Model Mathematics

Component: environment

Component: rate_constants

Component: a_CyclinE_Cdk2

ddtimea_CyclinE_Cdk2=V_2+V_10-V_n2+V_9+V_21

Component: i_CyclinE_Cdk2

ddtimei_CyclinE_Cdk2=V_3+V_n2-V_2+V_5

Component: pRB_E2F

ddtimepRB_E2F=V_n1-V_1

Component: E2F

ddtimeE2F=V_1+V_4+V_18-V_n1+V_n4

Component: pRB

ddtimepRB=V_27+V_26+V_29-V_n1+V_28

Component: CycD_Cdk4

ddtimeCycD_Cdk4=V_6+V_20-V_n6+V_19+V_17

Component: p27

ddtimep27=V_7+V_10+V_20-V_8+V_9+V_19+V_22

Component: CycE_Cdk2_p27

ddtimeCycE_Cdk2_p27=V_9-V_10

Component: CycD_Cdk4_p27

ddtimeCycD_Cdk4_p27=V_19-V_20

Component: p16

ddtimep16=V_23+V_25-V_17+V_24

Component: pRB_P

ddtimepRB_P=V_1-V_29

Component: V_1

V_1=k1_⁢CycD_Cdk4⁢pRB_E2F+k1__⁢CycD_Cdk4_p27⁢pRB_E2F+k1⁢a_CyclinE_Cdk2⁢pRB_E2F

Component: V_n1

V_n1=kn1

Component: V_2

V_2=k2⁢a_CyclinE_Cdk2⁢i_CyclinE_Cdk2

Component: V_n2

V_n2=kn2⁢a_CyclinE_Cdk2

Component: V_3

V_3=k3⁢E2F+k3_

Component: V_n4

V_n4=kn4⁢E2F

Component: V_5

V_5=k5⁢i_CyclinE_Cdk2

Component: V_n6

V_n6=kn6⁢CycD_Cdk4

Component: V_8

V_8=k8⁢p27⁢a_CyclinE_Cdk2

Component: V_9

V_9=k9⁢p27⁢a_CyclinE_Cdk2

Component: V_10

V_10=k10⁢CycE_Cdk2_p27

Component: V_17

V_17=k17⁢p16⁢CycD_Cdk4

Component: V_18

V_18=k18⁢E2F

Component: V_19

V_19=k19⁢p27⁢CycD_Cdk4

Component: V_20

V_20=k20⁢CycD_Cdk4_p27

Component: V_21

V_21=k21⁢a_CyclinE_Cdk22

Component: V_22

V_22=k22⁢p27

Component: V_24

V_24=k24⁢p16

Component: V_25

V_25=k251+k25_⁢pRB⁢1

Component: V_26

V_26=k261+k26_⁢p16⁢1

Component: V_28

V_28=k28⁢pRB

Component: V_29

V_29=k29⁢pRB_P