Generated Code
The following is f77 code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
C
C There are a total of 35 entries in the algebraic variable array.
C There are a total of 18 entries in each of the rate and state variable arrays.
C There are a total of 37 entries in the constant variable array.
C
C
C CONSTS(1) is kappa_R_12 in component BG_parameters (fmol_per_sec).
C CONSTS(2) is kappa_R_34 in component BG_parameters (fmol_per_sec).
C CONSTS(3) is kappa_R_56 in component BG_parameters (fmol_per_sec).
C CONSTS(4) is kappa_R_78 in component BG_parameters (fmol_per_sec).
C CONSTS(5) is kappa_R_1a_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(6) is kappa_R_1b_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(7) is kappa_R_2a_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(8) is kappa_R_2b_cGMP in component BG_parameters (fmol_per_sec).
C CONSTS(9) is kappa_R_1_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(10) is kappa_R_2_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(11) is kappa_R_3_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(12) is kappa_R_4_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(13) is kappa_R_DNO_sGC in component BG_parameters (fmol_per_sec).
C CONSTS(14) is K_A in component BG_parameters (per_fmol).
C CONSTS(15) is K_M in component BG_parameters (per_fmol).
C CONSTS(16) is K_Mp in component BG_parameters (per_fmol).
C CONSTS(17) is K_AM in component BG_parameters (per_fmol).
C CONSTS(18) is K_AMp in component BG_parameters (per_fmol).
C CONSTS(19) is K_Pi in component BG_parameters (per_fmol).
C CONSTS(20) is K_Ca_i in component BG_parameters (per_fmol).
C CONSTS(21) is K_cGMP in component BG_parameters (per_fmol).
C CONSTS(22) is K_GTP in component BG_parameters (per_fmol).
C CONSTS(23) is K_E5c in component BG_parameters (per_fmol).
C CONSTS(24) is K_PDE in component BG_parameters (per_fmol).
C CONSTS(25) is K_GTP_E5c in component BG_parameters (per_fmol).
C CONSTS(26) is K_cGMP_PDE in component BG_parameters (per_fmol).
C CONSTS(27) is K_GMP in component BG_parameters (per_fmol).
C CONSTS(28) is K_Eb in component BG_parameters (per_fmol).
C CONSTS(29) is K_NO in component BG_parameters (per_fmol).
C CONSTS(30) is K_E6c in component BG_parameters (per_fmol).
C CONSTS(31) is K_NO_product in component BG_parameters (per_fmol).
C VOI is t in component environment (second).
C CONSTS(32) is vol_myo in component environment (pL).
C STATES(1) is q_A in component environment (fmol).
C STATES(2) is q_M in component environment (fmol).
C STATES(3) is q_Mp in component environment (fmol).
C STATES(4) is q_AM in component environment (fmol).
C STATES(5) is q_AMp in component environment (fmol).
C STATES(6) is q_Pi in component environment (fmol).
C STATES(7) is q_Ca_i in component environment (fmol).
C STATES(8) is q_cGMP in component environment (fmol).
C STATES(9) is q_GTP in component environment (fmol).
C STATES(10) is q_E5c in component environment (fmol).
C STATES(11) is q_PDE in component environment (fmol).
C STATES(12) is q_GTP_E5c in component environment (fmol).
C STATES(13) is q_cGMP_PDE in component environment (fmol).
C STATES(14) is q_GMP in component environment (fmol).
C STATES(15) is q_Eb in component environment (fmol).
C STATES(16) is q_NO in component environment (fmol).
C STATES(17) is q_E6c in component environment (fmol).
C STATES(18) is q_NO_product in component environment (fmol).
C ALGBRC(10) is v_R_12 in component HaiMurphy (fmol_per_sec).
C ALGBRC(11) is v_R_34 in component HaiMurphy (fmol_per_sec).
C ALGBRC(12) is v_R_56 in component HaiMurphy (fmol_per_sec).
C ALGBRC(13) is v_R_78 in component HaiMurphy (fmol_per_sec).
C CONSTS(33) is n_Cai_SM in component environment (dimensionless).
C ALGBRC(21) is v_R_1a_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(22) is v_R_1b_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(23) is v_R_2a_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(24) is v_R_2b_cGMP in component cGMP (fmol_per_sec).
C ALGBRC(31) is v_R_1_sGC in component sGC (fmol_per_sec).
C ALGBRC(32) is v_R_2_sGC in component sGC (fmol_per_sec).
C ALGBRC(33) is v_R_3_sGC in component sGC (fmol_per_sec).
C ALGBRC(34) is v_R_4_sGC in component sGC (fmol_per_sec).
C ALGBRC(35) is v_R_DNO_sGC in component sGC (fmol_per_sec).
C CONSTS(34) is v_NO_generation in component environment (fmol_per_sec).
C ALGBRC(2) is stress in component environment (dimensionless).
C CONSTS(35) is R in component constants (J_per_K_per_mol).
C CONSTS(36) is T in component constants (kelvin).
C CONSTS(37) is F in component constants (C_per_mol).
C ALGBRC(1) is mu_A in component HaiMurphy (J_per_mol).
C ALGBRC(3) is mu_M in component HaiMurphy (J_per_mol).
C ALGBRC(4) is mu_Mp in component HaiMurphy (J_per_mol).
C ALGBRC(5) is mu_AM in component HaiMurphy (J_per_mol).
C ALGBRC(6) is mu_AMp in component HaiMurphy (J_per_mol).
C ALGBRC(7) is mu_Pi in component HaiMurphy (J_per_mol).
C ALGBRC(8) is mu_Ca_i in component HaiMurphy (J_per_mol).
C ALGBRC(9) is mu_cGMP in component HaiMurphy (J_per_mol).
C ALGBRC(14) is mu_GTP in component cGMP (J_per_mol).
C ALGBRC(15) is mu_E5c in component cGMP (J_per_mol).
C ALGBRC(16) is mu_cGMP in component cGMP (J_per_mol).
C ALGBRC(17) is mu_PDE in component cGMP (J_per_mol).
C ALGBRC(18) is mu_GTP_E5c in component cGMP (J_per_mol).
C ALGBRC(19) is mu_cGMP_PDE in component cGMP (J_per_mol).
C ALGBRC(20) is mu_GMP in component cGMP (J_per_mol).
C ALGBRC(25) is mu_Eb in component sGC (J_per_mol).
C ALGBRC(26) is mu_NO in component sGC (J_per_mol).
C ALGBRC(27) is mu_E6c in component sGC (J_per_mol).
C ALGBRC(28) is mu_E5c in component sGC (J_per_mol).
C ALGBRC(29) is mu_cGMP in component sGC (J_per_mol).
C ALGBRC(30) is mu_NO_product in component sGC (J_per_mol).
C RATES(1) is d/dt q_A in component environment (fmol).
C RATES(2) is d/dt q_M in component environment (fmol).
C RATES(3) is d/dt q_Mp in component environment (fmol).
C RATES(4) is d/dt q_AM in component environment (fmol).
C RATES(5) is d/dt q_AMp in component environment (fmol).
C RATES(6) is d/dt q_Pi in component environment (fmol).
C RATES(7) is d/dt q_Ca_i in component environment (fmol).
C RATES(8) is d/dt q_cGMP in component environment (fmol).
C RATES(9) is d/dt q_GTP in component environment (fmol).
C RATES(10) is d/dt q_E5c in component environment (fmol).
C RATES(11) is d/dt q_PDE in component environment (fmol).
C RATES(12) is d/dt q_GTP_E5c in component environment (fmol).
C RATES(13) is d/dt q_cGMP_PDE in component environment (fmol).
C RATES(14) is d/dt q_GMP in component environment (fmol).
C RATES(15) is d/dt q_Eb in component environment (fmol).
C RATES(16) is d/dt q_NO in component environment (fmol).
C RATES(17) is d/dt q_E6c in component environment (fmol).
C RATES(18) is d/dt q_NO_product in component environment (fmol).
C
SUBROUTINE initConsts(CONSTS, RATES, STATES)
REAL CONSTS(*), RATES(*), STATES(*)
CONSTS(1) = 0.0628586
CONSTS(2) = 10.3507
CONSTS(3) = 1.13145
CONSTS(4) = 0.031236
CONSTS(5) = 192.663
CONSTS(6) = 0.00328297
CONSTS(7) = 56591.2
CONSTS(8) = 0.0110353
CONSTS(9) = 3.61127e+06
CONSTS(10) = 0.00328297
CONSTS(11) = 4.92446
CONSTS(12) = 0.0361127
CONSTS(13) = 0.01
CONSTS(14) = 1.65213
CONSTS(15) = 15.6959
CONSTS(16) = 0.105259
CONSTS(17) = 1.44065
CONSTS(18) = 0.00966114
CONSTS(19) = 723.915
CONSTS(20) = 1
CONSTS(21) = 1
CONSTS(22) = 17040
CONSTS(23) = 0.304602
CONSTS(24) = 17.6706
CONSTS(25) = 5190.42
CONSTS(26) = 35.3412
CONSTS(27) = 0.0051282
CONSTS(28) = 0.0276911
CONSTS(29) = 1
CONSTS(30) = 30.4602
CONSTS(31) = 0.1
CONSTS(32) = 1
STATES(1) = 1e-6
STATES(2) = 1e-6
STATES(3) = 0
STATES(4) = 0
STATES(5) = 0
STATES(6) = 15
STATES(7) = 1e-3
STATES(8) = 1e-6
STATES(9) = 0.0005
STATES(10) = 1e-16
STATES(11) = 1e-10
STATES(12) = 1e-16
STATES(13) = 1e-16
STATES(14) = 1e-16
STATES(15) = 1e-6
STATES(16) = 0.00836
STATES(17) = 1e-16
STATES(18) = 1e-16
CONSTS(33) = 1.66
CONSTS(34) = 0.000114
CONSTS(35) = 8.31
CONSTS(36) = 310
CONSTS(37) = 96485
RETURN
END
SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC)
REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
ALGBRC(3) = CONSTS(35)*CONSTS(36)*log( CONSTS(15)*STATES(2))
ALGBRC(4) = CONSTS(35)*CONSTS(36)*log( CONSTS(16)*STATES(3))
ALGBRC(7) = CONSTS(35)*CONSTS(36)*log( CONSTS(19)*STATES(6))
ALGBRC(8) = CONSTS(35)*CONSTS(36)*log( CONSTS(20)*STATES(7))
ALGBRC(9) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8))
ALGBRC(10) = CONSTS(1)*(EXP((ALGBRC(3)+ALGBRC(7)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(4)+ALGBRC(9))/( CONSTS(35)*CONSTS(36))))
ALGBRC(1) = CONSTS(35)*CONSTS(36)*log( CONSTS(14)*STATES(1))
ALGBRC(6) = CONSTS(35)*CONSTS(36)*log( CONSTS(18)*STATES(5))
ALGBRC(11) = CONSTS(2)*(EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(6)/( CONSTS(35)*CONSTS(36))))
RATES(3) = ALGBRC(10) - ALGBRC(11)
ALGBRC(5) = CONSTS(35)*CONSTS(36)*log( CONSTS(17)*STATES(4))
ALGBRC(12) = CONSTS(3)*(EXP((ALGBRC(6)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(5)+ALGBRC(7)+ALGBRC(9))/( CONSTS(35)*CONSTS(36))))
RATES(5) = ALGBRC(11) - ALGBRC(12)
RATES(6) = - ALGBRC(10)+ALGBRC(12)
RATES(7) = CONSTS(33)*(- ALGBRC(10) - ALGBRC(12))
ALGBRC(13) = CONSTS(4)*(EXP(ALGBRC(5)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(1)+ALGBRC(3))/( CONSTS(35)*CONSTS(36))))
RATES(1) = - ALGBRC(11)+ALGBRC(13)
RATES(2) = - ALGBRC(10)+ALGBRC(13)
RATES(4) = ALGBRC(12) - ALGBRC(13)
ALGBRC(14) = CONSTS(35)*CONSTS(36)*log( CONSTS(22)*STATES(9))
ALGBRC(15) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10))
ALGBRC(18) = CONSTS(35)*CONSTS(36)*log( CONSTS(25)*STATES(12))
ALGBRC(21) = CONSTS(5)*(EXP((ALGBRC(14)+ALGBRC(15))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36))))
RATES(9) = - ALGBRC(21)
ALGBRC(16) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8))
ALGBRC(22) = CONSTS(6)*(EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(16)+ALGBRC(15))/( CONSTS(35)*CONSTS(36))))
RATES(12) = ALGBRC(21) - ALGBRC(22)
ALGBRC(17) = CONSTS(35)*CONSTS(36)*log( CONSTS(24)*STATES(11))
ALGBRC(19) = CONSTS(35)*CONSTS(36)*log( CONSTS(26)*STATES(13))
ALGBRC(23) = CONSTS(7)*(EXP((ALGBRC(16)+ALGBRC(17))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(19)/( CONSTS(35)*CONSTS(36))))
ALGBRC(20) = CONSTS(35)*CONSTS(36)*log( CONSTS(27)*STATES(14))
ALGBRC(24) = CONSTS(8)*(EXP((ALGBRC(19)+ALGBRC(16))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(20)+ALGBRC(17))/( CONSTS(35)*CONSTS(36))))
RATES(11) = - ALGBRC(23)+ALGBRC(24)
RATES(13) = ALGBRC(23) - ALGBRC(24)
RATES(14) = ALGBRC(24)
ALGBRC(25) = CONSTS(35)*CONSTS(36)*log( CONSTS(28)*STATES(15))
ALGBRC(26) = CONSTS(35)*CONSTS(36)*log( CONSTS(29)*STATES(16))
ALGBRC(27) = CONSTS(35)*CONSTS(36)*log( CONSTS(30)*STATES(17))
ALGBRC(31) = CONSTS(9)*(EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36))))
ALGBRC(28) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10))
ALGBRC(32) = CONSTS(10)*(EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(28)/( CONSTS(35)*CONSTS(36))))
ALGBRC(33) = CONSTS(11)*(EXP((ALGBRC(27)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(28)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))))
RATES(17) = (ALGBRC(31) - ALGBRC(32)) - ALGBRC(33)
ALGBRC(29) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8))
ALGBRC(34) = CONSTS(12)*(EXP((ALGBRC(28)+ ALGBRC(29)*2.00000)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))))
RATES(8) = (((ALGBRC(10)+ALGBRC(12)+ALGBRC(22)) - ALGBRC(23)) - ALGBRC(24)) - 2.00000*ALGBRC(34)
RATES(10) = (- ALGBRC(21)+ALGBRC(22)+ALGBRC(32)+ALGBRC(33)) - ALGBRC(34)
RATES(15) = - ALGBRC(31)+ALGBRC(34)
ALGBRC(30) = CONSTS(35)*CONSTS(36)*log( CONSTS(31)*STATES(18))
ALGBRC(35) = CONSTS(13)*(EXP(ALGBRC(26)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(30)/( CONSTS(35)*CONSTS(36))))
RATES(16) = ((- ALGBRC(31)+ALGBRC(34)) - ALGBRC(35))+CONSTS(34)
RATES(18) = ALGBRC(35)
RETURN
END
SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC)
REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
ALGBRC(3) = CONSTS(35)*CONSTS(36)*log( CONSTS(15)*STATES(2))
ALGBRC(4) = CONSTS(35)*CONSTS(36)*log( CONSTS(16)*STATES(3))
ALGBRC(7) = CONSTS(35)*CONSTS(36)*log( CONSTS(19)*STATES(6))
ALGBRC(8) = CONSTS(35)*CONSTS(36)*log( CONSTS(20)*STATES(7))
ALGBRC(9) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8))
ALGBRC(10) = CONSTS(1)*(EXP((ALGBRC(3)+ALGBRC(7)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(4)+ALGBRC(9))/( CONSTS(35)*CONSTS(36))))
ALGBRC(1) = CONSTS(35)*CONSTS(36)*log( CONSTS(14)*STATES(1))
ALGBRC(6) = CONSTS(35)*CONSTS(36)*log( CONSTS(18)*STATES(5))
ALGBRC(11) = CONSTS(2)*(EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(6)/( CONSTS(35)*CONSTS(36))))
ALGBRC(5) = CONSTS(35)*CONSTS(36)*log( CONSTS(17)*STATES(4))
ALGBRC(12) = CONSTS(3)*(EXP((ALGBRC(6)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(5)+ALGBRC(7)+ALGBRC(9))/( CONSTS(35)*CONSTS(36))))
ALGBRC(13) = CONSTS(4)*(EXP(ALGBRC(5)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(1)+ALGBRC(3))/( CONSTS(35)*CONSTS(36))))
ALGBRC(14) = CONSTS(35)*CONSTS(36)*log( CONSTS(22)*STATES(9))
ALGBRC(15) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10))
ALGBRC(18) = CONSTS(35)*CONSTS(36)*log( CONSTS(25)*STATES(12))
ALGBRC(21) = CONSTS(5)*(EXP((ALGBRC(14)+ALGBRC(15))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36))))
ALGBRC(16) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8))
ALGBRC(22) = CONSTS(6)*(EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(16)+ALGBRC(15))/( CONSTS(35)*CONSTS(36))))
ALGBRC(17) = CONSTS(35)*CONSTS(36)*log( CONSTS(24)*STATES(11))
ALGBRC(19) = CONSTS(35)*CONSTS(36)*log( CONSTS(26)*STATES(13))
ALGBRC(23) = CONSTS(7)*(EXP((ALGBRC(16)+ALGBRC(17))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(19)/( CONSTS(35)*CONSTS(36))))
ALGBRC(20) = CONSTS(35)*CONSTS(36)*log( CONSTS(27)*STATES(14))
ALGBRC(24) = CONSTS(8)*(EXP((ALGBRC(19)+ALGBRC(16))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(20)+ALGBRC(17))/( CONSTS(35)*CONSTS(36))))
ALGBRC(25) = CONSTS(35)*CONSTS(36)*log( CONSTS(28)*STATES(15))
ALGBRC(26) = CONSTS(35)*CONSTS(36)*log( CONSTS(29)*STATES(16))
ALGBRC(27) = CONSTS(35)*CONSTS(36)*log( CONSTS(30)*STATES(17))
ALGBRC(31) = CONSTS(9)*(EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36))))
ALGBRC(28) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10))
ALGBRC(32) = CONSTS(10)*(EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(28)/( CONSTS(35)*CONSTS(36))))
ALGBRC(33) = CONSTS(11)*(EXP((ALGBRC(27)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(28)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))))
ALGBRC(29) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8))
ALGBRC(34) = CONSTS(12)*(EXP((ALGBRC(28)+ ALGBRC(29)*2.00000)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))))
ALGBRC(30) = CONSTS(35)*CONSTS(36)*log( CONSTS(31)*STATES(18))
ALGBRC(35) = CONSTS(13)*(EXP(ALGBRC(26)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(30)/( CONSTS(35)*CONSTS(36))))
ALGBRC(2) = (STATES(4)+STATES(5))/1.00000
RETURN
END