dt pRB in component pRB (dimensionless).
* RATES[5] is d/dt CycD_Cdk4 in component CycD_Cdk4 (dimensionless).
* RATES[6] is d/dt p27 in component p27 (dimensionless).
* RATES[7] is d/dt CycE_Cdk2_p27 in component CycE_Cdk2_p27 (dimensionless).
* RATES[8] is d/dt CycD_Cdk4_p27 in component CycD_Cdk4_p27 (dimensionless).
* RATES[9] is d/dt p16 in component p16 (dimensionless).
* RATES[10] is d/dt pRB_P in component pRB_P (dimensionless).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
CONSTANTS[0] = 0.1;
CONSTANTS[1] = 0.5;
CONSTANTS[2] = 0.5;
CONSTANTS[3] = 0.001;
CONSTANTS[4] = 0.1;
CONSTANTS[5] = 1;
CONSTANTS[6] = 1.42;
CONSTANTS[7] = 0;
CONSTANTS[8] = 0.016;
CONSTANTS[9] = 0.02;
CONSTANTS[10] = 5;
CONSTANTS[11] = 2;
CONSTANTS[12] = 2;
CONSTANTS[13] = 0.035;
CONSTANTS[14] = 3.5;
CONSTANTS[15] = 0.0001;
CONSTANTS[16] = 0.05;
CONSTANTS[17] = 0.01;
CONSTANTS[18] = 0.1;
CONSTANTS[19] = 0.001;
CONSTANTS[20] = 0.1;
CONSTANTS[21] = 0.01;
CONSTANTS[22] = 0.02;
CONSTANTS[23] = 0.01;
CONSTANTS[24] = 0.1;
CONSTANTS[25] = 0.01;
CONSTANTS[26] = 0.001;
STATES[0] = 0;
STATES[1] = 0.01;
STATES[2] = 1.95;
STATES[3] = 0;
CONSTANTS[27] = 0.000001;
STATES[4] = 0.05;
CONSTANTS[28] = 0.01;
STATES[5] = 0;
CONSTANTS[29] = 0.018;
STATES[6] = 5;
CONSTANTS[30] = 0.0001;
STATES[7] = 1;
STATES[8] = 0;
STATES[9] = 5;
CONSTANTS[31] = 0.2;
STATES[10] = 0.01;
CONSTANTS[32] = CONSTANTS[3];
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[1] = CONSTANTS[1]*STATES[5]*STATES[2]+ CONSTANTS[2]*STATES[8]*STATES[2]+ CONSTANTS[0]*STATES[0]*STATES[2];
RATES[2] = CONSTANTS[32] - ALGEBRAIC[1];
ALGEBRAIC[6] = CONSTANTS[15]*STATES[3];
ALGEBRAIC[3] = CONSTANTS[8]*STATES[3];
RATES[3] = (ALGEBRAIC[1]+CONSTANTS[27]+ALGEBRAIC[6]) - (CONSTANTS[32]+ALGEBRAIC[3]);
ALGEBRAIC[0] = CONSTANTS[4]*STATES[0]*STATES[1];
ALGEBRAIC[2] = CONSTANTS[5]*STATES[0];
ALGEBRAIC[5] = CONSTANTS[6]*STATES[3]+CONSTANTS[7];
ALGEBRAIC[9] = CONSTANTS[9]*STATES[1];
RATES[1] = (ALGEBRAIC[5]+ALGEBRAIC[2]) - (ALGEBRAIC[0]+ALGEBRAIC[9]);
ALGEBRAIC[4] = CONSTANTS[23]/( (1.00000+ CONSTANTS[24]*STATES[9])*1.00000);
ALGEBRAIC[10] = CONSTANTS[26]*STATES[10];
ALGEBRAIC[7] = CONSTANTS[25]*STATES[4];
RATES[4] = (CONSTANTS[28]+ALGEBRAIC[4]+ALGEBRAIC[10]) - (CONSTANTS[32]+ALGEBRAIC[7]);
RATES[10] = ALGEBRAIC[1] - ALGEBRAIC[10];
ALGEBRAIC[13] = CONSTANTS[13]*STATES[7];
ALGEBRAIC[12] = CONSTANTS[12]*STATES[6]*STATES[0];
RATES[7] = ALGEBRAIC[12] - ALGEBRAIC[13];
ALGEBRAIC[14] = CONSTANTS[18]*pow(STATES[0], 2.00000);
RATES[0] = (ALGEBRAIC[0]+ALGEBRAIC[13]) - (ALGEBRAIC[2]+ALGEBRAIC[12]+ALGEBRAIC[14]);
ALGEBRAIC[18] = CONSTANTS[17]*STATES[8];
ALGEBRAIC[8] = CONSTANTS[10]*STATES[5];
ALGEBRAIC[16] = CONSTANTS[16]*STATES[6]*STATES[5];
ALGEBRAIC[15] = CONSTANTS[14]*STATES[9]*STATES[5];
RATES[5] = (CONSTANTS[29]+ALGEBRAIC[18]) - (ALGEBRAIC[8]+ALGEBRAIC[16]+ALGEBRAIC[15]);
RATES[8] = ALGEBRAIC[16] - ALGEBRAIC[18];
ALGEBRAIC[19] = CONSTANTS[21]/( (1.00000+ CONSTANTS[22]*STATES[4])*1.00000);
ALGEBRAIC[17] = CONSTANTS[20]*STATES[9];
RATES[9] = (CONSTANTS[31]+ALGEBRAIC[19]) - (ALGEBRAIC[15]+ALGEBRAIC[17]);
ALGEBRAIC[11] = CONSTANTS[11]*STATES[6]*STATES[0];
ALGEBRAIC[20] = CONSTANTS[19]*STATES[6];
RATES[6] = (CONSTANTS[30]+ALGEBRAIC[13]+ALGEBRAIC[18]) - (ALGEBRAIC[11]+ALGEBRAIC[12]+ALGEBRAIC[16]+ALGEBRAIC[20]);
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[1] = CONSTANTS[1]*STATES[5]*STATES[2]+ CONSTANTS[2]*STATES[8]*STATES[2]+ CONSTANTS[0]*STATES[0]*STATES[2];
ALGEBRAIC[6] = CONSTANTS[15]*STATES[3];
ALGEBRAIC[3] = CONSTANTS[8]*STATES[3];
ALGEBRAIC[0] = CONSTANTS[4]*STATES[0]*STATES[1];
ALGEBRAIC[2] = CONSTANTS[5]*STATES[0];
ALGEBRAIC[5] = CONSTANTS[6]*STATES[3]+CONSTANTS[7];
ALGEBRAIC[9] = CONSTANTS[9]*STATES[1];
ALGEBRAIC[4] = CONSTANTS[23]/( (1.00000+ CONSTANTS[24]*STATES[9])*1.00000);
ALGEBRAIC[10] = CONSTANTS[26]*STATES[10];
ALGEBRAIC[7] = CONSTANTS[25]*STATES[4];
ALGEBRAIC[13] = CONSTANTS[13]*STATES[7];
ALGEBRAIC[12] = CONSTANTS[12]*STATES[6]*STATES[0];
ALGEBRAIC[14] = CONSTANTS[18]*pow(STATES[0], 2.00000);
ALGEBRAIC[18] = CONSTANTS[17]*STATES[8];
ALGEBRAIC[8] = CONSTANTS[10]*STATES[5];
ALGEBRAIC[16] = CONSTANTS[16]*STATES[6]*STATES[5];
ALGEBRAIC[15] = CONSTANTS[14]*STATES[9]*STATES[5];
ALGEBRAIC[19] = CONSTANTS[21]/( (1.00000+ CONSTANTS[22]*STATES[4])*1.00000);
ALGEBRAIC[17] = CONSTANTS[20]*STATES[9];
ALGEBRAIC[11] = CONSTANTS[11]*STATES[6]*STATES[0];
ALGEBRAIC[20] = CONSTANTS[19]*STATES[6];
}