- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-28 17:42:22+12:00
- Desc:
- Set interpolate solution to be False, which gives more accurate results for I_Na at around -65mV (i.e., eliminate the notch in Fig6)
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/692/rawfile/2a5e59efe1005435ff0fabf7eb400f2929bbb8f8/Doc/Periodic_stimulation_SA.rst
Sensitivity analysis
--------------------------
In the `Sensitivity analysis experiment <../Experiments/Periodic_stimulation_SA.cellml>`_, the `Membrane potential component <../Components/Membrane_potential.cellml/view>`_ is configured and parameterised with an applied `periodic stimulus current <../Experiments/Periodic_IStim_protocol.cellml>`_.
You can change the parameters of stimulation in the component ``Istim_parameters`` and the maximum conductances of ionic channels in the component ``g_parameters``.
You can also bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../Simulation/Periodic_stimulation_SA.sedml>`__ into OpenCOR and executing the simulation.
Sensitivity analysis result
----------------------------
Figure [#]_ shows sensitivity analysis by 50% increase or decrease in maximum channel conductance. This evaluates the contributions of key ionic currents towards hJSMC membrane voltage. (e) shows the free intracellular :math:`Ca^{2+}` concentrations corresponding to changes in (d).
.. [#]
.. figure:: ../Simulation/simFig13.png
:width: 85%
:align: center
:alt: simFig13
